Messung der Leberschädigung durch Perchlorethen mit Hilfe des <i>in vivo</i> [<sup>15</sup>N]Methacetin-Urintests

Krumbiegel, P.; Kulicke, K.; Rasenberger, U.; Starke, M.

doi:10.1080/00211919208050800

Isotopenpraxis Isotopes in Environmental and Health Studies

1992

DOI: 10.1080/00211919208050800

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Messung der Leberschädigung durch Perchlorethen mit Hilfe des in vivo [¹⁵N]Methacetin-Urintests

P. Krumbiegel

K. Kulicke

U. Rasenberger³

et al.

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Cited by 3 publications

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“…However, the test is not specific to the source of the disturbance. The [ 15N]methacetin urine test has been used to assess alterations of detoxification capacities caused by various known external sources, e.g., drugs [4], occupational pollutants [5] and environmental pollutants, such as sulfur dioxide [6,7] and airborne lead-loaded dust [8]. In the studies, one 'indicator component' predominated throughout the study lasting a few years [9].…”

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The [¹⁵N]Methacetin Liver Function Test Characterizes Multicomponent Exposure of Children in Industrially Polluted Regions

Rehwagen

Krumbiegel

Koschny³

et al. 2001

Isotopes in Environmental and Health Studies

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The [15N]methacetin urine test for assessing disturbances of the cytochrome P450-aided oxygenation of xenobiotics in the human liver has been approved in several environmental health studies. A recent longitudinal study of kindergarten children near chemical and mining companies undergoing fundamental restructuring showed high, seasonally fluctuating SO2 burden which was well correlated with alterations in the mean liver states of the children. At one point the correlation disappeared, together with indications of large amounts of chlorinated compounds overflowing locally at nighttime. This was finally proven by analyzing urine samples from the children for trichloroacetic acid (TCA). Chlorinated ethanes and ethenes-the precursors of TCA-seemed to dominate the air pollution and to affect the hepatic detoxification capacity. We concluded that the methacetin liver function test reflects multicomponent exposure, including acute monopolization by a dominant pollutant for a time.

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confidence: 99%

The [¹⁵N]Methacetin Liver Function Test Characterizes Multicomponent Exposure of Children in Industrially Polluted Regions

Rehwagen

Krumbiegel

Koschny³

et al. 2001

Isotopes in Environmental and Health Studies

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¹⁵Nmethacetin test to control liver function of infants with formerly very low birth weight

Krumbiegel

Richter

1993

Isotopenpraxis Isotopes in Environmental and Health Studies

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Hepatic detoxification capacities of three groups of infants aged about two were estimated using the [' 5N]methacetin elimination test, as well as standard serum parameters: 1. Formerly hypotrophically born infants still too small for their age (n = 23) 2. Patients suffering from severe liver diseases (n = 15) 3 . Patients without liver diseases (n = 14).17 of the infants of group 1 showed I5N elimination rates as low as the rates of the liver-diseased patients of group 2. Compared to the infants of group 3, who had normal values, the findings reflcct diminished hepatic monooxygenases activities in groups 1 and 2. On the other hand, the serum parameters of the infants of group 1 did not deviate from normal values estimated in group 3 . Here only group 2 showed pathological values.Consequcntly, the ['5N]methacetin test seems to be more sensitive in controlling hepatic parametcrs of growth retardations than the usual serum parameters used here. Further investigations have to answer thc question to which proportion intrauterine malnutrition and postnatal effects, such as environmental living conditions, contribute to the retardation of liver function development in combination with growth retardation.

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Evaluating environmental exposure on children: How can stable isotope techniques contribute?

Krumbiegel

Berthold

1993

Isotopenpraxis Isotopes in Environmental and Health Studies

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Messung der Leberschädigung durch Perchlorethen mit Hilfe des in vivo [¹⁵N]Methacetin-Urintests

Cited by 3 publications

References 1 publication

The [¹⁵N]Methacetin Liver Function Test Characterizes Multicomponent Exposure of Children in Industrially Polluted Regions

The [¹⁵N]Methacetin Liver Function Test Characterizes Multicomponent Exposure of Children in Industrially Polluted Regions

¹⁵Nmethacetin test to control liver function of infants with formerly very low birth weight

Evaluating environmental exposure on children: How can stable isotope techniques contribute?

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Messung der Leberschädigung durch Perchlorethen mit Hilfe des in vivo [15N]Methacetin-Urintests

Cited by 3 publications

References 1 publication

The [15N]Methacetin Liver Function Test Characterizes Multicomponent Exposure of Children in Industrially Polluted Regions

The [15N]Methacetin Liver Function Test Characterizes Multicomponent Exposure of Children in Industrially Polluted Regions

15Nmethacetin test to control liver function of infants with formerly very low birth weight

Evaluating environmental exposure on children: How can stable isotope techniques contribute?

Contact Info

Product

Resources

About

Messung der Leberschädigung durch Perchlorethen mit Hilfe des in vivo [¹⁵N]Methacetin-Urintests

The [¹⁵N]Methacetin Liver Function Test Characterizes Multicomponent Exposure of Children in Industrially Polluted Regions

The [¹⁵N]Methacetin Liver Function Test Characterizes Multicomponent Exposure of Children in Industrially Polluted Regions

¹⁵Nmethacetin test to control liver function of infants with formerly very low birth weight