Mesothelioma: A Study of 22 Case

King, Judy; Tucker, John; Wong, Su-Yong

doi:10.1097/00007611-199702000-00006

Cited by 24 publications

(10 citation statements)

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“…Recent reports have shown that a large percentage (50 -70%) of patients develop distant metastases during their clinical course. 13,14 We have also observed this trend in our series of cases, in which a number of cases of mesothelioma aspirated (7 of 13 cases) were of distant metastases; in the past 2 yr, an even greater percentage of cases (7 of 11) represented distant spread.…”

Section: Discussionsupporting

confidence: 74%

Changing clinical course of patients with malignant mesothelioma: Implications for FNA cytology and utility of immunocytochemical staining

Soma

Hahn

et al. 2001

Diagnostic Cytopathology

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The diagnosis of both local recurrences and distant metastases of mesothelioma can be accomplished by fine-needle aspiration (FNA) biopsy. Although the previous history of mesothelioma provides strong support for recurrent/metastatic mesothelioma, other diagnostic possibilities (particularly adenocarcinoma) may require exclusion via special stains in some cases. In this study, we report on the morphologic findings in 13 cases of mesothelioma which underwent FNA (7 metastatic lesions, 6 local recurrences). In addition, immunohistochemical staining results for 7 cases with available material using antibodies directed against cytokeratin AE 1/3 and two antibodies reported to show consistently positive results in mesothelioma (calretinin and cytokeratin 5/6) are reported and compared to results seen for 10 cases of adenocarcinoma. All cases of mesothelioma and adenocarcinoma showed strong staining with cytokeratin AE 1/3. Three of 7 cases of mesothelioma showed strong staining with calretinin, while only focal staining was detected in 3 additional cases; only one case showed positive staining with cytokeratin 5/6. One of 10 cases of adenocarcinoma showed calretinin positivity; however, at least focal staining with cytokeratin 5/6 was seen in 4 cases. These results suggest that cytokeratin 5/6 is neither a sensitive nor specific stain for the diagnosis of mesothelioma in cytology material. Calretinin appears to be more specific for mesothelioma but showed disappointing sensitivity for this tumor, potentially limiting its diagnostic utility in FNA material.

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Section: Discussionsupporting

confidence: 74%

Changing clinical course of patients with malignant mesothelioma: Implications for FNA cytology and utility of immunocytochemical staining

Soma

Hahn

et al. 2001

Diagnostic Cytopathology

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“…Immunostaining with monoclonal antibody for Ber-EP4 was reported to have a positive predictive value for distinguishing adenocarcinoma from MPM of 96% and a negative predictive value of 70% [Maguir et al, 1994;King et al, 1997].…”

Section: Discussionmentioning

confidence: 99%

Malignant pleural mesothelioma presenting as spontaneous pneumothorax: a case series and review

et al. 2000

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Background Malignant pleural mesothelioma (MPM) is thought to arise from the mesothelial cells that line the pleural cavities. Most patients initially experience the insidious onset of chest pain or shortness of breath, and it rarely presents as spontaneous pneumothorax. Case reports We report four patients who presented in this manner. Three of the patients were exposed to asbestos directly or indirectly at shipyards during World War II; the fourth was exposed as an insulator's wife. Two of our cases were not recognized to have MPM on histologic examination at first thoracotomy and remained asymptomatic for 12 and 22 months, respectively. In none of the patients described herein, was spontaneous pneumothorax the cause of death. Conclusions Since many people were exposed to asbestos during and after World War II, spontaneous pneumothorax in a patient with the possibility of such exposure should raise the suspicion of malignant pleural mesothelioma. Am. J. Ind. Med. 38:219–223, 2000. © 2000 Wiley‐Liss, Inc.

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“…To differentiate mesothelioma from adenocarcinoma and to establish the diagnosis, three techniques have been employed: Histochemical staining with periodic acid-Schiff, immunostaining, and electron microscopy to establish the ultrastructural features of mesothelioma, including the absence of microvillus core rootlets, glycocalyceal bodies and secretory granules, the presence of intracellular desmosomes, junctional complexes, and intracytoplasmic lumina, and characteristically long and thin microvilli [Cibas et al, 1987]. Immunostaining with monoclonal antibody for Ber-EP4 was reported to have a positive predictive value for distinguishing adenocarcinoma from MPM of 96% and a negative predictive value of 70% [Maguir et al, 1994;King et al, 1997].…”

Section: Discussionmentioning

confidence: 99%

Malignant pleural mesothelioma presenting as spontaneous pneumothorax: a case series and review

Alkhuja,

Miller,

Mastellone

et al. 2000

Am. J. Ind. Med.

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Background Malignant pleural mesothelioma (MPM) is thought to arise from the mesothelial cells that line the pleural cavities. Most patients initially experience the insidious onset of chest pain or shortness of breath, and it rarely presents as spontaneous pneumothorax. Case reports We report four patients who presented in this manner. Three of the patients were exposed to asbestos directly or indirectly at shipyards during World War II; the fourth was exposed as an insulator's wife. Two of our cases were not recognized to have MPM on histologic examination at ®rst thoracotomy and remained asymptomatic for 12 and 22 months, respectively. In none of the patients described herein, was spontaneous pneumothorax the cause of death. Conclusion Since many people were exposed to asbestos during and after World War II, spontaneous pneumothorax in a patient with the possibility of such exposure should raise the suspicion of malignant pleural mesothelioma.

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Mesothelioma: A Study of 22 Case

Cited by 24 publications

References 0 publications

Changing clinical course of patients with malignant mesothelioma: Implications for FNA cytology and utility of immunocytochemical staining

Changing clinical course of patients with malignant mesothelioma: Implications for FNA cytology and utility of immunocytochemical staining

Malignant pleural mesothelioma presenting as spontaneous pneumothorax: a case series and review

Malignant pleural mesothelioma presenting as spontaneous pneumothorax: a case series and review

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