Mesothelioma from Chrysotile Asbestos: Update

Asbestos-Related Research: First Objectivity then Conclusions

“…Other reports and reviews [43][44][45][46][47][48]51,56,58,63,[72][73][74][75], not supporting the authors' concept, are also not cited in the voluminous reviews [41,55]. Another example: Bernstein et al cite a rather nondescript phrase from the review "Mesothelioma from chrysotile asbestos" [55,76] that chrysotile is an "exclusive or overwhelming fiber exposure", disregarding the main conclusion: "Chrysotile asbestos, along with all other types of asbestos, has caused mesothelioma" [76]. It was reasonably concluded that by failing to analyze or even mention contradicting data, Bernstein et al did not provide an objective analysis, and have created the impression that they have published a document to support the interests of chrysotile producers [56,67].…”

“…on the Wittenoom cohort studies seems to be compelling [81][82][83], although the number of deaths with mesothelioma in men in the period 1987 to 2008 remained similar to the lowest predictions (the number of Mt in the past 8 years was higher than predicted -74 vs. 63) [83], while genetic predisposition was discussed along with asbestos as an etiologic factor of Mt [84]. There is considerable evidence that the risk of Mt is enhanced after exposure to chrysotile without amphibole admixture [46,48,[72][73][74][75][76]85]. There has been also an alternate view [86,87] e.g.…”

Peritoneal Mesothelioma and Asbestos: Clarifying the Relationship by Epidemiology

“…There are many cases of peritoneal mesothelioma in cohorts of chrysotile exposed populations with a significant excess of mesothelioma, and peritoneal mesotheliomas have been well documented in chrysotile exposed populations [1].…”

“…We previously updated the epidemiology of mesothelioma in relation to asbestos [1]. That review emphasized the most common type of mesothelioma, pleural.…”

Interação célula-crisotila em duas diferentes linhagens celulares: uma abordagem morfológica e molecular.

“…Porém, fragmentos menores que 5μm são capazes de atravessar o pulmão e alcançar a pleura, podendo acumular-se neste tecido ou serem translocadas para outras regiões do corpo, como nódulos linfáticos e tecidos mesoteliais. O acúmulo dessas fibras de crisotila na região pleural é frequentemente observado em mesoteliomas e placas pleurais, sugerindo que as fibras de crisotila são capazes de induzir mesoteliomas malignos (KANAREK, 2011;SUZUKI;YUEN, 2001). …”