Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians

Abstract

ABSTRACT. The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95%CI) for odds ratio (OR) = 1.20-1.79) in individuals with the T allele. The tendency was increased in the homozygous comparison (609TT versus 609CC), with an OR = 2.04 (95%CI = 1.37-3.05). Stratified analysis by study design demonstrated stronger associations in population-based studies than in hospital-based studies, 2329©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (3): 2328-2337 (2012) NQO1 gene polymorphism associated with gastric cancer risk based on OR. Ethnicity-based analysis demonstrated a significant association in Asians but not in Caucasians. Additionally, in the subgroup analyses by the type of gastric cancer, a significantly increased risk was found with all genetic models in the gastric adenocarcinoma subgroup compared to the others. We conclude that the NQO1 gene C609T polymorphism increases the risk for gastric cancer, especially in Asian populations.

The Analysis of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Polish Patients with Colorectal Cancer

“…Patients with the 609TT and the 609CC genotypes were compared and a strong correlation was observed (OR = 2.04, 95% CI = 1.37-3.05). These authors concluded that the 609C > T polymorphism of the NQO1 gene increases the risk for developing stomach cancer, especially in the Asian population [23]. Similar results were obtained by Liu et al [24] and Zhu et al [25].…”

“…In another study of the Asian population, a relationship between the 609C > T oxidoreductase (NQO1) polymorphism and gastric cancer was found and a significantly increased risk (46%) of gastric cancer (95% CI = 1.20-1.79; p < 0.001) was demonstrated in people with the T allele [23]. Patients with the 609TT and the 609CC genotypes were compared and a strong correlation was observed (OR = 2.04, 95% CI = 1.37-3.05).…”

The NQO1 rs1800566 Polymorphism and Risk of Bladder Cancer: Evidence from 6,169 Subjects

“…In fact, a number of other studies also showed that NQO1 rs1800566 polymorphism plays a different role in different cancer site and ethnicity. For example, Ding et al found that NQO1 rs1800566 polymorphism was associated with increased risk of colorectal cancer in Caucasians but not in Asians (Ding et al, 2012), while Zhang et al reported that NQO1 rs1800566 polymorphism is only associated with increased gastric cancer risk in Asians but not in Caucasians (Zhang et al, 2012). On the other hand, there were only four studies involving Asians that were included in our meta-analysis; the relative small sample size may have affected the results.…”

Systematic review/Meta-analysis NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis

“…It has been reported that the NQO1 C609T polymorphism is associated with the risk of many types of malignancies, such as cancers of the stomach [26], breast [27] and esophagus [28]. However, a meta-analysis by Guo et al .…”