Mesothelial Cell Proliferation and Biopersistence of Wollastonite and Crocidolite Asbestos Fibers

Macdonald, J. L.; Kane, Agnes B.

doi:10.1093/toxsci/38.2.173

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…Wollastonite exposure does not induce lung disease due to its rapid dissolution and lack of surface reactivity. 46–48 In contrast, both in vitro and in vivo studies show that crocidolite asbestos fibers dissolve slowly, with a half-life of 240 days, while longer (>5um) fibers persist for over one year in rats. 49,50 Long crocidolite asbestos fibers undergo frustrated phagocytosis and the retention of these fibers in the lungs and pleura results in extensive cytotoxicity due to the surface redox activity of iron (III) along the fiber surfaces leading to the formation of reactive oxygen species.…”

Section: Introductionmentioning

confidence: 99%

Biodissolution and cellular response to MoO₃nanoribbons and a new framework for early hazard screening for 2D materials

Gray

Browning

Wang

et al. 2018

Environ. Sci.: Nano

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Two-dimensional (2D) materials are a broad class of synthetic ultra-thin sheet-like solids whose rapid pace of development motivates systematic study of their biological effects and safe design. A challenge for this effort is the large number of new materials and their chemical diversity. Recent work suggests that many 2D materials will be thermodynamically unstable and thus non-persistent in biological environments. Such information could inform and accelerate safety assessment, but experimental data to confirm the thermodynamic predictions is lacking. Here we propose a framework for early hazard screening of nanosheet materials based on biodissolution studies in reactive media, specially chosen for each material to match chemically feasible degradation pathways. Simple dissolution and in vitro tests allow grouping of nanosheet materials into four classes: A, potentially biopersistent; B: slowly degradable (>24–48 hours); C, biosoluble with potentially hazardous degradation products; and D, biosoluble with low-hazard degradation products. The proposed framework is demonstrated through an experimental case study on MoO3 nanoribbons, which have a dual 2D / 1D morphology and have been reported to be stable in aqueous stock solutions. The nanoribbons are shown to undergo rapid dissolution in biological simulant fluids and in cell culture, where they elicit no adverse responses up to 100μg ml−1 dose. These results place MoO3 nanoribbons in Class D, and assigns them a low priority for further nanotoxicology testing. We anticipate use of this framework could accelerate the risk assessment for the large set of new powdered 2D nanosheet materials, and promote their safe design and commercialization.

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Section: Introductionmentioning

confidence: 99%

Biodissolution and cellular response to MoO₃nanoribbons and a new framework for early hazard screening for 2D materials

Gray

Browning

Wang

et al. 2018

Environ. Sci.: Nano

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“…7 Mesothelial cell proliferation is associated with fiber biopersistence, as crocidolite asbestos induces a more extended proliferative response than wollastonite, which is susceptible to dissolution and clearance in vivo. 150 Biopersistent asbestos fibers may induce chronic cellular proliferation directly through upregulated expression of growth factors and activation of growth factor receptors. Asbestos fibers have been shown to bind and activate the epidermal growth factor receptor, and downstream mitogen-activated protein kinases (MAPKs): ERK1 and ERK2.…”

Section: Stimulation Of Target Cell Proliferationmentioning

confidence: 99%

Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?

Sanchez

Pietruska

Miselis

et al. 2009

WIREs Nanomed Nanobiotechnol

170

148

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Human diseases associated with exposure to asbestos fibers include pleural fibrosis and plaques, pulmonary fibrosis (asbestosis), lung cancer, and diffuse malignant mesothelioma. The critical determinants of fiber bioactivity and toxicity include not only fiber dimensions, but also shape, surface reactivity, crystallinity, chemical composition, and presence of transition metals. Depending on their size and dimensions, inhaled fibers can penetrate the respiratory tract to the distal airways and into the alveolar spaces. Fibers can be cleared by several mechanisms, including the mucociliary escalator, engulfment, and removal by macrophages, or through splitting and chemical modification. Biopersistence of long asbestos fibers can lead to inflammation, granuloma formation, fibrosis, and cancer. Exposure to synthetic carbon nanomaterials, including carbon nanofibers and carbon nanotubes (CNTs), is considered a potential health hazard because of their physical similarities with asbestos fibers. Respiratory exposure to CNTs can produce an inflammatory response, diffuse interstitial fibrosis, and formation of fibrotic granulomas similar to that observed in asbestos-exposed animals and humans. Given the known cytotoxic and carcinogenic properties of asbestos fibers, toxicity of fibrous nanomaterials is a topic of intense study. The mechanisms of nanomaterial toxicity remain to be fully elucidated, but recent evidence suggests points of similarity with asbestos fibers, including a role for generation of reactive oxygen species, oxidative stress, and genotoxicity. Considering the rapid increase in production and use of fibrous nanomaterials, it is imperative to gain a thorough understanding of their biologic activity to avoid the human health catastrophe that has resulted from widespread use of asbestos fibers.The manufacturing of engineered nanomaterials for both consumer and industrial applications is undergoing exponential growth. Among the many nanomaterials produced since the discovery of fullerenes in 1985, 1 carbon nanofibers (CNFs) and carbon nanotubes (CNTs) are exceptionally attractive, because of their high strength-to-weight ratio, high surface area, thermal stability, and resistance to chemicals. 2 Their unique physicochemical characteristics are expected to be useful in a wide range of applications, including reinforcement of biomaterials, optical devices, drug delivery, biosensors, as well as conducting and reinforcing fillers in polymer composites.Inhalation exposure in occupational environments can occur during the synthesis, collection, purification, handling, and packing of nanomaterials. Because of their shape and dimensions, in particular their high aspect ratio, graphenic CNTs may have similar pathogenic potential as naturally occurring asbestiform fibers. Their structural resemblance to asbestos fibers 3 and potential biopersistence make fibrous carbon nanomaterials a potential human health hazard. *Correspondence to: agnes kane@brown.edu. NIH Public Access Author ManuscriptWiley Interdiscip...

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Section: Other Studiesmentioning

confidence: 99%

“…For example, Macdonald and Kane (1997) compared the mesothelial cell proliferation induced by wollastonite (NYAD 1250, NYCO Minerals) and UICC crocidolite. Macdonald and Kane (1997) included crocidolite in the study because it is both biopersistent and carcinogenic. Wollastonite was included because of its low biopersistence and the negative bioassay results of Pott et al (1987) and McConnell et al (1991).…”

Section: Other Studiesmentioning

confidence: 99%

A Review of the Toxicology and Epidemiology of Wollastonite

Maxim¹,

McConnell

2005

Inhalation Toxicology

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Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying degrees, wollastonite grades contain respirable particles/fibers, some of which have lengths and diameters that might be biologically active if deposited and retained in the lung. In this review we provide background information on wollastonite properties, markets, production and use, regulatory classification, and occupational exposure limits. We also summarize the available studies on the toxicology and epidemiology of wollastonite. We conclude that there is inadequate evidence for the carcinogenicity of wollastonite in animals and, based on strong evidence that wollastonite is not biopersistent, believe that a well-designed animal inhalation bioassay would have a negative result. The epidemiological evidence for wollastonite is limited, but does not suggest that workers are at significant risk of an increased incidence of pulmonary fibrosis, lung cancer, or mesothelioma. Morbidity studies have demonstrated a nonspecific increase in bronchitis and reduced lung function. It is prudent, however, to continue product stewardship efforts by wollastonite producers to control workplace exposures and to monitor scientific developments.

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Mesothelial Cell Proliferation and Biopersistence of Wollastonite and Crocidolite Asbestos Fibers

Cited by 5 publications

References 17 publications

Biodissolution and cellular response to MoO₃nanoribbons and a new framework for early hazard screening for 2D materials

Biodissolution and cellular response to MoO₃nanoribbons and a new framework for early hazard screening for 2D materials

Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?

A Review of the Toxicology and Epidemiology of Wollastonite

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Mesothelial Cell Proliferation and Biopersistence of Wollastonite and Crocidolite Asbestos Fibers

Cited by 5 publications

References 17 publications

Biodissolution and cellular response to MoO3nanoribbons and a new framework for early hazard screening for 2D materials

Biodissolution and cellular response to MoO3nanoribbons and a new framework for early hazard screening for 2D materials

Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?

A Review of the Toxicology and Epidemiology of Wollastonite

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Product

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Biodissolution and cellular response to MoO₃nanoribbons and a new framework for early hazard screening for 2D materials

Biodissolution and cellular response to MoO₃nanoribbons and a new framework for early hazard screening for 2D materials