Mesoporous silica nanoparticles with chiral pattern topological structure function as “antiskid tires” on the intestinal mucosa to facilitate oral drugs delivery

Wei, Xin; Wang, Lin; Lin, Jai-Ming; Wang, Yanbu; Pan, Qi; Yang, Han Na; Bao, Zhiye; Zong, Shun; Cheng, Ying; Chen, Xuchun; Zhao, Lin; Li, Heran

doi:10.1016/j.ajps.2023.100795

Asian Journal of Pharmaceutical Sciences

2023

DOI: 10.1016/j.ajps.2023.100795

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Mesoporous silica nanoparticles with chiral pattern topological structure function as “antiskid tires” on the intestinal mucosa to facilitate oral drugs delivery

Xin Wei

Lin Wang

Jai-Ming Lin

et al.

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Cited by 4 publications

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Enantioselective Oral Absorption of Molecular Chiral Mesoporous Silica Nanoparticles

Wang,

Zhao,

Dai

et al. 2023

Advanced Materials

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Inspired by the unique pharmacological effects of chiral drugs in the asymmetrical body environments, we assumed the chirality of nanocarriers was also a key factor to determine their oral adsorption efficiency, apart from their size, shape, etc. Herein, we fabricated L/D‐tartaric acid modified mesoporous silica nanoparticles (L/D‐CMSNs) via a one‐pot co‐condensation method, and focused on whether the oral adsorption of nanocarriers would be benefited from their chirality. We found that L‐CMSN performed better in the sequential oral absorption processes, including mucus permeation, mucosa bio‐adhesion, cellular uptake, intestinal transport and gastrointestinal tract (GIT) retention, than those of the D‐chiral (D‐CMSN), racemic (DL‐CMSN), and achiral (MSN) counterparts. We experimentally and theoretically demonstrated the multiple chiral recognition mechanisms following simple differential adsorption on bio‐interfaces, wherein electrostatic interaction was the dominant energy. During the oral delivery task, L‐CMSN, which was proven to be stable, nonirritative, biocompatible and biodegradable, was efficiently absorbed into the blood (1.72–2.05‐fold higher than other nanocarriers), and helped the loaded doxorubicin (DOX) to achieve better intestinal transport (2.32–27.03‐times higher than other samples), satisfactory bioavailability (449.73%) and stronger anti‐tumor effect (up to 95.43%). These findings validated the dominant role of chirality in determining the biological fate of nanocarriers.This article is protected by copyright. All rights reserved

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Enantioselective Oral Absorption of Molecular Chiral Mesoporous Silica Nanoparticles

Wang,

Zhao,

Dai

et al. 2023

Advanced Materials

Self Cite

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Insights into drug loading techniques with mesoporous silica nanoparticles: Optimization of operating conditions and assessment of drug stability

Khalbas,

Albayati,

Saady

et al. 2024

Journal of Drug Delivery Science and Technology

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Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion

Rahman,

Singh,

Aodah

et al. 2024

Expert Opinion on Drug Delivery

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Mesoporous silica nanoparticles with chiral pattern topological structure function as “antiskid tires” on the intestinal mucosa to facilitate oral drugs delivery

Cited by 4 publications

References 33 publications

Enantioselective Oral Absorption of Molecular Chiral Mesoporous Silica Nanoparticles

Enantioselective Oral Absorption of Molecular Chiral Mesoporous Silica Nanoparticles

Insights into drug loading techniques with mesoporous silica nanoparticles: Optimization of operating conditions and assessment of drug stability

Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion

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