Mesoporous silica nanoparticles in nanotechnology

Douroumis, Dennis; Onyesom, Ichioma; Maniruzzaman, Mohammed; Mitchell, John C.

doi:10.3109/07388551.2012.685860

Cited by 85 publications

(48 citation statements)

References 107 publications

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“…Although an understanding of the interactions between silica nanospheres and phospholipid liposomes is of considerable interest in itself, for example to tune the permeability of the vesicular bilayer, for intra-cellular drug delivery applications [49][50][51] the interactions with cell membranes, rather than lipid-only bilayers, are critical. Several groups have investigated cellular uptake and toxicity of silica particles, using a variety of cell lines and cell culture media.…”

Section: Cell Membrane Interactions Of Silica Nanospheresmentioning

confidence: 99%

“…8,36,[41][42][43][44] In the present study we have employed the liposome leakage assay 24,[45][46][47][48] to probe the interactions with zwitterionic and net anionic vesicular bilayers of amorphous silica nanospheres with a diameter of Z50 nm, the mesoporous analogs of which are under development for targeted drug delivery. [49][50][51] Silica nanospheres of various size and surface chemistry, including biocoating with proteins and lipid bilayers, were investigated. We observed distinct differences in the amount of nanoparticle-induced dye release, at a range of particle/liposome ratios, with a pronounced influence of nanoparticle surface chemistry for the smaller particles and of nanoparticle biocoating for all the particles.…”

Section: Introductionmentioning

confidence: 99%

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Native silica nanoparticles are powerful membrane disruptors

Alkhammash

Berthier

et al. 2015

Phys. Chem. Chem. Phys.

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a Silica nanoparticles are under development for intracellular drug delivery applications but can also have cytotoxic effects including cell membrane damage. In this study, we investigated the interactions of silica nanospheres of different size, surface chemistry and biocoating with membranes of phosphatidylcholine lipids. In liposome leakage assays many, but not all, of these nanoparticles induced dose-dependent dye leakage, indicative of membrane perturbation. It was found that 200 and 500 nm native-silica, aminated and carboxylated nanospheres induce near-total dye release from zwitterionic phosphatidylcholine liposomes at a particle/liposome ratio of B1, regardless of their surface chemistry, which we interpret as particlesupported bilayer formation following a global rearrangement of the vesicular membrane. In contrast, 50 nm diameter native-silica nanospheres did not induce total dye leakage below a particle/liposome ratio of B8, whereas amination or carboxylation, respectively, strongly reduced or prevented dye release. We postulate that for the smaller nanospheres, strong silica-bilayer interactions are manifested as bilayer engulfment of membrane-adsorbed particles, with localized lipid depletion eventually leading to collapse of the vesicular membrane. Protein coating of the particles considerably reduced dye leakage and lipid bilayer coating prevented dye release all together, while the inclusion of 33% anionic lipids in the liposomes reduced dye leakage for both native-silica and aminated surfaces. These results, which are compared with the effect of polystyrene nanoparticles and other engineered nanomaterials on lipid bilayers, and which are discussed in relation to nanosilica-induced cell membrane damage and cytotoxicity, indicate that a native-silica nanoparticle surface chemistry is a particularly strong membrane interaction motif.

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Section: Cell Membrane Interactions Of Silica Nanospheresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Native silica nanoparticles are powerful membrane disruptors

Alkhammash

Berthier

et al. 2015

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

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“…Nanoparticles with larger pores also permit more effective release of the cargo molecule and induce faster degradation of the silica. 28 Since pore size is tunable during MSN synthesis, it is enticing to use currently available pore-swelling techniques to create expanded-pore MSNs (pMSN) for more effective accommodation of the polymer-stabilized ACP. 29 Due to the presence of silanol groups in pMSN, the latter have to be amine-functionalized to create positively-charged surfaces for loading of ACP that are traditionally stabilized …”

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confidence: 99%

Biodegradable mesoporous delivery system for biomineralization precursors

Yang

Niu²,

Sun³

et al. 2017

IJN

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Scaffold supplements such as nanoparticles, components of the extracellular matrix, or growth factors have been incorporated in conventional scaffold materials to produce smart scaffolds for tissue engineering of damaged hard tissues. Due to increasing concerns on the clinical side effects of using large doses of recombinant bone-morphogenetic protein-2 in bone surgery, it is desirable to develop an alternative nanoscale scaffold supplement that is not only osteoinductive, but is also multifunctional in that it can perform other significant bone regenerative roles apart from stimulation of osteogenic differentiation. Because both amorphous calcium phosphate (ACP) and silica are osteoinductive, a biodegradable, nonfunctionalized, expanded-pore mesoporous silica nanoparticle carrier was developed for loading, storage, and sustained release of a novel, biosilicification-inspired, polyamine-stabilized liquid precursor phase of ACP for collagen biomineralization and for release of orthosilicic acid, both of which are conducive to bone growth. Positively charged poly(allylamine)-stabilized ACP (PAH-ACP) could be effectively loaded and released from nonfunctionalized expanded-pore mesoporous silica nanoparticles (pMSN). The PAH-ACP released from loaded pMSN still retained its ability to infiltrate and mineralize collagen fibrils. Complete degradation of pMSN occurred following unloading of their PAH-ACP cargo. Because PAH-ACP loaded pMSN possesses relatively low cytotoxicity to human bone marrow-derived mesenchymal stem cells, these nanoparticles may be blended with any osteoconductive scaffold with macro- and microporosities as a versatile scaffold supplement to enhance bone regeneration.

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“…[25][26][27] Despite their huge potential for biomedical applications, their use as raw material for drug delivery present a major problem, the burst-type uncontrolled release of loaded compounds from the pores when in suspension. 7 This undergoes massive leakages which reduce significantly the cargo efficiency and thus the possible therapeutic effect.…”

Section: Pore Gating By Dna In Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

Castillo¹,

Baeza²

2017

Biomater. Sci.

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The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Much is the importance of those gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits of DNA and RNA. Currently, there could be found in the literature a practically intractable number of examples which report the use in combination of nanoparticles with nucleic acids, which demands boundedness. Following this premise, this revision will only cover the most recent and powerful strategies developed to exploit the possibilities of nucleic acids as biotechnological materials when in combination with mesoporous silica nanoparticles. The extensive research done on nucleic acids has significantly incremented the technological possibilities for those biomacromolecules, which could be employed in many different applications; where substrate or sequence recognition or modulation of biological pathways due to its coding role in living cells are the most promising. In the present revision, the chosen counterpart, mesoporous silica nanoparticles, also with unique properties, became a reference material for drug delivery and biomedical applications due to their high biocompatibility and porous structure suitable for hosting and delivering small molecules. Although most of revisions deal with significant advances in the use of nucleic acid and mesoporous silica nanoparticles in biotechnological applications, a rationale classification of those new generation hybrid materials is still uncovered. Along this review there will be covered promising strategies for living cell and biological sensors, DNA-based molecular gates with targeting, transfection or silencing properties which could provide a significant advance of current nanomedicine.

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Mesoporous silica nanoparticles in nanotechnology

Cited by 85 publications

References 107 publications

Native silica nanoparticles are powerful membrane disruptors

Native silica nanoparticles are powerful membrane disruptors

Biodegradable mesoporous delivery system for biomineralization precursors

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

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