Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder

Atagün, Murat İlhan; Drukker, Marjan; Hall, Matt G.; Altun, İlkay Keleş; Tatli, Safiye Zeynep; Gülöksüz, Sinan; Os, Jim van; Amelsvoort, Thérèse van

doi:10.1016/j.pscychresns.2020.111078

Cited by 36 publications

(33 citation statements)

References 187 publications

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“…These deficits were detected both for ERPs linked to the basic levels of sensory processing, such as P50 and N100, and for indices related to higher levels of cognitive functions, such as MMN and P3b ( 63 ). For instance, the results reported for P50, support previous evidence that sensory gating is already impaired in at-risk and early stages of schizophrenia and may reflect a diminished capacity to filter repetitive sensory signals ( 44 ). Conversely, impairments in N100 seem to be more consistent in FEP rather than HR subjects, suggesting that this type of deficit might emerge only at a morbid stage of the disorder.…”

Section: Discussionsupporting

confidence: 84%

“…A recent meta-analysis reported a consistent impairment in P50 sensory gating in FEP subjects, as compared to HCs, and highlighted that this deficit had a similar magnitude to the one reported in subjects with chronic SCZ ( 44 ). Different studies found a deficit in sensory gating, as measured with the P50 ratio, in FEP ( 143 – 146 ), FES ( 147 , 148 ), and HR subjects ( 143 , 148 , 149 ), as compared to HCs.…”

Section: Resultsmentioning

confidence: 66%

“…In the last decades, a large number of studies has highlighted how some of the abnormalities of EEG indices, reported in subjects with chronic SCZ, can also be observed in the ARMS and prodromal or early phases of schizophrenia. Previous reviews on this topic ( 25 , 44 , 62 – 68 ) have considered either at-risk/prodromal states or early stages of schizophrenia or only one specific electrophysiological index.…”

Section: Introductionmentioning

confidence: 99%

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EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

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Introduction: Electrophysiological (EEG) abnormalities in subjects with schizophrenia have been largely reported. In the last decades, research has shifted to the identification of electrophysiological alterations in the prodromal and early phases of the disorder, focusing on the prediction of clinical and functional outcome. The identification of neuronal aberrations in subjects with a first episode of psychosis (FEP) and in those at ultra high-risk (UHR) or clinical high-risk (CHR) to develop a psychosis is crucial to implement adequate interventions, reduce the rate of transition to psychosis, as well as the risk of irreversible functioning impairment. The aim of the review is to provide an up-to-date synthesis of the electrophysiological findings in the at-risk mental state and early stages of schizophrenia.Methods: A systematic review of English articles using Pubmed, Scopus, and PsychINFO was undertaken in July 2020. Additional studies were identified by hand-search. Electrophysiological studies that included at least one group of FEP or subjects at risk to develop psychosis, compared to healthy controls (HCs), were considered. The heterogeneity of the studies prevented a quantitative synthesis.Results: Out of 319 records screened, 133 studies were included in a final qualitative synthesis. Included studies were mainly carried out using frequency analysis, microstates and event-related potentials. The most common findings included an increase in delta and gamma power, an impairment in sensory gating assessed through P50 and N100 and a reduction of Mismatch Negativity and P300 amplitude in at-risk mental state and early stages of schizophrenia. Progressive changes in some of these electrophysiological measures were associated with transition to psychosis and disease course. Heterogeneous data have been reported for indices evaluating synchrony, connectivity, and evoked-responses in different frequency bands.Conclusions: Multiple EEG-indices were altered during at-risk mental state and early stages of schizophrenia, supporting the hypothesis that cerebral network dysfunctions appear already before the onset of the disorder. Some of these alterations demonstrated association with transition to psychosis or poor functional outcome. However, heterogeneity in subjects' inclusion criteria, clinical measures and electrophysiological methods prevents drawing solid conclusions. Large prospective studies are needed to consolidate findings concerning electrophysiological markers of clinical and functional outcome.

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Section: Discussionsupporting

confidence: 84%

Section: Resultsmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

et al. 2021

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“…It is also considered a protective mechanism that shields higher‐order centers from sensory inundation. Theoretically, SG is expressed as the ratio of the amplitude of the second stimulus (S2) over that of the first stimulus (S1): the S2/S1 ratio (Atagun et al., 2020; Freedman et al., 1987). A higher ratio represents a worse SG function (Cheng, Chan, Liu, et al., 2016; Patterson et al., 2008).…”

Section: Introductionmentioning

confidence: 99%

Neuromagnetic evidence of abnormal automatic inhibitory function in subjective memory complaint

Sun

Lin

Nouchi

et al. 2021

Eur J of Neuroscience

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Subjective memory complaint (SMC), a self-perceived worsening in memory capacity concurrent with normal performance on standardized cognitive assessments, is considered a risk factor for the development of Alzheimer's disease (AD). Deficient sensory gating (SG), referring to the lack of automatic inhibition of neural responses to the second identical stimulus, has been documented in prodromal and incident AD patients. However, it remains unknown whether the cognitively normal elderly with SMC demonstrate alterations of SG function compared with those without SMC. A total of 19 healthy controls (HC) and 16 SMC subjects were included in the present study. Neural responses to the auditory paired-stimulus paradigm were recorded by the magnetoencephalography and analyzed by the distributed source imaging method of minimum norm estimate. The SG of M50 and M100 components were measured using the amplitude ratio of the second response over the first response at the cortical level. Compared to HC, subjects with SMC showed significantly increased M50 SG ratios in the inferior parietal lobule (IPL). Furthermore, M50 SG ratios in the right IPL yielded an acceptable discriminative ability to distinguish SMC from HC. However, we did not find a significant association between SG ratios and cognitive function requiring inhibitory control either in the HC or SMC group. In conclusion, although SMC subjects have intact cognitive functioning revealed by objective neuropsychological tests, their deficits in automatic inhibitory function could be detected | 3351 SUN et al.

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“…Several studies have focused indeed on the potential of auditory ERP components and habituation properties (e.g., P50 and P300) as diagnostic tools for schizophrenia (14,15). N1 and P2 can be particularly useful to study the mechanisms underlying the pathophysiology of schizophrenia since they are especially sensitive to early cortical auditory processing (that appears to be affected by this disorder) and seem to arise from temporal lobe generators, which are also affected in schizophrenia (9,16).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Habituation of the Auditory Event-Related Potential P2 Component in Patients With Schizophrenia

et al. 2021

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Auditory event-related potentials (ERP) may serve as diagnostic tools for schizophrenia and inform on the susceptibility for this condition. Particularly, the examination of N1 and P2 components of the auditory ERP may shed light on the impairments of information processing streams in schizophrenia. However, the habituation properties (i.e., decreasing amplitude with the repeated presentation of an auditory stimulus) of these components remain poorly studied compared to other auditory ERPs. Therefore, the current study used a roving paradigm to assess the modulation and habituation of N1 and P2 to simple (pure tones) and complex sounds (human voices and bird songs) in 26 first-episode patients with schizophrenia and 27 healthy participants. To explore the habituation properties of these ERPs, we measured the decrease in amplitude over a train of seven repetitions of the same stimulus (either bird songs or human voices). We observed that, for human voices, N1 and P2 amplitudes decreased linearly from stimulus 1–7, in both groups. Regarding bird songs, only the P2 component showed a decreased amplitude with stimulus presentation, exclusively in the control group. This suggests that patients did not show a fading of neural responses to repeated bird songs, reflecting abnormal habituation to this stimulus. This could reflect the inability to inhibit irrelevant or redundant information at later stages of auditory processing. In turn schizophrenia patients appear to have a preserved auditory processing of human voices.

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Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder

Cited by 36 publications

References 187 publications

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review

Neuromagnetic evidence of abnormal automatic inhibitory function in subjective memory complaint

Abnormal Habituation of the Auditory Event-Related Potential P2 Component in Patients With Schizophrenia

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