Gallstone disease is one of the common diseases. Laparoscopic cholecystectomy is the routine surgical treatment. However, the optimal timing and safety to perform this operation are still debated, especially in exceptional situations of each patient. In this chapter, we have collected data from many literatures to summarize the role of laparoscopic cholecystectomy in special situations that are in patients with pregnancy, cirrhosis, diagnosis of acute cholecystitis, and situs inversus.