Mesoporous silica nanoparticles in medicine—Recent advances

Mamaeva, Veronika; Sahlgren, Cecilia; Lindén, Mika

doi:10.1016/j.addr.2012.07.018

Cited by 618 publications

(392 citation statements)

References 115 publications

Supporting

Mentioning

387

Contrasting

Unclassified

Order By: Relevance

“…20 According to DLS and TEM, the particles show a homogeneous size distribution centered around 140 nm which is convenient for their application as drug nanocarriers. 21 In order to provide anchoring points for the protein nanocapsules, the surface of the particles was decorated with carboxylic groups by condensation of 4-(trietoxisililetilene)succidimide with the silanol groups on the surface, followed by hydrolysis in acidic medium. The presence of carboxylic groups was confirmed by the apparition of the characteristic C=O band at 1710 cm -1 in the Fourier-Transform Infrared (FT-IR) spectrum and by Thermogravimetric Analysis (TGA).…”

Section: Resultsmentioning

confidence: 99%

Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues

Villegas

Baeza

Vallet‐Regí

2015

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Poor penetration of drug delivery nanocarriers within dense extracellular matrices constitutes one of the main liabilities of current nanomedicines. The conjugation of proteolytic enzymes on the nanoparticle surface constitutes an attractive alternative. However, the scarce resistance of these enzymes against the action of proteases or other aggressive agents present in the blood stream strongly limits their application. Herein, a novel nanodevice able to transport proteolytic enzymes coated with an engineered pH-responsive polymeric is presented. This degradable coat protects the housed enzymes against proteolytic attack at the same time that it triggers their release under mild acidic conditions, usually present in many tumoral tissues. These enzyme 2 nanocapsules have been attached on the surface of mesoporous silica nanoparticles, as nanocarrier model, showing a significatively higher penetration of the nanoparticles within 3D collagen matrices which housed Human Osteosarcoma cells (HOS). This strategy can improve the therapeutic efficacy of the current nanomedicines allowing a more homogeneous and deeper distribution of the therapeutic nanosystems in cancerous tissues.

show abstract

Section: Resultsmentioning

confidence: 99%

Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues

Villegas

Baeza

Vallet‐Regí

2015

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Mesoporous silica nanoparticles (MSNs) are one of the most representative and explored mesoporous biomaterials in biomedicine due to their high biocompatibility, tunable biodegradation, sustained drug-releasing performance, and easy surface modifications ( Fig. 1) [32][33][34][35]. Compared with traditional MSNs and other carbon-based nanosystems (e.g., carbon nanotubes, graphene, carbon nanodots, and fullerene), mesoporous carbon biomaterials (MCBs), especially mesoporous carbon nanoparticles (MCNs), have been rarely used for biomedical applications, probably due to the lack of adequate synthetic methodologies to fabricate MCNs with desirable composition, dimension, structure, dispersity, and physiochemical properties for biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

View full text Add to dashboard Cite

Nano-biotechnology provides highly efficient and versatile strategies to improve the diagnostic precision and therapeutic efficiency of serious diseases. The development of new biomaterial systems provides great opportunities for the successful clinical translation of nano-biotechnology for personalized biomedicine to benefit patients. As a new inorganic material system, mesoporous carbon biomaterials (

show abstract

“…(Singh et al, 2011). The use of mesoporous silica is one of the more rapidly developing formulation techniques for enhancing the solubility of poorly water-soluble drugs (Vialpando et al, 2011;Mamaeva et al, 2013;Santos et al, 2013;Shen et al, 2013;Xu et al, 2013;Wang et al, 2015). Their large surface area and pore volume make mesoporous silica materials excellent candidates for efficient drug loading and rapid release.…”

Section: Introductionmentioning

confidence: 99%

Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix

et al. 2017

View full text Add to dashboard Cite

In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphatidylethanolamine-poly(ethylene glycol) 2000 (DSPE-PEG) as absorption enhancer and hydroxy propyl methyl cellulose (HPMC) as crystallization inhibitor to prepare sorafenib tosylate (SFN) nanomitrix (MSNM@SFN) for improving the anti-tumor activity of SFN. The MSNM@SFN was prepared by solvent evaporation method. The solubility, dissolution, and bioavailability of SFN in MSNM@SFN were also investigated. The anti-tumor activity of MSNM@SFN was evaluated in vitro and in vivo. Our results indicated that the solubility and dissolution of SFN in MSNM@SFN were significantly increased. The oral bioavailability of SFN in MSNM@SFN was greatly improved 7.7-fold compared with that in SFN suspension. The enhanced anti-tumor activity of MSNM@SFN was confirmed in vitro and in vivo experiments. This nanomatrix developed in this study could be a promising drug delivery platform for improving the therapeutic efficacy of poorly water-soluble drugs.

show abstract

Mesoporous silica nanoparticles in medicine—Recent advances

Cited by 618 publications

References 115 publications

Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues

Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues

Mesoporous carbon biomaterials

Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix

Contact Info

Product

Resources

About