Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Castillo, Rafael R.; Lozano, Daniel

doi:10.3390/pharmaceutics12050432

Cited by 73 publications

(61 citation statements)

References 201 publications

(230 reference statements)

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“…In this sense, various nanomaterials have been explored in medical research, giving rise to a new area in science, nanomedicine [ 2 , 3 , 4 ]. Among them, nanoparticles (NPs) for drug delivery offer significant advantages in terms of efficacy and safety in comparison with certain conventional therapies [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles Coated with Cell Membranes for Biomedical Applications

Jiménez‐Jiménez

Manzano

Vallet‐Regí

2020

Biology

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Nanoparticles designed for diagnosing and treating different diseases have impacted the scientific research in biomedicine, and are expected to revolutionize the clinic in the near future through a new area called nanomedicine. In the last few years, a new approach in this field has emerged: the use of cell membranes for coating nanoparticles in an attempt to mimic the ability of cells to interface and interact with physiological environments. Although such functions have been replicated through synthetic techniques, many research groups are now employing naturally derived cell membranes to coat different types of nanoparticles in an attempt to improve their performance for a wide range of applications. This review summarizes the literature on nanoparticles coated with cell membranes and, more importantly, aims at inspiring and encouraging new developments to this technology in the biomedical area.

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Section: Introductionmentioning

confidence: 99%

Nanoparticles Coated with Cell Membranes for Biomedical Applications

Jiménez‐Jiménez

Manzano

Vallet‐Regí

2020

Biology

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“…Still considering the biofilm features, there are NPs-based therapeutical approaches that are a powerful weapon against biofilm-associated infection, for instance, the use of the NPs as an antibacterial or even antibiofilm compounds nanocarrier. It is right here where some porous NPs, e.g., MSNPs, become very important armamentous plethora that can be specifically directed against different types of biofilms according to their functionalization and coatings [ 24 , 25 , 215 , 216 , 217 ]. Recently, this type of nanosystems is becoming established as a future treatment for biofilm-related infection [ 182 , 218 ], e.g., bone infections [ 27 , 191 , 195 , 196 ].…”

Section: Nanoparticles and Human Infectionsmentioning

confidence: 99%

Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment

2021

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Infectious diseases hold third place in the top 10 causes of death worldwide and were responsible for more than 6.7 million deaths in 2016. Nanomedicine is a multidisciplinary field which is based on the application of nanotechnology for medical purposes and can be defined as the use of nanomaterials for diagnosis, monitoring, control, prevention, and treatment of diseases, including infectious diseases. One of the most used nanomaterials in nanomedicine are nanoparticles, particles with a nano-scale size that show highly tunable physical and optical properties, and the capacity to a wide library of compounds. This manuscript is intended to be a comprehensive review of the available recent literature on nanoparticles used for the prevention and treatment of human infectious diseases caused by different viruses, and bacteria from a clinical point of view by basing on original articles which talk about what has been made to date and excluding commercial products, but also by highlighting what has not been still made and some clinical concepts that must be considered for futures nanoparticles-based technologies applications.

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“…The poor solubility and large sizes of the therapeutic proteins and their enzymatic and chemical degradation in the gastrointestinal tract commonly compromise their efficacy in cancer therapy. Additionally, the co-delivery of therapeutic proteins along with other therapeutic molecules is a big challenge for the conventional drug delivery systems, as the physicochemical properties of proteins, such as size, surface charge, stability, and susceptibility are very different than the other therapeutic molecules [ 47 ]. Herein, MSN are of special interest for protein delivery due to their possible easily tunable pore sizes, facile surface multi-functionalization, and enormous interior and exterior particle surface [ 48 ].…”

Section: Msns As Delivery Vehicles In Cancer Therapymentioning

confidence: 99%

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Barui

Cauda

2020

Pharmaceutics

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The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

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Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Cited by 73 publications

References 201 publications

Nanoparticles Coated with Cell Membranes for Biomedical Applications

Nanoparticles Coated with Cell Membranes for Biomedical Applications

Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

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