MET promotes the proliferation and differentiation of myoblasts

Li, Yongyong; Zhou, Hang; Yu-yu, Chen; Zhong, Dongmei; Su, Peiqiang; Yuan, Haodong; Xiaoming, Yang; Liao, Zhiheng; Qiu, Xianjian; Wang, Xudong; Liang, Tongzhou; Gao, Wenjie; Shen, Xiaofang; Zhang, Xin; Lian, Chengjie; Xu, Caixia

doi:10.1016/j.yexcr.2020.111838

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…We used ChIRP to determine the sites in the genome where MUNC binds and looked for cases where MUNC also regulates adjoining gene expression to find potentially direct targets of MUNC . Distinct combinations of MUNC domains are required for binding to and induction of Dcn (CH1 and CH5), Met (CH2 and CH5), and Runx1 (CH5 and SH1), genes that are known to stimulate muscle differentiation ( Li et al, 2020b ; Umansky et al, 2015 ; Wang et al, 2005 ; Kishioka et al, 2008 ). Similarly, different domains were critical for downregulation of Il15 (CH1, CH3, and PR2), Prmt6 (SH1), and Grip1 (CH4), genes that are known to have a negative impact on skeletal muscles ( Quinn et al, 1995 ; Choi et al, 2019 ; Wu et al, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

et al. 2022

View full text Add to dashboard Cite

“…Distinct combinations of MUNC domains are required for binding to and induction of Dcn (CH1 and CH5), Met (CH2 and CH5), and Runx1 (CH5 and SH1), genes that are known to stimulate muscle differentiation (Kishioka et al, 2008;Li et al, 2020b;Umansky et al, 2015;Wang et al, 2005). Similarly, different domains were critical for downregulation of Il15 (CH1, CH3, and PP2), Prmt6 (SH1), and Grip1 (CH4), genes that are known to have negative impact on skeletal muscles (Choi et al, 2019;Quinn et al, 1995;Wu et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

Przanowska

Weidmann

Saha

et al. 2021

Preprint

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Many lncRNAs have been discovered using transcriptomic data, however, it is broadly unclear what fraction of lncRNAs are functional and what structural properties affect their phenotype. MUNC lncRNA, also known as DRReRNA, stimulates skeletal muscle differentiation. The prevailing hypothesis is that MUNC stimulates the Myod1 gene in cis as an enhancer RNA and stimulates expression of several other promyogenic genes in trans by recruiting the cohesin complex to their promoters. Experimental probing of the RNA structure revealed that MUNC contains multiple structural domains not detected by RNA structure prediction algorithms in the absence of experimental information. We discovered that these specific and structurally distinct domains are required for induction of different promyogenic genes, for binding at different genomic sites to regulate the expression of adjacent genes, and for binding the cohesin complex. Moreover, we found that induction of Myod1 or interaction with cohesin comprise only a subset of the broad regulatory impact of this lncRNA. Our study thus reveals unexpectedly complex, structure-driven functions for the MUNC lncRNA and emphasizes the importance of experimentally determined structures for understanding structure-function relationships in lncRNAs.

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circ_CSNK1E modulates airway smooth muscle cells proliferation and migration via miR-34a-5p/VAMP2 axis in asthma

Ding

Liu

et al. 2022

Cellular Signalling

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MET promotes the proliferation and differentiation of myoblasts

Cited by 5 publications

References 34 publications

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

circ_CSNK1E modulates airway smooth muscle cells proliferation and migration via miR-34a-5p/VAMP2 axis in asthma

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