Mesothelioma Mortality Rates in Greece for the Period 2005–2015 Is Increased Compared to Previous Decades

Gogou, Evdoxia; Hatzoglou, Chrissi; Zarogiannis, Sotirios G.; Malli, Foteini; Jagirdar, Rajesh; Gourgoulianis, Konstantinos

doi:10.3390/medicina55080419

Cited by 7 publications

(11 citation statements)

References 24 publications

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“…On the other hand, asbestos is a natural nanomaterial that was widely used in buildings from the 1950s to the 1970s for its exceptional heat insulation [10] (Figure 1b), fire resistance, and sound insulation; however, inhalation exposure to asbestos nanoparticles has been shown to cause malignant tumors, such as pleural mesothelioma, and their use was prohibited in various countries [11][12][13][14]. Inhaled asbestos nanoparticles are believed to cause long-term inflammation in the lungs, malignant transformation of mesothelial cells as a result of their reactivity, and formation of malignant mesothelioma [15].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials

Aoki

2020

Nanomaterials

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With the development of nanotechnology in recent years, there have been concerns about the health effects of nanoparticles. Carbon nanotubes (CNTs) are fibrous nanoparticles with a micro-sized length and nano-sized diameter, which exhibit excellent physical properties and are widely studied for their potential application in medicine. However, asbestos has been historically shown to cause pleural malignant mesothelioma and lung cancer by inhalation exposure. Because carbon nanotubes are also fibrous nanotubes, some have raised concerns about its possible carcinogenicity. We have reported that there is no clear evidence of carcinogenicity by local and intravenous administration of multi-walled CNTs to cancer mice models. We firmly believe that CNTs can be a safe, new, and high-performance biomaterials by controlling its type, site of administration, and dosage.

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Section: Introductionmentioning

confidence: 99%

Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials

Aoki

2020

Nanomaterials

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“…Entre as DRAs que acometeram os trabalhadores desta pesquisa, destaca-se a prevalência do MM, doença com rápida evolução, cujo período de latência depende do tempo de exposição, podendo ter uma latência de até 50 anos 21,27,47,48 . Observou-se, em um estudo realizado na Bélgica em 2015, que a mortalidade por MM foi maior entre os trabalhadores manuais em indústrias de amianto 22 .…”

Section: Discussionunclassified

“…Of the ARDs that affect the workers included in this research, it is worth noting the prevalence of MM, a rapidly evolving disease whose period of latency depends on time of exposure and may reach up to 50 years. 21 , 27 , 47 , 48 A study conducted in Belgium in 2015 showed that mortality for MM was higher among blue-collar asbestos workers. 22 …”

Section: Discussionmentioning

confidence: 99%

Occupational characterization of workers exposed to asbestos: an integrative review

Vicari¹,

Ribeiro²,

Aguiar³

et al. 2022

Rev Bras Med Trab

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RESUMO | O asbesto é uma fibra mineral abundante na natureza, classificado como substância cancerígena desde 1987. Objetivouse identificar, na literatura científica, quais são as ocupações e atividades desenvolvidas por trabalhadores adoecidos e quais categorias seriam afetadas com doenças relacionadas ao asbesto. O presente estudo trata-se de uma revisão de literatura realizada mediante a busca nas bases de dados PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science e Portal Regional da Biblioteca Virtual em Saúde, sendo selecionados e avaliados 23 estudos publicados entre 2015 e 2020. As ocupações que demonstraram maior adoecimento pela exposição ao asbesto foram trabalhadores gerais de indústrias de asbesto (40%), mineradores (22%) e do setor têxtil (9%), seguidos por trabalhadores da indústria naval, do setor automotivo, carpinteiros, do setor de fabricação de bonecas, da construção civil, estofadores e trabalhadores que participaram do resgate, recuperação, limpeza e restauração do local do World Trade Center (4%). Entre as patologias associadas à exposição ao asbesto, a principal descrita é o mesotelioma maligno (43%). As evidências encontradas corroboram as informações preexistentes na literatura de que a exposição ao asbesto pode ser prejudicial à saúde. Ainda, ressalta-se a importância da utilização de equipamentos de proteção individual, a fim de evitar o desenvolvimento de doenças relacionadas ao asbesto. Palavras-chave | asbesto; ocupações; exposição ocupacional; saúde do trabalhador.ABSTRACT | Asbestos is a mineral fiber abundant in nature and classified as a carcinogen since 1987. The present study aimed to identify, in the scientific literature, what are the occupation and activities developed by sick workers and which categories would be affected with asbestos-related diseases. Through a literature review performed in the following databases: PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, and Regional Portal of the Virtual Health Library, 23 studies published from 2015 to 2020 were selected and evaluated. The occupations that showed greater illness due to exposure to asbestos were general asbestos workers (40%), miners (22%), and textile workers (9%), followed by naval, automotive, carpentry, doll-making, construction, and upholstery workers, as well as workers involved in the rescue, recovery, cleaning, and restoration of the World Trade Center (4%). Of the disease associated with exposure to asbestos, the most described is malignant mesothelioma (43%). Evidence found corroborate pre-existing information in the literature showing that exposure to asbestos may be harmful to health. Moreover, the importance of using personal protective equipment was emphasized, in order to prevent the development of asbestos-related diseases.

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“…Incidence across the EU is variable. National epidemiological studies in Poland analysing the incidence of asbestos-related diseases in the period of 1970-2015 revealed a decline in cases (20), whereas in Greece there was an increasing trend (21). A possible explanation is that the use of asbestos was banned at different times (22,23).…”

Section: Discussionmentioning

confidence: 99%

Asbestos danger in central Europe is not yet over - the situation in the Czech Republic

Urban¹,

Pelclová²,

Urban³

et al. 2022

Cent Eur J Public Health

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Objectives: In the Czech Republic, asbestos has been classified as a known human carcinogen since 1984. The use of asbestos-containing products was limited to scenarios where the use of other materials was not possible. Since 1997, the manufacture of asbestos materials has been forbidden, and in 1999, the import, manufacture and distribution of all types of asbestos fibres was legally banned by Act No. 157/1998 Coll. Although the use of asbestos is forbidden, the risk of exposure still exists given the ongoing demolition and reconstruction of buildings in which asbestos has been used. In addition, a novel risk has arisen through the quarrying of asbestos-containing aggregates and their subsequent use. The aim of this paper was to describe and evaluate asbestos in terms of history, legislation, current risk of occupational exposure and its health consequences in the Czech Republic over the last three decades.Methods: This retrospective descriptive study used the collected data on occupational exposure and occupational diseases. The counts of workers occupationally exposed to asbestos were obtained from the Registry of Work Categorization; the numbers and structure of occupational diseases caused by asbestos were taken from the Czech National Registry of Occupational Diseases. Data on the total number of mesothelioma cases recorded in the Czech National Cancer Registry was provided by the Institute of Health Information and Statistics of the Czech Republic.Results: A total of 13,112 subjects were registered as occupationally exposed to asbestos during the period 2001-2020. A total of 687 cases of asbestos-related occupational diseases were reported in the period 1991-2020 in the Czech Republic, comprising 178 cases of asbestosis, 250 cases of pleural hyalinosis, 168 cases of pleural or peritoneal mesothelioma, 90 cases of lung cancer, and one case of laryngeal cancer. The data from the Czech National Cancer Registry, available for a shorter period , reveal 1,389 cases of mesothelioma, of which only ~11% were recognised as occupational, despite the fact that the occupational causality of mesotheliomas is estimated to be up to 90% of mesotheliomas. Moreover, the latency of mesotheliomas since the last occupational exposure reached up to 50 years and this trend is still slightly increasing, unlike asbestosis, where a high cumulative dose of inhaled asbestos is needed. The real proportion of occupational lung cancers may obviously be even higher, especially in smokers, where occupational causes including asbestos are not suspected by most physicians.Conclusion: Czech data on asbestos-related occupational diseases, especially cancers, are grossly underestimated, which is most apparent through the low proportion of mesotheliomas diagnosed as occupational. Asbestos materials in older buildings remained in situ and may represent a danger during reconstruction works. The current source of exposure appears to be quarrying of asbestos-containing aggregate and its subsequent use. Awareness of the professional community is ther...

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Mesothelioma Mortality Rates in Greece for the Period 2005–2015 Is Increased Compared to Previous Decades

Cited by 7 publications

References 24 publications

Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials

Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials

Occupational characterization of workers exposed to asbestos: an integrative review

Asbestos danger in central Europe is not yet over - the situation in the Czech Republic

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