Mesothelioma of childhood

Fraire, Armando E.; Cooper, Sharon P.; Greenberg, S. Donald; Buffler, Patricia A.; Langston, Claire

doi:10.1002/1097-0142(19880815)62:4<838::aid-cncr2820620433>3.0.co;2-9

Cited by 98 publications

(58 citation statements)

References 67 publications

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“…A few cases have been described before the fourth decade of life in patients exposed to asbestos during childhood. The tumour can occur rarely in children [49] and a number of these cases probably has no relation to asbestos. The previously mentioned strong male predominance is due to the fact that exposure to asbestos is less common in females.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Malignant pleural mesothelioma

Boutin¹,

Schlesser²,

Frenay³

et al. 1998

Eur Respir J

171

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The incidence of malignant pleural mesothelioma (MPM) has risen for some decades and is expected to peak between 2010 and 2020. Up to now, no single treatment has been proven to be effective and death usually occurs within about 12-17 months after diagnosis. Perhaps because of this poor prognosis, early screening has incited little interest. However, certain forms may have a better prognosis when diagnosed early and treated by multimodal therapy or intrapleural immunotherapy. Diagnosis depends foremost on histological analysis of samples obtained by thoracoscopy. This procedure allows the best staging of the pleural cavity with an attempt to detect visceral pleural involvement, which is one of the most important prognostic factors. Although radiotherapy seems necessary and is efficient in preventing the malignant seeding after diagnostic procedures in patients, there has been no randomized phase III study showing the superiority of any treatment compared with another. However, for the early-stage disease (stage I) a logical therapeutic approach seems to be neoadjuvant intrapleural treatment using cytokines. For more advanced disease (stages II and III) resectability should be discussed with the thoracic surgeons and a multimodal treatment combining surgery, radiotherapy and chemotherapy should be proposed for a randomized controlled study. Palliative treatment is indicated for stage IV. In any case, each patient should be enrolled in a clinical trial.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Malignant pleural mesothelioma

Boutin¹,

Schlesser²,

Frenay³

et al. 1998

Eur Respir J

171

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“…The occurrence of mesothelioma in childhood leads to similar conclusions. Evidence of such cases was found in three surveys, the largest of which by FRAIRE et al [64] recorded 80 cases in childhood, in only two of which was exposure to asbestos at all likely. Unless the usual latency with asbestos-related cases is much shorter in childhood, the existence of these cases suggests that there must have been some other cause.…”

Section: The Background Hypothesismentioning

confidence: 99%

The epidemiology of mesothelioma in historical context

Jc¹,

McDonald²

1996

Eur Respir J

193

109

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T Th he e e ep pi id de em mi io ol lo og gy y o of f m me es so ot th he el li io om ma a i in n h hi is st to or ri ic ca al l c co on nt te ex xt tThe epidemiology of mesothelioma in historical context. J.C. McDonald, A.D. McDonald. ©ERS Journals Ltd 1996. ABSTRACT: Primary malignant mesothelial tumours were recognized by pathologists before asbestiform minerals (chrysotile, crocidolite and amosite) were mined commercially. The discovery, 40 yrs ago, of a causal link with crocidolite and the wide-ranging epidemiological studies which followed are the subject of this review.Early case-control and descriptive surveys, supplemented by cohort studies in insulation workers and chrysotile miners, quickly demonstrated major occupational and geographical differences, with high risk in naval dockyard areas and in the heating trades. In the 1980s, reliable cohort surveys showed that in mining and in the manufacture of asbestos products the mesothelioma risk was much higher when exposure included crocidolite or amosite than chrysotile alone. However, qualitative and quantitative information on exposure was too often inadequate for this evidence to be conclusive. Well-controlled lung fibre analyses have reduced these deficiencies and demonstrated the probable implications of the greater biopersistence of amphibole fibres. Chrysotile for industrial use often contains low concentrations of fibrous tremolite, which may well explain the few cases of mesothelioma associated with this type of asbestos.Progress in this field has been much retarded by controversy, for which the 20 year gap between the availability of reliable estimates of risk for the mining of chrysotile and that for crocidolite or amosite may have been largely responsible.

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“…In this patient, a biopsy of the nodules on the pleura showed typical histopathologic features of the epithelial type of MPM. The tumor mainly affects older men who were occupationally exposed to asbestos at early ages, but malignant mesothelioma can also occur in children (14). In contrast to previous reports, this patient was young and had none of the wellestablished risk factors for MPM.…”

Section: Discussionmentioning

confidence: 99%

Non-Asbestos-related Malignant Pleural Mesothelioma

et al. 2014

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Malignant pleural mesothelioma (MPM) is an uncommon tumor derived from mesothelial lining cells. MPM has been described as an insidious neoplasm because of its long latency period. The tumor is typically found in patients several decades after asbestos exposure. We herein describe a 26-year-old patient with MPM who presented with pleural effusion. The patient had not been exposed to asbestos or erionite. There are few case reports of non-asbestos-related MPM in young patients. We report this case to remind physicians to consider MPM in the differential diagnosis of pleural effusion in young patients without exposure to asbestos or erionitis.

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Mesothelioma of childhood

Cited by 98 publications

References 67 publications

Malignant pleural mesothelioma

Malignant pleural mesothelioma

The epidemiology of mesothelioma in historical context

Non-Asbestos-related Malignant Pleural Mesothelioma

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