Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia

Li, Jia; He, Xue; Yuan, Yuan; Zhang, Wei; Lü, Xue; Zhang, Yuhua; Li, Shaoxiang; Guan, Chunyan; Gao, Zifen; Dong, Guangbin

doi:10.1016/j.ajic.2020.06.008

Cited by 130 publications

(147 citation statements)

References 21 publications

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“…This could be due to the fact that more educated peoples have more knowledge about the disease and the recommended prevention strategies. COVID-19 severe clinical disease and death have been reported mainly in peoples with advanced age and patients who had chronic disease concomitantly (11,18). In our study, an independent association was observed between young adults and low perceived e cacy of COVID-19 prevention methods.…”

Section: Discussionsupporting

confidence: 54%

“…In our context, though not studied, one of the main reasons could be related to wrong perception of people towards the disease and the recommended prevention measures. Studies revealed that severity of COVID-19 was found to be high in patients who had chronic disease concomitantly (11,18). Thus, patients who have been living with chronic diseases should perceive as they are the most vulnerable group of peoples to COVID-19 and as much as possible they should carry out all the recommended protective measures.…”

Section: Discussionmentioning

confidence: 99%

“…Majority of infected patients were presented with mild symptoms of pneumonia like fever, cough, fatigue and dyspnea (14)(15)(16). However, small proportion of cases could develop severe form of the disease like acute respiratory distress syndrome, organ dysfunction and death (17,18). Every individual is expected to be susceptible for the novel corona virus infection.…”

mentioning

confidence: 99%

“…Every individual is expected to be susceptible for the novel corona virus infection. However, studies revealed that severity of COVID-19 was found to be high in advanced age and patients who had chronic disease concomitantly (11,16,18,19).…”

mentioning

confidence: 99%

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Perceived Efficacy of COVID-19 Prevention Measures and Intention to Use Among Chronic Disease Patients in Northeast Ethiopia, 2020

Dires

Gedamu

Tesema

2020

Preprint

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Background: The novel corona virus disease outbreak which was first detected in China is caused by sever acute respiratory syndrome corona virus 2. In Ethiopia, poor perception about COVID-19 prevention methods might be one of determinant factor to the low utilization of adopted prevention measures and increasing of cases. However, it was unknown to what extent individuals were perceived the efficacy of those measures. Hence, this study was aimed to assess perceived efficacy of COVID-19 preventive measures and intention to carry out those methods among chronic disease patients. Methods: Institutional based cross sectional study was conducted among 413 chronic disease patients from 21 July - 5 August, 2020. A pre-tested interviewer administered structured questionnaire was used for data collection. Both binary and multivariable logistic regression analyses were used and in multivariable analysis, variables were declared statistically significant at p-value of < 0.05. Results: In overall, 42.1% of participants had low perception to the efficacy of COVID-19 prevention measures and 28.3% had low intention to carry out those prevention measures. In this study, young adults (AOR=2.48; 95% CI: 1.42-4.31), male gender (AOR=2.75; 95% CI: 1.73-4.37), uneducated (AOR=3.42; 95% CI: 1.47-7.94) and face mask non-users (AOR=1.64; 95% CI: 1.03-2.61) were significantly associated with low perceived efficacy of COVID-19 prevention methods. However, male gender (AOR=2.06; 95% CI: 1.28-3.31), rural residents (AOR=1.89; 95% CI: 1.16-3.07) and patients with longer duration of chronic disease (AOR= 2.19; 95% CI: 1.19-4.01) were significantly associated with low intention to carry out COVID-19 prevention methods.Conclusion: In this study, significant proportion of patients (42%) had low perception about the efficacy of COVID-19 prevention measures and nearly one-third of participants (28.3%) had low intention to carry out those measures. Thus, interventions aimed to enhance patients’ attitude and behavioral changes on COVID-19 prevention measures have to be provided.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Perceived Efficacy of COVID-19 Prevention Measures and Intention to Use Among Chronic Disease Patients in Northeast Ethiopia, 2020

Dires

Gedamu

Tesema

2020

Preprint

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“…Temperature above 38°5 C at admission was also associated with a poor outcome in our cohort. We studied this variable, already described as a prognostic factor in COVID-19 (16,17), and especially as hyponatremia may be associated with fever. We found signi cant association between these two variables, but after multivariate analysis, only hyponatremia remains an independent risk factor.…”

Section: Discussionmentioning

confidence: 99%

Hyponatremia is Associated with Poor Outcome in COVID-19

Carvalho

Letellier

Karakachoff

et al. 2020

Preprint

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Background Hyponatremia has been described in severe acute respiratory syndrome. Our objective was to describe the impact of hyponatremia on COVID-19 patients’ outcome (intensive care unit [ICU] admission, mechanic ventilation or death). Methods According to natremia at admission, two groups were retrospectively screened: hyponatremic (< 135 mM, n = 101) or normonatremic (natremia ≥ 135 mM, n = 222) patients. Pearson’s chi-2 (qualitative variables) and Student tests (quantitative variables) were used to compare the two groups. A multiple logistic regression model was used to assess the association of outcome and patients’ data. Results Hyponatremia was generally mild. There were more male patients in the hyponatremic group (p = 0.005). Pulmonary lesions on the first thoracic CT-scanner performed during the hospitalization were significantly more extended in the hyponatremic group (p = 0.03). ICU admission, mechanic ventilation or death were significantly higher in hyponatremic compared to normonatremic patients (34 versus 14%; p < 0.001; 16% versus 5%; p = 0.002; 19 versus 9%, p = 0.021, respectively). Hyponatremia was an independent predictor of poor outcome (adjusted Odds-ratio: 2.49 [1.18–5.33, p = 0.017]). Conclusions Our study showed an independent relationship between hyponatremia at admission and transfer to ICU, use of mechanic ventilation or death in COVID-19. Hyponatremia may reflect the potential severity of underlying pulmonary lesions. Our results support the use of natremia as a simple bedside screening tool for early identification of SARS-CoV-2 infected patients at high risk of poor outcome.

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Simple prognostic factors and change of inflammatory markers in patients with severe coronavirus disease 2019: a single‐center observational study

Domi¹,

Mizunuma²,

Kuroda³

et al. 2021

Acute Medicine & Surgery

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Aim The aim of this study was to investigate the prognostic factors and evaluate the change in inflammatory markers of patients with coronavirus disease 2019 (COVID‐19) requiring mechanical ventilation. Methods This retrospective observational study conducted from April 1, 2020, to February 18, 2021, included 97 adult patients who required mechanical ventilation for severe COVID‐19 pneumonia and excluded nonintubated patients with a positive COVID‐19 polymerase chain reaction test and those who had any obvious bacterial infection on admission. All patients were followed up to discharge or death. We obtained clinical information and laboratory data including levels of presepsin, interleukin‐6, procalcitonin, and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) antibody every day. Poor outcome was defined as death or receiving a tracheostomy during hospitalization, and favorable outcome was defined as discharge after extubation. Results Differences (median [interquartile range]) were detected in age (76 [70–82] versus 66 [55–74] years), day from the onset of first symptoms to admission for mechanical ventilation (5 [3–7] versus 10 [8–12] days), and P/F ratio (i.e., ratio of arterial oxygen concentration to the fraction of inspired oxygen) after intubation (186 [149–251] versus 236 [180–296]) in patients with poor outcome versus those with favorable outcome on admission. Serum SARS‐CoV‐2 antibody levels had already increased on admission in patients with favorable outcome. We determined the day from the onset of first symptoms to admission for mechanical ventilation to be one of the independent prognostic factors of patients with COVID‐19 (adjusted odds ratio 0.69, confidence interval 0.56–0.85). Conclusion These results may contribute to understanding the mechanism of progression in severe COVID‐19 and may be helpful in devising an effective therapeutic strategy.

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Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia

Cited by 130 publications

References 21 publications

Perceived Efficacy of COVID-19 Prevention Measures and Intention to Use Among Chronic Disease Patients in Northeast Ethiopia, 2020

Perceived Efficacy of COVID-19 Prevention Measures and Intention to Use Among Chronic Disease Patients in Northeast Ethiopia, 2020

Hyponatremia is Associated with Poor Outcome in COVID-19

Simple prognostic factors and change of inflammatory markers in patients with severe coronavirus disease 2019: a single‐center observational study

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