Messung der Kollateraldurchblutung am Hundeherzen mit Hilfe der selektiven Embolisierung eines Coronargef��es

Schulz, F; Raff, W. K.; Meyer, Ulrich; Lochner, W.

doi:10.1007/bf00592793

Cited by 20 publications

(11 citation statements)

References 33 publications

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“…described by Sehulz and Lochner and allows to subdivide the total coronary resistance into defined parts: preeollateral, posteollateral, collateral and nutritive resistance (19). These different parts react differently to pharmacological dilatation.…”

Section: Discussionmentioning

confidence: 99%

The pressure-resistance relationships of regional resistances within the coronary circulation and the steal phenomenon

et al. 1978

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On narcotized dogs the descending branch of the left coronary artery was ligated and the peripheral vascular bed embolized with microspheres. A maximal phar. macological dilatation was induced with carbochromen and dipyridamol and the pressure flow relation of the regional resistances within the coronary circulation investigated. An increase in the aortic pressure from 100 to 120 mmI-Ig decreased the total resistance of the circumflex branch by 6%. The precollateral resistance, however, which represents chiefly the resistance of large coronary vessels, at the same time increased by 8%.A decrease with increasing pressure was also shown by the nutritive resistance (chiefly resistance of small vessels and arteriols) and the collateral resistance (resistance of spontaneous collaterals). An increase in perfusion pressure from 70 to 90 mmHg diminished the nutritive resistance by 13% and the collateral resistance by 17%.In the course of an increase in aortic pressure, collateral flow decreased if the relationship precollateral resistance/postcollateral resistance (RJR~) on one hand and collateral resistance/nutritive resistance 1~/1~ on the other hand increased. Collateral flow, however, increased when the quotients RI/R 4 and R3/R 2 remained either unchanged or decreased, when aortic pressure was enhanced.From these results it can be concluded that not every increase in aortic pressure necessarily leads to an increase in collateral flow. A decrease in collateral flow, which can produce the steal phenomenon, can also develop in the follow of an increase in aortic pressure in as much as the regional resistances which influence collateral flow are changed correspondingly.The importance of the perfusion pressure for the blood flow in spontaneous collaterals has been repeatedly described (2,6,7, 11,13,17,18). In an earlier investigation on narcotized dogs with an acute infarct we *) The paper was supported by the Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 30, Dfisseldorf.

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Section: Discussionmentioning

confidence: 99%

The pressure-resistance relationships of regional resistances within the coronary circulation and the steal phenomenon

et al. 1978

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“…It might be expected that the ischernic vascular bed ist maximally dilated and thus represents a minimal part of the resistance to collateral blood flow (19). However, mean pressure in a coronary artery beyond the site of occlusion (PPC) can be as high as 11 to 32 mmHg (11,19,20,21,24,26). These high pressures imply that the resistance of the ischemic vascular bed may not be insignificant.…”

Section: Introductionmentioning

confidence: 99%

“…Downey and Kirk demonstrated a vascular waterfall mechanism in the coronary circulation of the beating heart (5), suggesting that if the pressure to a given coronary vessel drops below a certain critical level, blood flow *) This study was supported in part by DFG grant Er 100/3-1 ceases. Thus retrograde flow represented total collateral flow and outflow pressure of retrograde flow (PRF) could be varied without draining blood into the ischemic bed (4,6,21,24,25). However, it has not been shown if a critical pressure also exists for collateral vessels.…”

Section: Introductionmentioning

confidence: 99%

“…At this critical pressure, the resistance of the vascular bed would become very large. When retrograde flow is interrupted, pressure in the occluded coronary artery represents the pressure in the ischemic borderzone, i.e., the collateral perfusion pressure (CPP) (4,6,21,24,25). Since collaterals are vessels with a minireal density of smooth muscle, they could be considered "collapsible tubes", and a waterfall phenomenon could also apply to the collateral vasculature.…”

Section: Introductionmentioning

confidence: 99%

“…However, it has not been shown if a critical pressure also exists for collateral vessels. Collateral resistance can thus be determined from the pressure across the collateral bed and retrograde flow (4,6,21,24,25). Thus collateral blood flow would not depend on PPC in the ischemic bed, since: Collateral Blood Flow = (CPP-Surrounding Tissue Pressure)/Collateral Resistance (17).…”

Section: Introductionmentioning

confidence: 99%

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Influence of the ischemic coronary bed on collateral blood flow

et al. 1982

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The purpose of this study was to determine the influence of the resistance of the terminal vascular bed of an occluded coronary artery on collateral blood flow and collateral resistance. In 6 anesthetized dogs, left anterior descending coronary artery (LAD) was ligated, cannulated, and the terminal vascular bed was occluded by latex microspheres (diameter: 25 mu). Retrograde flow was measured using a new technique, which allowed control of outflow pressure of retrograde flow (PRF) at the LAD cannula. When retrograde flow was interrupted, pressure in the occluded vessel represented collateral perfusion pressure (CPP) within the border zone of the ischemic vessel. Collateral resistance was determined dividing the pressure difference across the collateral bed (CPP-PRF) by retrograde flow. Variation of PRF was used as a model for changes in resistance of the ischemic bed. Retrograde flow fell when PRF was increased from 11.0 +/- 3.0 ml X min-1 X 100 g-1 (PRF = 0) to 8.3 +/- 2.4 (p less than 0.01)(PRF = 24.6 +/- 6 mm Hg). For the same PRF range, collateral resistance fell from 9.68 +/- 2.96 to 8.30 +/- 2.50 mm Hg X ml-1 X min X 100 g (p less than 0.01). These results indicate that the vascular resistance of the terminal ischemic bed may considerably influence collateral blood flow and resistance.

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Early Arrhythmias and Primary Ventricular Fibrillation after Acute Myocardial Ischaemia in Relation to Pre-existing Coronary Collaterals

Meesmann¹

1982

Early Arrhythmias Resulting From Myocardial Ischaemia

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Messung der Kollateraldurchblutung am Hundeherzen mit Hilfe der selektiven Embolisierung eines Coronargef��es

Cited by 20 publications

References 33 publications

The pressure-resistance relationships of regional resistances within the coronary circulation and the steal phenomenon

The pressure-resistance relationships of regional resistances within the coronary circulation and the steal phenomenon

Influence of the ischemic coronary bed on collateral blood flow

Early Arrhythmias and Primary Ventricular Fibrillation after Acute Myocardial Ischaemia in Relation to Pre-existing Coronary Collaterals

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