Mesothelioma and Asbestos-Related Pleural Diseases

Greillier, L.; Astoul, Philippe

doi:10.1159/000127577

Cited by 57 publications

(37 citation statements)

References 293 publications

(200 reference statements)

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“…Many issues remain to be resolved, such as delineating the complications of SSc in SILs (3), or those complications associated with malignant tumors such as mesothelioma and lung cancer in patients exposed to the mineral silicate asbestos (27). Regarding the relationship between tumor immunity and Treg function, it may be that Treg enhances cell numbers or function to reduce tumor immunity (28).…”

Section: Discussionmentioning

confidence: 99%

Reductive Alteration of the Regulatory Function of the CD4+CD25+ T Cell Fraction in Silicosis Patients

Hayashi

Miura

Maeda

et al. 2010

Int J Immunopathol Pharmacol

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Causal links have been documented between silica and rheumatoid arthritis, lupus erythematosus, systemic sclerosis and glomerulonephritis. Two different effects of silica have been suggested, an enhanced inflammatory response in the pulmonary region (e.g. activation of alveolar macrophages) and dysregulation of autoimmunity. Based on our previous reports showing in vitro activation of peripheral T cells by silica and reduced regulatory function of the peripheral CD4+CD25+ fraction in which FoxP3+ regulatory T cells (Treg) are located, reconstitution of the CD4+CD25+ fraction in silicosis patients (SILs) was investigated. Since T cells in peripheral CD4+CD25+ and CD4+CD25− (effector T cells; Teff) fractions from SILs showed higher expression of pd-1 (a marker gene for T cell activation) in comparison to that of healthy donors (HDs), chronic T cell activation was considered to have occurred in SILs. In this study, a higher expression of the CD95/Fas molecule in Treg was recorded from silicosis patients (SILs) compared to healthy donors (HDs), and excess loss of FoxP3+ Treg in freshly isolated peripheral blood mononuclear cells (PBMCs) from SILs relative to HDs was demonstrated when these cells were cultured with silica ex vivo, whereas CD25+ cells were not reduced due to contamination of activated Teff in the CD4+CD25+ fraction. The activation of both Teff and Treg results in reconstitution of the peripheral CD4+ CD25+ fraction, loss of Treg and contamination of activated Teff, resulting in reduction of the number and function of Treg. These results contribute to our understanding of the development of autoimmune diseases found in SILs.

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Section: Discussionmentioning

confidence: 99%

Reductive Alteration of the Regulatory Function of the CD4+CD25+ T Cell Fraction in Silicosis Patients

Hayashi

Miura

Maeda

et al. 2010

Int J Immunopathol Pharmacol

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“…The strong relationship between asbestos exposure and MPM has been recognized in the early 1960s [1,2]. It is generally caused by environmental and occupational asbestos exposure.…”

Section: Introductionmentioning

confidence: 99%

A Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesothelioma

Tanrıkulu

Abakay

Kaplan³

et al. 2010

Respiration

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Background: Malignant pleural mesothelioma (MPM) has a poor prognosis. Objectives: Only few studies in literature investigated the presence of pleural fluid and radiographic findings for the prognosis of MPM. Methods: We retrospectively investigated the hospital charts of 363 MPM patients who were diagnosed from January 1989 to March 2010. Survival time was calculated by the Kaplan-Meier method. Pretreatment clinical, laboratory and radiographic features of each patient at the time of diagnosis were obtained from patients’ charts. Results: The mean age of 363 patients (217 men, 146 women) was 50.6 ± 11.2 years (range 19–85) and the mean survival time was 11.7 ± 8.6 months (range 1–53). Histological types of MPM were epithelial (71.2%), mixed (15.9%) and sarcomatous type (4.9%). The frequency of disease stages were 31.4% for stage 1, 24.2% for stage 2, 28.6% for stage 3 and 15.8% for stage 4. The most frequent symptoms were dyspnea (82.1%), chest pain (68.3%) and weight loss (58.9%). Results of univariate and multivariate analyses revealed that a Karnofsky performance score ≤60, a pleural fluid glucose level ≤40 mg/dl, a C-reactive protein level >50 mg/l, a serum lactate dehydrogenase level >500 U/l, the presence of pleural fluid, pleural thickening >1 cm and a platelet count of >420 × 10³/µl were found to be associated with poor prognosis in MPM. Conclusions: Our data suggest that low pleural fluid glucose and high C-reactive protein, the presence of pleural fluid and pleural thickening were associated with poor MPM prognosis. Further prospective studies are needed to highlight prognostic factors more clearly.

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“…1 Although there has been some progress in the treatment of these cancers, the overall prognosis remains very poor. Bcl-xl is a key antiapoptotic protein expressed in many tumor types and its overexpression is believed to contribute to chemotherapeutic resistance in mesotheliomas.…”

mentioning

confidence: 99%

Up-Regulation of Bcl-xl by Hepatocyte Growth Factor in Human Mesothelioma Cells Involves ETS Transcription Factors

Cao

Littlejohn

Rodarte

et al. 2009

The American Journal of Pathology

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Mesothelioma and Asbestos-Related Pleural Diseases

Cited by 57 publications

References 293 publications

Reductive Alteration of the Regulatory Function of the CD4+CD25+ T Cell Fraction in Silicosis Patients

Reductive Alteration of the Regulatory Function of the CD4+CD25+ T Cell Fraction in Silicosis Patients

A Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesothelioma

Up-Regulation of Bcl-xl by Hepatocyte Growth Factor in Human Mesothelioma Cells Involves ETS Transcription Factors

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