Meta-analysis of comparative trials for healing erosive esophagitis (EE) with proton pump inhibitors (PPIS) and H2-receptor antagonists (H2RAs)

Lansoprazole Compared With Ranitidine for the Treatment of Nonerosive Gastroesophageal Reflux Disease

“…10 The superior efficacy of proton pump inhibitor therapy compared with H2RA therapy may be the result of the differences in the mechanism of action (H2RAs do not block mealstimulated acid secretion) as well as the potential for the development of tolerance of H2RAs. 11,15,16 Clinical studies have demonstrated that proton pump inhibitors are more effective than H2RAs in the treatment of severe reflux disease. 10 However, most patients with GERD have milder nonerosive forms of the disease.…”

Long-Term Proton Pump Inhibitor Use in Children: A Retrospective Review of Safety

“…Proton pump inhibitors (PPIs) are the most effective pharmacologic agents available for the treatment of children as well as adults with GER and GERD [9][10][11][12][13][14], with these agents being considered the mainstay of acid-related treatment [15]. Pediatric patients with GERD often have symptomatic relapse whenever attempts are made to discontinue treatment and this affects their lifestyle [16].…”

Decisions in diagnosing and managing chronic gastroesophageal reflux disease in children

“…Several openlabel treatment studies have found even higher rates of healing of erosive esophagitis in children compared with studies in adults. 41,45,47,50,53 Experience indicates that the most common error in PPI prescribing in children is underdosing. In fact, if the diagnosis in a child is GERD, and there is poor response to PPI, the likely problem is either that an insufficient dose has been used or that the patient is not taking the medication.…”