Mesoporous silica nanoparticles as carriers of active agents for smart anticorrosive organic coatings: a critical review

Olivieri, Federico; Castaldo, Rachele; Cocca, Mariacristina; Gentile, Gennaro; Lavorgna, Marino

doi:10.1039/d1nr01899j

Cited by 93 publications

(69 citation statements)

References 188 publications

(425 reference statements)

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“…Silica-based mesoporous nanoparticles (MSNs) have attracted increasing attention as nanocontainers [1][2][3] thanks to their high specific surface area, easy and versatile surface chemistry modification [4], narrow pore size distribution, tunable characteristics of pore network, with pore size ranging from 2 to 50 nm, and excellent biocompatibility with use of triethanolamine (TEA) for synthesizing MSNs with diameter ranging between 20 and 150 nm has been widely reported [27]. It sets reaction mixture pH at 9-10, required for the hydrolysis of alkoxides precursors and growth of porous structures, meanwhile its chelating behavior limits the MSNs growth [27].…”

Section: Introductionmentioning

confidence: 99%

“…Silica-based mesoporous nanoparticles (MSNs) have attracted increasing attention as nanocontainers [ 1 , 2 , 3 ] thanks to their high specific surface area, easy and versatile surface chemistry modification [ 4 ], narrow pore size distribution, tunable characteristics of pore network, with pore size ranging from 2 to 50 nm, and excellent biocompatibility with minimal non-specific or adverse effects [ 5 , 6 ]. These features make these structures potential candidates for delivery of active payloads useful in several fields of application [ 7 ] including catalysis [ 8 ], separation [ 9 ], energy storage [ 10 ], corrosion protection [ 11 ] and in biomedicine [ 12 ], as drug reservoir and bioimaging platforms.…”

Section: Introductionmentioning

confidence: 99%

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High Surface Area Mesoporous Silica Nanoparticles with Tunable Size in the Sub-Micrometer Regime: Insights on the Size and Porosity Control Mechanisms

et al. 2021

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Mesoporous silica nanostructures (MSNs) attract high interest due to their unique and tunable physical chemical features, including high specific surface area and large pore volume, that hold a great potential in a variety of fields, i.e., adsorption, catalysis, and biomedicine. An essential feature for biomedical application of MSNs is limiting MSN size in the sub-micrometer regime to control uptake and cell viability. However, careful size tuning in such a regime remains still challenging. We aim to tackling this issue by developing two synthetic procedures for MSN size modulation, performed in homogenous aqueous/ethanol solution or two-phase aqueous/ethyl acetate system. Both approaches make use of tetraethyl orthosilicate as precursor, in the presence of cetyltrimethylammonium bromide, as structure-directing agent, and NaOH, as base-catalyst. NaOH catalyzed syntheses usually require high temperature (>80 °C) and large reaction medium volume to trigger MSN formation and limit aggregation. Here, a successful modulation of MSNs size from 40 up to 150 nm is demonstrated to be achieved by purposely balancing synthesis conditions, being able, in addition, to keep reaction temperature not higher than 50 °C (30 °C and 50 °C, respectively) and reaction mixture volume low. Through a comprehensive and in-depth systematic morphological and structural investigation, the mechanism and kinetics that sustain the control of MSNs size in such low dimensional regime are defined, highlighting that modulation of size and pores of the structures are mainly mediated by base concentration, reaction time and temperature and ageing, for the homogenous phase approach, and by temperature for the two-phase synthesis. Finally, an in vitro study is performed on bEnd.3 cells to investigate on the cytotoxicity of the MNSs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High Surface Area Mesoporous Silica Nanoparticles with Tunable Size in the Sub-Micrometer Regime: Insights on the Size and Porosity Control Mechanisms

et al. 2021

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“…On the other hand, PMOs demonstrate other distinguishing characteristics such as large and hollow spaces, high surface area, regular cavity wall structure, low density and good membrane permeability, and material loading in large quantities. Therefore, PMOs have been effectively used in many applications such as drug and gene delivery, gas and molecule absorption, sensors, active agents for smart anticorrosive organic coatings, and catalysis 85 , 86 , 89 – 107 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of (E)-2-(1H-tetrazole-5-yl)-3-phenylacrylenenitrile derivatives catalyzed by new ZnO nanoparticles embedded in a thermally stable magnetic periodic mesoporous organosilica under green conditions

Safapoor

Dekamin

Akbari

et al. 2022

Sci Rep

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ZnO nanoparticles embedded in a magnetic isocyanurate-based periodic mesoporous organosilica (Fe3O4@PMO–ICS–ZnO) were prepared through a modified environmentally-benign procedure for the first time and properly characterized by appropriate spectroscopic and analytical methods or techniques used for mesoporous materials. The new thermally stable Fe3O4@PMO–ICS–ZnO nanomaterial with proper active sites and surface area as well as uniform particle size was investigated for the synthesis of medicinally important tetrazole derivatives through cascade condensation and concerted 1,3-cycloaddition reactions as a representative of the Click Chemistry concept. The desired 5-substituted-1H-tetrazole derivatives were smoothly prepared in high to quantitative yields and good purity in EtOH under reflux conditions. Low catalyst loading, short reaction time and the use of green solvents such as EtOH and water instead of carcinogenic DMF as well as easy separation and recyclability of the catalyst for at least five consecutive runs without significant loss of its activity are notable advantages of this new protocol compared to other recent introduced procedures.

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“…Adding to their high surface area, uniform pore sizes and pore volumes, mesoporous silicas also benefit from facile functionalization capabilities. 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

A Comparison of Environmental Impact of Various Silicas Using a Green Chemistry Evaluator

Brambila

Boyd

Keegan

et al. 2022

ACS Sustainable Chem. Eng.

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To answer questions surrounding the sustainability of silica production, MilliporeSigma’s DOZN 2.0 Green Chemistry Evaluator was employed as it provides quantitative values based on the 12 principles of Green Chemistry. As a first study using DOZN 2.0 to evaluate the greenness of nanomaterials, a range of silica types were considered and their greenness scores compared. These included low- and high-value silicas, both commercial and emerging, such as precipitated, gel, fumed, colloidal, mesoporous, and bioinspired silicas. When surveying these different types of silicas, it became clear that while low value silicas have excellent greenness scores, high-value silicas perform poorly on this scale. This highlighted the tension between high-value silicas that are desired for emerging markets and the sustainability of their synthesis. The calculations were able to quantify the issues pertaining to the energy-intensive reactions and subsequent removal of soft templates for the sol–gel processes. The importance of avoiding problematic solvents during processes and particularly releasing them as waste was identified. The calculations were also able to compare the amount of waste generated as well as their hazardous nature. The effects of synthesis conditions on greenness scores were also investigated in order to better understand the relationship between the production process and their sustainability.

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Mesoporous silica nanoparticles as carriers of active agents for smart anticorrosive organic coatings: a critical review

Abstract: Mesoporous silica nanoparticles (MSN) have attracted increasing interest for their applicability as smart nanocarriers of corrosion inhibitors, due to their porous structure, resistance to main corrosive environments and good compatibility...

Cited by 93 publications

References 188 publications

High Surface Area Mesoporous Silica Nanoparticles with Tunable Size in the Sub-Micrometer Regime: Insights on the Size and Porosity Control Mechanisms

High Surface Area Mesoporous Silica Nanoparticles with Tunable Size in the Sub-Micrometer Regime: Insights on the Size and Porosity Control Mechanisms

Synthesis of (E)-2-(1H-tetrazole-5-yl)-3-phenylacrylenenitrile derivatives catalyzed by new ZnO nanoparticles embedded in a thermally stable magnetic periodic mesoporous organosilica under green conditions

A Comparison of Environmental Impact of Various Silicas Using a Green Chemistry Evaluator

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