Meta-analysis of Paternal Age and Schizophrenia Risk in Male Versus Female Offspring

Miller, Brian J.; Messias, Erick; Miettunen, Jouko; Alaräisänen, Antti; Jarvelin, M. R.; Koponen, Hannu; Räsänen, Pirkko; Isohanni, Matti; Kirkpatrick, Brian

doi:10.1093/schbul/sbq011

Cited by 179 publications

(125 citation statements)

References 47 publications

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“…Actually, a study by Malaspina and peers has shown that with each progressing decade of paternal age the risk of schizophrenia almost doubled and by the age of 45 the risk values were tripled in relation to the ones found for younger males [113]. These results were in accordance to several others that likewise confirmed the detrimental effect of APA on schizophrenia risk for the offspring [114]. An additional mental illness linked to APA is the bipolar disorder.…”

Section: Advanced Paternal Age and Offspring Health Complicationssupporting

confidence: 76%

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Rabaça¹,

Ferreira²

2016

Andrology(Los Angel)

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The rise in life expectancy and the desire to establish a stable career prior to parenthood leads couples to a delayed childbearing. Advanced parental age at the time of pregnancy portrays several risks, with the majority of couples above 35 experiencing reproductive impairments. While the effect of women's age on fertility is well known, the influence of paternal age is less understood. Thus, efforts have been made to comprehend the influence of APA on pregnancy upkeep and disease risk for the offspring. Over the last decades numerous studies aimed to establish the relationship between APA and male fertility potential. It has been found that APA is related to testicular and hormonal alterations, along with a decreased sperm production, quality and DNA integrity. As expected, these alterations compromise the reproductive potential of older men and have been associated with several fecundity problems, including increased time to pregnancy and abortion rates, and decreased fertilization and pregnancy rates. Additionally, alterations in offspring health, like genetic disorders, mental illnesses, congenital anomalies and cancer, have also been linked to APA. As a result, APA influence on the reproductive outcome must be taken into consideration when counseling couples attending family planning consultations or pursuing fertility treatments. Nonetheless, to date, there are still no definite results regarding this problem and an age threshold has yet not been established and additional research to better elucidate the effects of APA on fertility and offspring's health is needed. Likewise, establishing an age threshold for APA would be of great value to males thinking of delaying parenthood, and to physicians for medical advice purposes.

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Section: Advanced Paternal Age and Offspring Health Complicationssupporting

confidence: 76%

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Rabaça¹,

Ferreira²

2016

Andrology(Los Angel)

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“…Several studies have reported higher incidence of neurodevelopmental IVF in vitro fertilization, IVF-ET in vitro fertilization and embryo transfer, GIFT gamete intrafallopian transfer, CI conventional insemination, ICSI intracytoplasmic sperm injection disorders in children with older fathers. Similarly, Miller et al reported a significant association between advanced paternal age and schizophrenia among the offspring by meta-analysis [123]. Advanced paternal age is a risk factor for development of bipolar disorder in children and the highest risk has been reported for children whose fathers were equal and above 55 years old [123].…”

Section: Dna Mutations and Paternal Agingmentioning

confidence: 97%

“…Similarly, Miller et al reported a significant association between advanced paternal age and schizophrenia among the offspring by meta-analysis [123]. Advanced paternal age is a risk factor for development of bipolar disorder in children and the highest risk has been reported for children whose fathers were equal and above 55 years old [123].…”

Section: Dna Mutations and Paternal Agingmentioning

confidence: 97%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

195

118

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The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitarygonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

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“…They have found that advanced paternal age was associated with schizophrenia, and the results were independent from sociodemographic or socioeconomic parameters, family history or early parental death. Meta-analysis of paternal age and schizophrenia risk in male vs. female offspring made by Miller et al 90 revealed that relative risk in the oldest fathers (o50 years) was 1.66 compared with younger fathers. The population attributable risk percentage was 10% for paternal age of .30 years and 5% for paternal age of ,25 years.…”

Section: Schizophreniamentioning

confidence: 99%

Advanced paternal age and reproductive outcome

Wiener-Megnazi¹,

Auslender²,

Dirnfeld³

2011

Asian J Androl

102

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Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.

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Meta-analysis of Paternal Age and Schizophrenia Risk in Male Versus Female Offspring

Cited by 179 publications

References 47 publications

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Effects of aging on the male reproductive system

Advanced paternal age and reproductive outcome

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