Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders

Zou, Yanfeng; Wang, Fang; Feng, Xiao-Liang; Li, Wenfei; Tao, Jin‐Hui; Pan, Faming; Huang, Fen; Su, Hong

doi:10.1016/j.neulet.2010.08.019

Cited by 54 publications

(37 citation statements)

References 65 publications

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“…Our data are consistent with those of a meta-analysis performed on patients with mood disorders, in which it was demonstrated that treatment response is associated with FKBP5 gene polymorphism rs4713916, but not with rs3800373 or rs1360780. 31 Similarly, Hawkins et al 32 demonstrated lack of association between rs3800373 and GC response in asthmatic subjects.…”

Section: Discussionmentioning

confidence: 98%

Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms

et al. 2011

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The aim of this study is to investigate the role of single-nucleotide polymorphisms (SNPs) of the glucocorticoid receptor (GR) and of the related co-chaperone FKBP5 genes in the development of glucocorticoid (GC) resistance in Crohn's disease (CD) and ulcerative colitis (UC) patients. We have developed a high-resolution DNA melting method that allows simultaneous identification of GR (BclI, N363S and ER22/23EK) and FKBP5 (rs3800373, rs1360780 and rs4713916) polymorphisms. Genotype frequencies were determined in 100 consecutive CD and 100 UC patients under GCs therapy (50 responders and 50 resisters). The variation of FKBP5 polymorphism rs4713916 (G/A), in the putative promoter region of FKBP5, is significantly associated with resistance to GC treatment in CD (responder ¼ 17% versus resister ¼ 35%; P ¼ 0.0043). No significant differences were found in UC patients. If these preliminary findings will be confirmed, the combination of GR and FKBP5 mutational analyses could help to identify subgroups of CD patients with higher chances to benefit from GC treatment.

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Section: Discussionmentioning

confidence: 98%

Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms

et al. 2011

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“…The sensitivity of the GR to cortisol is further influenced by the FK506-binding protein 5 (FKBP5), which acts as co-chaperone of GR. FKBP5 SNPs (eg, rs1360780) have been associated with insufficient recovery of cortisol levels after psychosocial stress (Ising et al, 2008), with depression (Lekman et al, 2008;Zobel et al, 2010), and with the response to antidepressant treatment (Binder, 2009;Zou et al, 2010). Hence, these SNPs are attractive candidates to moderate the effect of prenatal maternal psychopathology on child development.…”

Section: Introductionmentioning

confidence: 99%

Variation in the Glucocorticoid Receptor Gene at rs41423247 Moderates the Effect of Prenatal Maternal Psychological Symptoms on Child Cortisol Reactivity and Behavior

Velders

Dieleman

Cents

et al. 2012

Neuropsychopharmacol

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Prenatal maternal psychopathology affects child development, but some children seem more vulnerable than others. Genetic variance in hypothalamic-pituitary-adrenal axis genes may influence the effect of prenatal maternal psychological symptoms on child emotional and behavioral problems. This hypothesis was tested in the Generation R Study, a population-based cohort from fetal life onward. In total, 1727 children of Northern European descent and their mothers participated in this study and were genotyped for variants in the glucocorticoid receptor (GR) gene (rs6189/rs6190, rs10052957, rs41423247, rs6195, and rs6198) and the FK506-binding protein 5 (FKBP5) gene (rs1360780). Prenatal maternal psychological symptoms were assessed at 20 weeks pregnancy and child behavior was assessed by both parents at 3 years. In a subsample of 331 children, data about cortisol reactivity were available. Based on power calculations, only those genetic variants with sufficient minor allele frequencies (rs41423247, rs10052957, and rs1360780) were included in the interaction analyses. We found that variation in GR at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child emotional and behavioral problems (beta 0.41, SE 0.16, p ¼ 0.009). This prenatal interaction effect was independent of mother's genotype and maternal postnatal psychopathology, and not found for prenatal psychological symptoms of the father. Moreover, the interaction between rs41423247 and prenatal psychological symptoms was also associated with decreased child cortisol reactivity (beta À2.30, p-value 0.05). These findings emphasize the potential effect of prenatal gene-environment interaction, and give insight in possible mechanisms accounting for children's individual vulnerability to develop emotional and behavioral problems.

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“…Condiciones que proveen a diario estrés moderado pero crónico, que ya ha sido identificadas como depresógenas por un grupo extenso de autores (Almeida et al, 2011;Sterner y Kalynchu, 2010;Vargas-Navarrio, Latorre-López y Parra-Cárdenas, 2011;Zou et al, 2012), ya que aumentan la reactividad, deterioran la capacidad real de respuesta y afectan la evaluación que la persona hace acerca de su capacidad.…”

Section: Discussionunclassified

“…Estar expuesto a un alto número de estresores que ocurren de forma consecutiva (con un impacto psicológico moderado), no contar con adecuado soporte familiar y estar expuesto a un ambiente familiar disfuncional, incrementan el riesgo de padecer de depresión y que esta se haga más severa, como lo muestran hallazgos similares de estudios previos realizados por Folkman (2001). Más que el impacto psicológico de un evento estresante en particular, es la acumulación de eventos de impacto psicológico moderado lo que se asocia a la aparición y agudización de la depresión en hombres (Bogdan et al, 2013;Sterner y Kalynchu, 2010;Zou et al, 2012).…”

Section: Discussionunclassified

Prevalencia de depresión y factores asociados en hombres.

Pérez

Rodríguez

2016

Acta. Colomb. Psicol.

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ResumenEl objetivo del presente estudio fue evaluar la prevalencia de depresión, detectar el riesgo suicida e identificar los factores sociodemográficos y personales asociados a este trastorno. La muestra no aleatorizada estuvo conformada por 1525 hombres colombianos con edades entre 18 y 83 años procedentes de 22 departamentos y de distintos niveles educativos. Para evaluar la depresión se usó el Cuestionario de Depresión para Hombres (Álvarez y Londoño, 2012); para evaluar la comorbilidad con ansiedad se usó la Escala de Ansiedad HADS (Zigmond y Snaith, 1983) y el IMAFE (Lara, 1991); y para recolectar información acerca de los factores personales y sociodemográficos se usó una ficha de registro. Se analizaron los datos para calcular la prevalencia de corte, el riesgo suicida, la comorbilidad a través del uso del paquete estadístico SPSS. Se concluye que la prevalencia real reportada y el riesgo suicida en la población estudiada son más altos que los detectados usando un instrumento no sensible al género. Palabras clave: Depresión, hombres, riesgo suicida, prevalencia. PREVALENCE OF DEPRESSION AND ASSOCIATED FACTORS IN MEN AbstractThis epidemiologic study aimed to evaluate the prevalence of depression, the suicide risk and the demographic and personal factors associated with depression severity in men. The non-randomized sample of participants was formed by 1525 Colombian men aged 18 to 83 years old, from 22 departments and different educational levels. The instruments used to evaluate the above factors were the Men's Depression Questionnaire (Alvarez and Londoño, 2012), the Anxiety Scale HADS (Zigmond y Snaith, 1983) and the IMAFE (Lara 1991), and in order to collect data about personal and socio-demographic factors, a registration card was used. Data were analyzed to calculate the prevalence, suicide risk and comorbidity with anxiety through the use of SPSS. It was concluded that the prevalence of depression and suicide risk in the population object of study is higher than the one identified in previous studies when a non-gender sensitive questionnaire was used. Keys words: Depression, men, suicide risk, prevalence. PREVALÊNCIA DE DEPRESSÃO E FATORES ASSOCIADOS EM HOMENSResumo O objetivo deste estudo foi avaliar a prevalência de depressão, detectar o risco suicida e identificar os fatores sociodemográficos e pessoais associados com esse transtorno. A amostra não aleatorizada foi conformada por 1525 homens colombianos com idade entre 18 e 83 anos, procedentes de 22 estados e de diferentes níveis de escolaridade. Para avaliar a depressão, foi utilizado o Teste de Depressão para Homens (Álvarez e Londoño, 2012); para avaliar a comorbilidade com ansiedade, usou-se a Escala Hospitalar de Ansiedade e Depressão (Hads -Zigmond e Snaith, 1983) e o Inventário de Masculinidade e Feminilidade (Imafe -Lara, 1991); para coletar informação sobre os fatores pessoais e sociodemográficos, empregou-se um formulário de registro. Analisaram-se os dados para calcular a prevalência de corte, o risco suicida, a comorbilidade por mei...

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Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders

Cited by 54 publications

References 65 publications

Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms

Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms

Variation in the Glucocorticoid Receptor Gene at rs41423247 Moderates the Effect of Prenatal Maternal Psychological Symptoms on Child Cortisol Reactivity and Behavior

Prevalencia de depresión y factores asociados en hombres.

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