Mesoporous Silica Nanoparticles (MCM-41) Coated PEGylated Chitosan as a pH-Responsive Nanocarrier for Triggered Release of Erythromycin

Pourjavadi, Ali; Tehrani, Zahra Mazaheri

doi:10.1080/00914037.2013.862534

Cited by 57 publications

(37 citation statements)

References 25 publications

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“…MSN have been capped with gatekeepers, including chitosan-PEG copolymers, to regulate payload release, with this controlled by environmental changes at the site of pathology [75,76]. Deng et al [64] have used pH sensitive chitosan in combination with hollow silica nanospheres to deliver protein payloads.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies

Turner

McInnes

Voelcker

et al. 2015

Journal of Nanomaterials

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Monoclonal antibodies (mAbs), available for a range of diseases, including tumours, leukemia, and multiple sclerosis, are emerging as the fastest growing area of therapeutic drug development. The greatest advantage of therapeutic mAbs is their ability to bind with a high degree of specificity to target proteins involved in disease pathophysiology. In response, effector functions are triggered and these ameliorate the disease cascade. As an alternative to this reliance on effector functions, drugs can be conjugated to mAbs. The ability to target compounds to the site of pathology minimises the nonspecific side effects associated with systemic administration. In both instances, optimising the delivery, absorption, and distribution of the mAbs, whilst minimising potential side effects, remain the key hurdles to improved clinical outcomes. Novel delivery strategies are being investigated with more vigour in recent years, and nanoparticles are being identified as suitable vehicles. In conjunction with permitting a controlled release profile, nanoparticles protect the drug from degradation, reducing both the dose and frequency of administration. Moreover, these particles shield the patient from the immune complications associated with high dose mAb infusions or drug cytotoxicity. This review outlines recent advances in nanoparticle technology and how they may be of benefit as therapeutic mAb delivery/targeting vehicles. StructureThe main type of therapeutic mAb is IgG, approximately 150 kDa sized Y-shaped protein structures comprised of two heavy chains linked by disulphide bridges to two light chains (Figure 1(a)). IgG antibodies contain two identical antigen binding sites (Fab), each containing complementarity determining regions (CDRs), which are variable in sequence. IgG antibodies also contain a conserved Fc domain which

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Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies

Turner

McInnes

Voelcker

et al. 2015

Journal of Nanomaterials

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“…Surface modification of the MSNs plays an effective role in improving their biocompatibility. Accordingly, toxicity effect of silanol groups with cellular membranes is able to decrease by coating of MSNs with a polymer shell (Pourjavadi and Tehrani 2014).…”

Section: Introductionmentioning

confidence: 99%

Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment

Nasab

Kumleh

Beygzadeh

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

136

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Mesoporous silica nanocarriers as accommodate drug molecule capsules were synthesized and capped by chitosan natural polymer. This nanocarrier acts as a pH-responsive shield to increase the solubility and improvement of anticancer properties of curcumin against U87MG glioblastoma cancer cell line. The encapsulation efficiency and drug-loading content were measured 88.1 ± 4.76% and 8.81 ± 0.47%, respectively. The curcumin release from the CS-MCM-41 was slow and sustained at low pH (42.72 ± 2.29%) compared to the environment pH (19.54 ± 1.36%) in 96 h. The MTT evaluations showed that IC after 72 h treatment with free curcumin and curcumin-loaded CS-MCM-41 were 15.20 and 5.21 μg/mL (p <0.05). respectively.

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“…As shown in Figure 7, the FTIR spectrums of MSN, MSN/IBU and CS/MSN/IBU show a hydroxyl absorption peak at 1636 cm -1 . And the typical absorption peaks at 1088 and 797 cm -1 were the stretching vibration of Si-O-Si and Si-O [28]. While the adsorption spectrums of IBU, MSN/IBU, CS/MSN/IBU all showed the typical absorption peaks of IBU, which were the stretching vibration of C=O at 1710 cm -1 , C=C vibration and C-H of phenyl ring at 1510 and 1420 cm -1 , respectively.…”

Section: Results and Discussion 31 Morphologies And Structures Of Msnsmentioning

confidence: 99%

“…MSN has been widely used in biomedical due to its good biocompatibility, non-toxic, tunable pore size, large surface areas and pore volume, modifiable surface, biodegradation, good chemical and thermal stabilities and other advantages [19,[23][24][25][26]. But unmodified MSN is not intelligent and has potential toxicity at high dose because of the interactions of surface silanols with cellular membranes [27,28]. So it is necessary to wrap MSN with biomolecules, so that the system is intelligent and low toxicity [28,29].…”

Section: Introductionmentioning

confidence: 99%

“…But unmodified MSN is not intelligent and has potential toxicity at high dose because of the interactions of surface silanols with cellular membranes [27,28]. So it is necessary to wrap MSN with biomolecules, so that the system is intelligent and low toxicity [28,29]. Chitosan has been widely used in intelligent drug delivery system because it has unique properties such as non-toxicity, biocompatibility, biodegradability, and so on [30].…”

Section: Introductionmentioning

confidence: 99%

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Facile and simple preparation of pH-sensitive chitosan-mesoporous silica nanoparticles for future breast cancer treatment

Liu¹,

Yang²,

Shen³

et al. 2015

Express Polym. Lett.

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Abstract. The nanocarrier is linked to the core and shell by hydrogen bond. This drug delivery system represents a smart, biodegradable, and pH-sensitive nanocarrier for breast cancer therapy. These drug nanocarriers were linked by hydrogen bond from -NH 2 on chitosan and -OH on mesoporous silica nanoparticle (MSN). And MSN was prepared by the cetyltrimethyl ammonium bromide (CTAB)-templated method via sol-gel and the loading of ibuprofen (IBU) into the pores of MSN was visualized by coprecipitation which was assessed by Fourier Transform Infrared Spectroscopy (FTIR) and nitrogen adsorption-desorption techniques. The wrapping of chitosan (CS) onto the surface of MSN was demonstrated by FTIR too. When the nanocarriers entered an acidic environment where large quantity cancer cells existed, the chitosan shell swell into loose random coil, exposing the drug and making them easy to be released. The results showed that the IBU could be successfully and effectively loaded into MSN and CS/MSN. The system was pH responsive. Drug release was much higher at pH 6.8 than at 7.4. This drug delivery system will represent a smart and biodegradable pH-responsive nanocarrier for breast cancer.

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Mesoporous Silica Nanoparticles (MCM-41) Coated PEGylated Chitosan as a pH-Responsive Nanocarrier for Triggered Release of Erythromycin

Cited by 57 publications

References 25 publications

Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies

Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies

Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment

Facile and simple preparation of pH-sensitive chitosan-mesoporous silica nanoparticles for future breast cancer treatment

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