Mesoporous titania-ceria mixed oxide (MTCMO) catalyzed one-pot green synthesis and antibacterial activity of diethyl (((4-(N-(5-methyl-4, 5- dihydroisoxazol-3-yl)sulfamoyl)phenyl)amino)(substituted methyl) phosphonates

Abstract

An efficient green synthesis of diethyl (((4-(N-(5-methyl-4,5-dihydroisoxazol-3-yl)sulfamoyl)phenyl)amino)(substituted methyl) phosphonates was accomplished by the condensation of 4-amino-N-(5-methyl-4,5-dihydroisoxazol-3yl)benzenesulfonamide with various aldehydes and diethyl phosphite using mesoporous titania-ceria mixed oxide (MTCMO) as a nano-catalyst under microwave irradiation and solvent free conditions. Antimicrobial activity was performed for the synthesized compounds and the compounds 4a, 4c, 4d, 4e and 4f exhibited highest inhibitory activity against Escherichia coli and Bacillus subtilis using Penicillin and Tetracycline as standards.