2022
DOI: 10.1016/j.tiv.2022.105418
|View full text |Cite
|
Sign up to set email alerts
|

Meta-analysis of in-vitro cytotoxicity evaluation studies of zinc oxide nanoparticles: Paving way for safer innovations

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
9
0

Year Published

2022
2022
2025
2025

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 14 publications
(9 citation statements)
references
References 92 publications
0
9
0
Order By: Relevance
“…A meta-analysis performed in 2022, based on a systematic review of 76 publications, revealed several attributes responsible for cytotoxicity after exposure to ZnO-NPs. Based on the results of in vitro studies, it was established that nanotoxicity strictly depends on the dose and size of NPs, exposure time, and the type of cell line [ 273 ]. Examples of NPs and their effects on reproductive function in males are collected in Table 4 .…”
Section: Male Reproductive Toxicity Due To Metallic Nanoparticlesmentioning
confidence: 99%
“…A meta-analysis performed in 2022, based on a systematic review of 76 publications, revealed several attributes responsible for cytotoxicity after exposure to ZnO-NPs. Based on the results of in vitro studies, it was established that nanotoxicity strictly depends on the dose and size of NPs, exposure time, and the type of cell line [ 273 ]. Examples of NPs and their effects on reproductive function in males are collected in Table 4 .…”
Section: Male Reproductive Toxicity Due To Metallic Nanoparticlesmentioning
confidence: 99%
“…The average industrial production of ZnO NPs is estimated at around 550–33,400 tonnes (Faizan et al, 2020; Rahman et al, 2022). With so many distinct products available, ZnO NPs are regarded as the “next generation solution” (Kad et al, 2022). With various industries involved in the production of ZnO NPs, the focus is on the occupational group which is exposed to these particles on a daily basis.…”
Section: Introductionmentioning
confidence: 99%
“…Nanoparticle (NP) exposure changed the levels of enzymes and molecules involved in oxidative stress [including increased MDA and reduced superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT)] ( 16 ) and inflammation (TNF-α; IL-6; C-reactive protein, CRP) ( 17 ), and cause damages in liver (increased alanine aminotransferase, ALT) ( 18 ), kidney (increased creatinine, urea, uric acid) ( 11 ), heart (increased creatine phosphokinase, CPK) ( 17 ), testes (decreased sperm counts and motility) ( 19 ) and brain (decreased AChE activity) ( 19 ) in murine models compared with controls. In vitro publications showed cell viability was substantially suppressed and cell apoptosis was significantly increased after nanoparticle exposure, which was associated with elevated reactive oxygen species (ROS) ( 20 22 ). These findings suggest attenuation of oxidant stress and inflammation may act as potential strategies for preventing the negative effects of nanomaterials.…”
Section: Introductionmentioning
confidence: 99%