Aims and Objectives: This study focused on the predictive effects of physical inactivity, body shape, and tobacco use on heart disease patients. Background: Heart disease is a condition that can be prevented with healthy lifestyle choices such as physical exercise, proper nutrition, and avoiding tobacco use. Design: The current study used a correlational cross-sectional survey design. Methods: Primary healthcare centers were selected randomly from the all practices in the middle region in Jordan. Patients were included if they had a working diagnosis of heart disease which was documented in their case notes, aged 18 years and older, visited out-patient department within the community hospitals or whom attended primary healthcare centers. Results: Factors associated with heart disease, as identified in the univariate regression analysis, were tobacco use, body shape, and employment status. Furthermore, Odds Ratio for patients with heart disease and tobacco was calculated and found that patients who smoked tobacco are more likely to have heart disease compared to non-smokers. Conclusion: The study findings suggest that the behavioural modification should be given top priority to prevent heart disease form occurring. On the other hand, regular physical activity may be useful to prevent the development of heart disease.