Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues

Zhang, Qinghe; Sun, Hao; Zheng, Ruizhi; Li, Yingchun; Zhang, Qian; Cheng, Pan; Tang, Zhichen; Huang, Fen

doi:10.1016/j.gene.2013.06.006

Cited by 104 publications

(68 citation statements)

References 54 publications

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“…MiRNAs are included among these regulatory passwords (18). As important factors regulated by gene transcription, miRNAs participate widely in important life processes, including cell proliferation, differentiation, apoptosis and development (18). In the present study, the DFS and OS for patients with colorectal cancer with increased miR183 expression were decreased compared with that of the DFS and OS for patients with colorectal cancer with decreased miR183 expression.…”

Section: Discussionmentioning

confidence: 52%

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Wnt/catenin β1/microRNA 183 predicts recurrence and prognosis of patients with colorectal cancer

Chen

2018

Oncol Lett

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Abstract. The present study assessed the association between the Wnt/catenin β1 (CTNNB1)/microRNA (miR)183 signaling pathway and the recurrence and prognosis of colorectal cancer. The expression of Wnt, CTNNB1 and miR183 in primary colorectal cancer tissue was increased compared with that in the paracarcinoma tissue. Disease-free survival and overall survival were decreased in patients with colorectal cancer and increased miR183 expression compared with those in patients with colorectal cancer and decreased miR183 expression. The human colorectal cancer cell line HCT-116 was treated with 5 µM inhibitor of Wnt response (IWR-2) for 24 h to inhibit Wnt protein expression. Downregulating Wnt and CTNNB1 expression inhibited the viability of, and induced cell death and caspase 3 protein expression in, HCT-116 cells. The expression of BCL2 associated X protein and miR183 was increased, and cyclin D1 protein expression was suppressed, by the downregulation of Wnt and CTNNB1 expression in HCT-116 cells. Collectively, the results of the present study suggested that the Wnt/CTNNB1/miR183 signaling pathway may represent a promising biomarker for the recurrence and prognosis of colorectal cancer.

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Section: Discussionmentioning

confidence: 52%

“…Alteration of these codes is an important means of regulating gene expression. MiRNAs are included among these regulatory passwords (18). As important factors regulated by gene transcription, miRNAs participate widely in important life processes, including cell proliferation, differentiation, apoptosis and development (18).…”

Section: Discussionmentioning

confidence: 99%

Wnt/catenin β1/microRNA 183 predicts recurrence and prognosis of patients with colorectal cancer

Chen

2018

Oncol Lett

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“…11,12 According to previous reports, members of the miRNA-183 family are highly expressed in CRC tissues compared with normal colorectal tissues, and miR-183 is the most highly up-regulated member of this family. [13][14][15][16] Additionally, a previous study showed that overexpression of miR-183 in tumors was significantly correlated with advanced clinical stage, lymph node and distant metastases, and poor prognosis of CRC. 17 Therefore, we hypothesized that the expression levels of miR-183 in the plasma could be useful clinical biomarkers in CRC patients.…”

Section: Introductionmentioning

confidence: 99%

Plasma miR-183 predicts recurrence and prognosis in patients with colorectal cancer

Yuan

Zhu

et al. 2015

Cancer Biology & Therapy

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Colorectal cancer (CRC) is one of the most common malignancies worldwide. The prognosis for this cancer is poor, and the development of novel biomarkers, particularly non-invasive surrogate biomarkers, is urgently needed. Recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the blood and can serve as useful biomarkers for various types of cancer. In this study, the miR-183 expression levels were found to be significantly overexpressed in plasma samples from CRC patients compared with controls, and the postoperative plasma miR-183 levels were significantly reduced compared with the preoperative levels. The value of the area under the receiver operating characteristic (ROC) curve obtained for miR-183 was 0.829, which was higher than those for carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). High plasma miR-183 expression was significantly associated with lymph node metastasis, distant metastasis, higher pTNM stage (III-IV), and tumor recurrence. CRC patients with elevated miR-183 expression in plasma displayed shorter disease-free survival (DFS) and lower overall survival (OS). More importantly, plasma miR-183 was independently correlated with tumor recurrence and a lower OS. Collectively, our results suggested that the elevated miR-183 in the plasma could be a promising biomarker for predicting the risk of tumor recurrence and poor survival in CRC patients.

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“…Apoptosis and angiogenesis are major mechanisms involved in the pathogenesis of PE (20,21). Functional analysis indicated that miR-183 was involved in cell differentiation, apoptosis and cell invasion in various types of cancer (22). The study by Shi et al (23) revealed a promotional role of miR-183 in endometrial stromal cells and inhibition of miR-183 on cell invasive ability.…”

Section: Discussionmentioning

confidence: 99%

Quantification of preeclampsia-related microRNAs in maternal serum

Long

Jiang

et al. 2015

Biomedical Reports

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Abstract. To identify the specific serum preeclampsia (PE)-related biomarkers, 10 microRNAs (miRNAs) were selected based on their reported aberrant (4 upregulated and 6 downregulated) expression in PE placenta. A total of 1,035 pregnant patients were enrolled. Finally, 32 pregnancies with PE and 32 healthy pregnancies were incorporated in the study. The expression of these 10 miRNAs in the different trimesters was determined by SYBR-Green reverse transcription-quantitative polymerase chain reaction. Compared with that in the healthy controls, the expression levels of miR-152, miR-183 and miR-210 in PE serum were higher in the second and third trimester, whereas the expression of miR-182 was only higher in the third trimester. The expression levels of 6 miRNAs (miR-1, miR-328, miR-363, miR-377, miR-500 and miR-584) that were downregulated in PE placenta showed no significant differences between pregnancies complicated by PE and healthy pregnancies throughout the 3 trimesters. Areas under the receiver operating characteristic [standard error (SE)] during the 20-24th gestational week for predicting PE were 0.026), 0.031) and miR-210: 0.93 (SE, 0.018). In conclusion, the expression levels of serum miR-152, miR-183 and miR-210 were elevated since the second trimester in pregnancies complicated with PE, indicating their potentials as serum biomarkers for forecasting PE.

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Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues

Cited by 104 publications

References 54 publications

Wnt/catenin β1/microRNA 183 predicts recurrence and prognosis of patients with colorectal cancer

Wnt/catenin β1/microRNA 183 predicts recurrence and prognosis of patients with colorectal cancer

Plasma miR-183 predicts recurrence and prognosis in patients with colorectal cancer

Quantification of preeclampsia-related microRNAs in maternal serum

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