Genetic modification is a specific part of gene technology that changes the genetic structure of living organisms, such as animals, plants, or microorganisms. Genetically Modified, is known with such names as Transgenic or Transgenic. In recent years, discussions have arisen about the potential effects of transgenic corn on health There are also discussions about its effect on other insects and other plants due to the gene flow The study was conducted as a systematic double-blind review by searching the Internet at the Google Scholar, PubMed, Science Direct, Medline, Highwire, MD Consult and Scopus databases. From the result of this study, we can come to a Conclusion that any transgenic product is not usable and can have many disadvantages, while some of them are completely safe and usable.