Meta-analysis of probiotics and/or prebiotics for the prevention of eczema

Abstract

This meta-analysis found that probiotics or synbiotics may reduce the incidence of eczema in infants aged <2 years. Systemic sensitization did not change following probiotic administration.

Differential modification of genetic susceptibility to childhood eczema by two probiotics

“…Clinical trials have shown a wide range of beneficial effects of probiotics. Other probiotic intervention studies have also found at least a partial reduction in eczema [33,34] while others have found probiotics to have no effect [35][36][37][38]. Recent studies have also shown a beneficial effect of probiotics in the prevention of eczema.…”

Prebiotics and Probiotics

“…Nutrients 2017, 9,191 Phagocytic capacity outcomes were consistent among individual studies (SMD range: 0.60 to 1.01). Furthermore, each study reported statistically significant improvements in PMN phagocytic capacity with B. lactis HN019 relative to control.…”

“…Moreover, synbiotics are used in the treatment of hepatic conditions [189] and improve the absorption of calcium, magnesium, and phosphorus [190]. Danq et al (2013), in a meta-analysis, evaluated published studies on pro/prebiotics for eczema prevention, investigating bacterial strain efficacy and changes to the allergy status of the children involved. This meta-analysis found that probiotics or synbiotics may reduce the incidence of eczema in infants aged <2 years.…”

Probiotics in Disease Prevention and Treatment

“…With the exception of atopic dermatitis, data from meta‐analyses have revealed insufficient evidence for probiotics in preventing the development of asthma, allergic rhinitis, or food allergy . With regard to preventing or reducing the severity of atopic dermatitis, there is evidence suggesting a benefit of probiotics, but this effect is variable and not consistent between studies . In one recent meta‐analysis examining 17 studies, results showed that when mothers were treated along with their infants with a probiotic, the infant had a significant reduction in RR for developing eczema compared to controls (RR, 0.78 [95%CI, 0.69‐0.89]; P < 0.001), particularly those supplemented with a mixture of probiotics (RR, 0.54 [95%CI, 0.43‐0.68]; P < 0.001) …”