Mesoporous silica/organosilica nanoparticles for cancer immunotherapy

Abstract

Cancer is one of the fatal diseases in the history of humankind. In this regard, cancer immunotherapeutic strategies have revolutionized the traditional mode of cancer treatment. Silica based nano-platforms have been extensively applied in nanomedicine including cancer immunotherapy. Mesoporous silica nanoparticles (MSN) and mesoporous organosilica nanoparticles (MON) are attractive candidates due to the ease in controlling the structural parameters as needed for the targeted immunotherapeutic applications. Especially, the MON provide an additional advantage of controlling the composition and modulating the biological functions to actively synergize with other immunotherapeutic strategies. In this review, the applications of MSN, MON, and metal-doped MSN/MON in the field of cancer immunotherapy and tumor microenvironment regulation are comprehensively summarized by highlighting the structural and compositional attributes of the silica-based nanoplatforms.

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

“…The employment of porous silicon and MSNs/MONs as vehicles and immunotherapy nanoplatforms has been comprehensively summarized in several previous reviews. 188,596,597 Here, we will emphasize the intrinsic immunogenicity of silicon-composed biomaterials.…”

Recent progress in lactate oxidase-based drug delivery systems for enhanced cancer therapy

“…They are widely used in drug delivery and biomedical fields due to their simple synthesis process, large surface area, and controllable structural parameters. [58][59][60] Tan et al fabricated HMON-LOD by attaching LOX to the shell surface of hollow mesoporous organosilicon nanoparticles (HMONs). HMON-LOD is safer than free LOX, which resulted in the death of mice when administered intravenously.…”

Oral Nanomedicine: Challenges and Opportunities

“…Among various inorganic nanoparticles, silica nanoparticles have merits such as high surface modifiability, good biocompatibility, enzyme stability, and low cost. [66,67] In recent years, oral applications based on silica nanoparticles have been gradually increasing.…”