Meta-analyses of randomised clinical trials in oncology

Pignon, Jean-Pierre; Hill, Catherine

doi:10.1016/s1470-2045(01)00453-3

Cited by 81 publications

(56 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mantel -Haenszel -Peto statistics was performed to test for heterogeneity between studies selected for the meta-analysis and to compute weighted odds ratio. 40,41 Results…”

Section: Discussionmentioning

confidence: 95%

Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis

et al. 2002

View full text Add to dashboard Cite

No definite genetic risk factor of non-monogenic frontotemporal dementia (FTD) has yet been identified. Several groups have examined the potential association of FTD with the apolipoprotein E (APOE) gene, but the results are inconsistent. Our objective was to determine whether APOE is a risk factor of FTD, using the largest series of patients with FTD and controls analysed so far (94 unrelated patients and 392 age and sex-matched controls), and a meta-analysis. Homozygosity for the E2E2 genotype was significantly associated with FTD (odds ratio (OR)=11.3; P=0.033, exact test). After stratification on familial history (FH) for FTD, the OR for E2E2 was still found significant when analysing only patients with a positive FH (OR=23.8; P=0.019). The meta-analysis, using 10 case -control studies with available genotype or allele information, comprising a total of 364 FTD patients and 2671 controls, including the patients of the present study, did not reach statistical significance even if the E2E2 genotype was more frequent in patients than in controls (0.018 vs 0.006, respectively). Because of studies heterogeneity (Mantel-Haenszel statistics: P=0.004), we analysed on one hand the neuropathologically-confirmed studies, and on the other hand the clinical-based studies. In the neuropathologically-confirmed studies (Mantel -Haenszel statistics: P=ns), we found a significant increase of the E2 allele frequency in FTD patients (OR[E2 vs E3]=2.01; 95% CI=1.02 -3.98; P=0.04). The same result was found in the clinical-based studies, but studies heterogeneity remained. No result was significant with the E4 allele. The E2 allele

show abstract

“…Mantel -Haenszel -Peto statistics was performed to test for heterogeneity between studies selected for the meta-analysis and to compute weighted odds ratio. 40,41 Results…”

Section: Discussionmentioning

confidence: 95%

Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Forest plots of the resection effect across the trials were drawn, and heterogeneity was assessed with the Cochrane's Q statistics [32]. In the absence of heterogeneity, pooled hazard ratios were estimated using the Maentel-Haenzel-Peto fixed effects method [32].…”

Section: Discussionmentioning

confidence: 99%

Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials

Faron

Pignon

Malka

et al. 2015

European Journal of Cancer

Self Cite

121

View full text Add to dashboard Cite

“…In particular, we worked out the value of observed minus estimated number of death (O-E) and its variance for each trial. OS curves were plotted [13] and the absolute differences between experimental arm and control arm in OS were calculated as well according to method by Pignon et al [14]. Results for LRR and DMR were expressed as relative risk (RR) ratio with 95% CIs using the Mantel-Haenszel method [15].…”

Section: Discussionmentioning

confidence: 99%

Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials

et al. 2013

View full text Add to dashboard Cite

Meta-analyses of randomised clinical trials in oncology

Cited by 81 publications

References 43 publications

Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis

Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis

Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials

Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials

Contact Info

Product

Resources

About