Meta-análisis sobre el rendimiento diagnóstico de la tomografía por emisión de positrones con 18F-FDG en el carcinoma de células renales

Llano, Sofía Rodríguez Martínez de; Delgado-Bolton, Roberto; Jiménez-Vicioso, A.; Pérez-Castejón, M.J.; Delgado, José Luis Carreras; Ramos, Eduardo Valdés; Rotger, A.; Jiménez, F.; Alonso, Juan Carlos Gómez; Bittini, A.; Domı́nguez, Pedro; Almoguera, M I; Pérez-Vázquez, J.M.

doi:10.1157/13097378

Cited by 41 publications

(7 citation statements)

References 16 publications

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“…A false negative case of pathologic confirmed RCC is shown in Figure 4. One meta-analysis study suggested that FDG PET can be useful in detecting recurrent or metastatic RCC, with 85.7% accuracy (18). The significant variability in the uptake of FDG by RCC is partly due to the excretion of FDG via the urinary tract.…”

Section: Discussionmentioning

confidence: 99%

FDG PET or PET/CT in Evaluation of Renal Angiomyolipoma

et al. 2013

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Objective: Angiomyolipoma is the most common benign kidney tumor. However, literature describing FDG PET findings on renal angiomyolipoma (AML) is limited. This study reports the FDG PET and PET/CT findings of 21 cases of renal AML. Materials and Methods:The study reviews FDG PET and PET/CT images of 21 patients diagnosed with renal AML. The diagnosis is based on the classical appearance of an AML on CT scan with active surveillance for 6 months. The study is focused on the observation of clinical and radiographic features. Results: Six men and 15 women were included in our study. The mean age of the patients was 57.14 ± 9.67 years old. The mean diameter of 21 renal AML on CT scans was 1.76 ± 1.00 cm (Min: 0.6 cm; Max: 4.4 cm). CT scans illustrated renal masses typical of AMLs, and the corresponding FDG PET scans showed minimal FDG activities in the area of the tumors. None of the 21 AMLs showed a maximum standardized uptake value (SUV max ) greater than 1.98. No statistically significant correlation was present between SUV max and tumor size. Conclusion: Renal AMLs demonstrate very low to low uptake on FDG PET and PET/CT imaging in this study. When a fatcontaining tumor in the kidney is found on a CT scan, it is critical to differentiate an AML from a malignant tumor including an RCC, liposarcoma, and Wilms tumor. This study suggests that FDG PET or PET/CT imaging is useful for differentiating a renal AML from a fat-containing malignant tumor.

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Section: Discussionmentioning

confidence: 99%

FDG PET or PET/CT in Evaluation of Renal Angiomyolipoma

et al. 2013

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“…Martinez de Llano et al [ 4 ] evaluated the performance of FDG-PET in detecting primary, recurrent, and metastatic RCC, as reported in articles published before October 2004. Their meta-analytic study suggested that FDG-PET can be useful in restaging and detecting metastatic disease, but not in detecting primary disease.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma

et al. 2012

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Objectives: Positron emission tomography (PET) using fluorodeoxyglucose (FDG) is useful for restaging renal cell carcinoma (RCC) and detecting metastatic diseases but is less satisfactory for detecting primary disease. We evaluated whether the integration of computed tomography (CT) scans with the PET system could increase the applicability of FDG-PET for RCC. Methods: The MEDLINE databases were searched for relevant studies published since 2001. Two reviewers independently assessed the methodological quality of each study identified. We then performed a meta-analysis of the sensitivity and specificity of FDG-PET findings as reported in all the selected studies. Results: Fourteen studies were eligible for inclusion. The pooled sensitivity and specificity of FDG-PET were 62% and 88% respectively, for renal lesions. For detecting extra-renal lesions, the pooled sensitivity and specificity of FDG-PET were 79% and 90%, respectively, based on the scans, and 84% and 91% based on the lesions. The use of a hybrid FDG-PET/CT to detect extra-renal lesions increased the pooled sensitivity and specificity to 91% and 88%, respectively, with good consistency. Conclusions: For RCC, combining the FDG-PET and CT systems is helpful for detecting extra-renal metastasis rather than renal lesions. The hybrid PET/CT system has comparable sensitivity and specificity with PET in detecting extra-renal lesions of RCC. Advances in knowledge: The FDG-PET and PET/CT systems are both useful for detecting extra-renal metastasis in renal cell carcinoma.

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“…As widely known, because 18 F-FDG is physiologically accumulated and excreted in kidneys, it is not always possible to detect renal malignancies with 18 F-FDG PET. Still, there is also evidence that 18 F-FDG PET-CT is useful in detecting primary renal cancers [15] and/or metastatic RCCs [15–17] and recurrent diseases [18–21]. …”

Section: Introductionmentioning

confidence: 99%

Can Initial 18F-FDG PET-CT Imaging Give Information on Metastasis in Patients with Primary Renal Cell Carcinoma?

Lee

Hwang

Kim

et al. 2013

Nucl Med Mol Imaging

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PurposeThe aim of this study was to investigate the relationship between the maximum standardized uptake values (SUVmax) of primary renal cancers with and without metastatic lesions, if any. We also studied the relationship between the size of primary renal cancers and their SUVmax, and tried to find a clinical value of 18F-FDG PET-CT for the initial evaluation of renal cell carcinoma (RCC).MethodsThe cases of 23 patients, 16 men and 7 women, who underwent PET-CT examination before operation were retrospectively reviewed. We measured the SUVmax of the primary renal cancers and those of any existing metastatic lesions, and the size of the primary renal cancers. We compared the SUVmax of primary RCCs with metastases and those without metastases, SUVmax of primary RCC and those of metastases, and studied the correlation between the size and SUVmax of primary RCCs.ResultsThe SUVmax of primary RCC of the 16 patients without metastasis ranged from 1.1 to 5.6 with a median value of 2.6. Those of the patients with metastasis ranged from 2.9 to 7.6 with a median of 5.0. The size of the all 23 primary renal cancers ranged from 1.7 cm to 13.5 cm, with a median of 4.5 cm, and their SUVmax ranged from 1.1 to 7.6, with a median of 2.9. There was a statistically significant difference between the SUVmax of the primary RCC with metastasis (5.3 ± 1.7) and those without metastasis (2.9 ± 1.0). There was a moderate positive correlation between the sizes and SUVmax of all 23 primary RCCs. However, there was no statistically significant correlation between the sizes and SUVmax of primary RCCs with metastatic lesions and the same for RCCs without metastasis. The cutoff value of SUVmax for predicting extra-renal lesion was 4.4 and that for size was 5.8 cm according to the receiver operating characteristic curves.ConclusionsThose who have primary RCC with high SUVmax are suggested to have a likelihood of metastasis. Also, there was a moderate trend of increasing value of SUVmax of primary RCC as their size increases. Physicians should beware of missing extra-renal lesions elsewhere.

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Meta-análisis sobre el rendimiento diagnóstico de la tomografía por emisión de positrones con 18F-FDG en el carcinoma de células renales

Cited by 41 publications

References 16 publications

FDG PET or PET/CT in Evaluation of Renal Angiomyolipoma

FDG PET or PET/CT in Evaluation of Renal Angiomyolipoma

Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma

Can Initial 18F-FDG PET-CT Imaging Give Information on Metastasis in Patients with Primary Renal Cell Carcinoma?

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