Mesothelin-related predictive and prognostic factors in malignant mesothelioma: A nested case–control study

Røe, Oluf Dimitri; Creaney, Jenette; Lundgren, Steinar; Larsson, Erik G.; Sandeck, Helmut; Boffetta, Paolo; Nilsen, Tom Ivar Lund; Robinson, Bruce; Kjærheim, Kristina

doi:10.1016/j.lungcan.2007.12.025

Cited by 52 publications

(54 citation statements)

References 62 publications

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“…The SMRP cut-off was 2.3 nmol/L. The authors observed neither elevated serum SMRP levels prior to the diagnosis of pleural mesothelioma nor differences in SMRP concentration between the mesothelioma group and controls 36 . Conversely, this study showed significantly higher mesothelin levels in persons with pathological findings as compared with healthy individuals (0.78 ± 0.63 vs. 0.50 ± 0.35, P<0.0001).…”

Section: Discussionmentioning

confidence: 75%

“…Given the small number of pleural mesothelioma cases, mesothelin levels could not be compared between pleural mesothelioma and other malignancies. Some studies claim that there is no increase in SMRP at 12 months or more before the diagnosis of mesothelioma 8,36 . On the other hand, it is suggested that at least six months prior to the development of clinical manifestations of mesothelioma, SMRP levels are significantly increased 49 .…”

Section: Discussionmentioning

confidence: 99%

“…It performs numerous physiological functions in the organism 34 . It is overexpressed in many cancers; most frequently in mesothelioma, less frequently in ovarian, pancreatic and lung cancers (especially adenocarcinoma) and rarely in breast, colon, endometrial and kidney cancers and sarcoma [35][36][37][38][39][40] . In pleural biopsies, the immunohistochemical positivity of mesothelin has a sensitivity of 75-100% and specificity of 90% for pleural mesothelioma 38,41 .…”

Section: Introductionmentioning

confidence: 99%

“…Increased SMRP levels are common in mesothelioma, especially epithelioid, less frequent in pancreatic, ovarian and lung cancers, and rare in other malignancies. SMRP may be mildly to moderately increased in benign cases such as those with asbestos exposure, arterial hypertension, congestive heart failure or renal insufficiency 36 . Serum SMRP levels may be affected by age, weight (body mass index < 25), high glucose levels, smoking and a history of malignancy or asbestos-related pleural involvement [49][50][51][52] .…”

Section: Introductionmentioning

confidence: 99%

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Significance of serum mesothelin in an asbestos-exposed population in the Czech Republic

Jakubec¹,

Pelclová²,

Smolková³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. Pleural mesothelioma is a highly aggressive and difficult-to-treat form of cancer induced by asbestos in 80-90% of cases. The population group most at risk of the condition are asbestos-exposed workers. Mesothelin or soluble mesothelin-related protein (SMRP) is studied as a potential marker of mesothelioma in the at-risk population. Methods. The study comprised 239 subjects with a mean duration of occupational exposure to asbestos of 19.9 years. In all of them, a complete medical history was taken, focused on exposure duration and a physical examination, a chest X-ray or other imaging investigations and a lung function test were performed. Their serum SMRP levels were measured and biopsy samples were taken to diagnose pleural disease. Based on the above examinations, the subjects were classified into subgroups and serum SMRP concentrations were statistically analyzed with respect to individual parameters. Results. In asbestos-exposed individuals, mesothelin levels were significantly higher in those with pathological X-ray findings than in those with normal X-ray results (0.78 ± 0.63 vs. 0.50 ± 0.35, P<0.0001). The group of patients with benign disease had statistically significantly higher mesothelin levels than those with normal X-ray findings (0.755 ± 0.543 vs. 0.50 ± 0.35, P<0.001). In the group with present malignant processes, mesothelin levels were higher than in individuals with benign disease (1.19 ± 0.89 vs. 0.76 ± 0.54, P=0.015). Only a weak correlation was found between mesothelin levels and asbestos exposure duration. There were relatively high sensitivity and high specificity (75% and 90.6%, respectively) of serum mesothelin for pleural mesothelioma. However, given the small number of mesothelioma cases in the group, the results cannot be considered as statistically significant. Conclusions. In persons followed up for asbestos exposure, increased mesothelin levels signalize pathological processes in the chest and correlate with severity of the disease. The study suggests that mesothelin cannot be considered a reliable marker for the early stage of malignant degeneration of pleural disease but only an additional criterion for examination of the followed-up individuals.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Significance of serum mesothelin in an asbestos-exposed population in the Czech Republic

Jakubec¹,

Pelclová²,

Smolková³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Data from literature shows that in asbestos exposed subjects serum mesothelin is only marginally but not significantly increased over normal unexposed subjects [71] and there seems to be no increase over time [79]. Roe et al showed in a small series of 47 malignant mesothelioma for which they had available at least one serum sample, sampled between 6 months and 30 years before diagnosis that there is no significant elevation of serum mesothelin which could be useful for early mesothelioma diagnosis [80]. In this series neither CYFRA 21.1 nor CA 125 were more useful for mesothelioma early diagnosis.…”

Section: Mesothelinmentioning

confidence: 99%

Clinical utility of diagnostic markers for malignant pleural mesothelioma

Grigoriu

Grigoriu²,

Chahine

et al. 2016

Monaldi Arch Chest Dis

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Malignant mesothelioma has a very dismal prognosis with very few patients surviving one year after diagnosis. Early multimodal treatment, however, is expected to improve the outcome. Today, there is a strong need to have disease markers which could be used for screening, diagnosing, and/or monitoring tumour response to treatment. Old markers such as hyaluronic acid, various cytokeratin fragments (CYFRA 21.1, TPA) and other cancer antigens (CA 15.3, CA 125 or CA 19.9 or CEA) are not sensitive or specific enough and cannot be used in practice. More recently new molecules, such as soluble mesothelin and osteopontin, have been proposed for diagnostic purposes. Soluble mesothelin has a good specificity but has a suboptimal sensitivity being negative in all sarcomatoid and in up to one half of epithelioid mesothelioma. On the contrary osteopontin has an inadequate specificity. Combining different markers together does not lead to an improvement in diagnostic accuracy. Neither marker can be used for screening purposes, the main limitation being the very low incidence of the disease in the at-risk, asbestos exposed population. Mesothelin is also a promising marker for monitoring response to treatment but published data is still insufficient to make recommendations. There is still a strong need for research is this area both in order to discover new markers as well as to correct the positioning of each existing molecule (alone or in combination) is the evaluation of the patients with a mesothelioma.

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Mesothelin expression correlates with prolonged patient survival in gastric cancer

Baba

Ishigami

Arigami

et al. 2011

Journal of Surgical Oncology

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Mesothelin-related predictive and prognostic factors in malignant mesothelioma: A nested case–control study

Cited by 52 publications

References 62 publications

Significance of serum mesothelin in an asbestos-exposed population in the Czech Republic

Significance of serum mesothelin in an asbestos-exposed population in the Czech Republic

Clinical utility of diagnostic markers for malignant pleural mesothelioma

Mesothelin expression correlates with prolonged patient survival in gastric cancer

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