Mesotrione herbicide does not cause genotoxicity, but modulates the genotoxic effects of Atrazine when assessed in mixture using a plant test system (Allium cepa)

Felisbino, Karoline; Santos-Filho, Ronaldo; Piancini, Laércio Dante Stein; Cestari, Marta Margarete; Leme, Daniela Morais

doi:10.1016/j.pestbp.2018.07.009

Cited by 26 publications

(12 citation statements)

References 48 publications

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“…When studying the effect of pesticides of various concentrations on the growth of wheat roots, it turned out, that with the exception of metribuzin, all fungicides and herbicides signi cantly inhibited root growth, starting from a concentration of 0.10 µg / mL.It should be noted, that the analysis of literature data on the effect of pesticides on the cytogenetic rearrangements of higher plants, showed a huge (by orders of magnitude) spread of data on the studied concentrations from very high: 0.5-2.0 mg/mL [20] and 5.0-15.0 mg/ml [45] to very low: 0.002-0.4 µg/mL [46]. The authors of the works did not motivate the choice of concentrations, but noted the cytotoxic effects of pesticides, which were detected for both, high and low concentrations.…”

Section: Discussionmentioning

confidence: 90%

Cytological Effects of Herbicidal and Fungicidal Pesticides on Root Apex Meristem Cells of Triticum Aestivum

Menzyanova

Shishatskaya

Pyatina

et al. 2020

Preprint

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Using the example of 2-day-old Triticum aestivum seedlings, grown in hydroponic culture, the cytological effects of pesticides with various mechanisms of the damaging were studied: the herbicides metribuzin, tribenuron-methyl, fenoxaprop-P-ethyl and the fungicides tebuconazole, epoxiconazole, and azoxystrobin. All pesticides showed a dose-dependent inhibitory effect on the development of the roots of Triticum aestivum, but did not affect the mitotic activity and did not reduce the mitotic index of root apex meristem cells. Herbicides and fungicides affected the duration of metaphase, anophase, prophase, and cytokinesis activity in the root apex meristem of the wheat, and these changes were specific for the six studied preparations. Under the influence of all pesticides, the number of abnormal cells increased significantly, to the greatest extent (10–12 times compared with control - distilled water) under the influence of herbicides tribenuron-methyl and phenoxaprop-ethyl and fungicides azoxystrobin and epoxiconazole; to a lesser extent - under the influence of metribuzin and tebuconazole (6–7 times). For all studied pesticides the manifestation of cyto- and genotoxicity, including both clastogenic and aneugenic effects, was revealed in relation to the non-target plant Triticum aestivum. Under the influence of pesticides, structural anomalies, caused by chromosome breakdown (bridges, fragments, micronuclei) and spindle damage (lagging chromosomes and their fragments, uneven chromosome separation) were detected in the cells of the Triticum aestivum root apex meristem.

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Section: Discussionmentioning

confidence: 90%

Cytological Effects of Herbicidal and Fungicidal Pesticides on Root Apex Meristem Cells of Triticum Aestivum

Menzyanova

Shishatskaya

Pyatina

et al. 2020

Preprint

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“…The use of herbicides like Buta has been shown to adversely affect crop growth 3 , 9 – 11 . Consistent with these studies, Buta treatment decreased the growth of rice seedlings (Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…Besides controlling weeds, the extensive use of herbicides may also affect other crop plants and thus may negatively impact their productivity. Herbicides indeed negatively affect seed germination, hormone synthesis, cell division, cell permeability, nutrient uptake and their assimilation, as well as lipid and protein metabolism 1 , 6 – 11 . García-Garijoet al 12 have observed that imazamox, a herbicide, drastically decreased root nodule biomass in Phaseolus vulgaris and Vicia sativa , thereby affecting their nitrogen balance.…”

Section: Introductionmentioning

confidence: 99%

Silicon tackles butachlor toxicity in rice seedlings by regulating anatomical characteristics, ascorbate-glutathione cycle, proline metabolism and levels of nutrients

Tripthi

Varma

Singh

et al. 2020

Sci Rep

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Reckless use of herbicides like butachlor (Buta) in the fields represents a serious threat to crop plants, and hence to their productivity. Silicon (Si) is well known for its implication in the alleviation of the effects of abiotic stresses; however, its role in mitigating Buta toxicity is not yet known. Therefore, this study was carried out to explore the role of Si (10 µM) in regulating Buta (4 µM) toxicity in rice seedlings. Buta reduced growth and photosynthesis, altered nitric oxide (NO) level and leaf and root anatomy, inhibited enzyme activities of the ascorbate-glutathione cycle (while transcripts of associated enzymes, increased except OsMDHAR ), as well as its metabolites (ascorbate and glutathione) and uptake of nutrients (Mg, P, K, S, Ca, Fe, etc. except Na), while addition of Si reversed Buta-induced alterations. Buta stimulated the expression of Si channel and efflux transporter genes- Lsi1 and Lsi2 while the addition of Si further greatly induced their expression under Buta toxicity. Buta increased free proline accumulation by inducing the activity of Δ 1 -pyrroline-5-carboxylate synthetase (P5CS) and decreasing proline dehydrogenase (PDH) activity, while Si reversed these effects caused by Buta. Our results suggest that Si-governed mitigation of Buta toxicity is linked with favorable modifications in energy flux parameters of photosynthesis and leaf and root anatomy, up-regulation of Si channel and transporter genes, ascorbate-glutathione cycle and nutrient uptake, and lowering in oxidative stress. We additionally demonstrate that NO might have a crucial role in these responses.

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“…number of cells in division , while the observation of micronuclei and chromosomal aberration, such as bridges, fragments and vagrant, allows estimating the genotoxic effects of agents. This test system has shown high sensitivity in detecting environmental chemicals (LEME & MARIN-MORALES, 2009), and has successfully been used to evaluate the genotoxicity of sludge samples (RANK & NIELSEN, 1998;MARTINS et al, 2016;SOMMAGGIO et al, 2018), hospital wastewaters (MAGDALENO et al, 2014), herbicides FELISBINO et al, 2018), petroleum refinery wastewaters (HOSHINA et al, 2009) and rivers (GOMES et al, 2015;RODRIGUES et al, 2016).…”

Section: Metodologiamentioning

confidence: 99%

Análise Multitemporal Do Desmatamento Por Ndvi Do Município De Rondon Do Pará Nos Anos De 2007 E 2017

Cardoso¹,

Teixeira²,

Júnior³

et al. 2019

Educação, Meio Ambiente E Território 3

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Mesotrione herbicide does not cause genotoxicity, but modulates the genotoxic effects of Atrazine when assessed in mixture using a plant test system (Allium cepa)

Cited by 26 publications

References 48 publications

Cytological Effects of Herbicidal and Fungicidal Pesticides on Root Apex Meristem Cells of Triticum Aestivum

Cytological Effects of Herbicidal and Fungicidal Pesticides on Root Apex Meristem Cells of Triticum Aestivum

Silicon tackles butachlor toxicity in rice seedlings by regulating anatomical characteristics, ascorbate-glutathione cycle, proline metabolism and levels of nutrients

Análise Multitemporal Do Desmatamento Por Ndvi Do Município De Rondon Do Pará Nos Anos De 2007 E 2017

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