Meta-Analysis of Progestin and Estrogen Receptors in Human Meningiomas

Gabos, Stephen; Berkel, J

doi:10.1159/000110938

Cited by 26 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The HR of brain tumor development was higher in the female patients with PD than in the male patients with PD (2.65 and 1.71, respectively). An observed increase in the prevalence of meningioma in women has been attributed to the hormone effect . Expressions of various hormone receptors, such as those of progesterone and estrogen receptors, are detected in meningioma .…”

Section: Discussionmentioning

confidence: 99%

Increased risk of brain tumor in patients with Parkinson's disease: a nationwide cohort study in Taiwan

Tang

Muo

et al. 2015

Acta Neurol Scand

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Increased risk of brain tumor in patients with Parkinson's disease: a nationwide cohort study in Taiwan

Tang

Muo

et al. 2015

Acta Neurol Scand

View full text Add to dashboard Cite

show abstract

“…However, due to the variability of this reaction between different laboratories, an increased MIB-1 index does not qualify as a single diagnostic criterion for a WHO grade II. Atypical or anaplastic meningiomas more frequently lack progesterone receptors [17]. Progesterone receptor-negative meningiomas tend to be larger than progesterone receptor-positive meningiomas [6,27].…”

Section: Meningiomasmentioning

confidence: 97%

New developments in the pathology of skull base tumors

et al. 2001

View full text Add to dashboard Cite

As an anatomical interface between various tissues, the skull base harbors an exceptionally broad variety of neoplasms, some of which pose a major challenge for surgical pathology. The characterization of distinct immunohistochemical expression profiles and the identification of molecular genetic alterations associated with different tumor entities have significantly advanced this field. The new World Health Organization (WHO) classification of tumors of the nervous system lists 15 histopathological variants of meningioma. Of clinical importance are those entities that carry an increased risk of recurrence and a poor prognosis, i.e., the atypical meningioma (WHO grade II), clear-cell meningioma (WHO grade II), chordoid meningioma (WHO grade II), rhabdoid meningioma (WHO grade III), papillary meningioma (WHO grade III), and anaplastic meningioma (WHO grade III). Diagnostic criteria for atypical and anaplastic meningioma variants have now been stringently defined. The differential diagnosis of meningiomas includes hemangiopericytoma, hemangioblastoma, solitary fibrous tumor, sarcomas, and chordoid neoplasms. Recent data highlight the importance of distinguishing chordoma and chondrosarcoma of the skull base since chondrosarcomas show a significantly better clinical outcome. Among the less common, aggressive tumor entities in this anatomical region, infiltrating pituitary adenoma/pituitary carcinoma, superficial malignant gliomas, rhabdomyosarcoma, olfactory neuroblastoma, various sarcomas, and malignant lymphoma must be considered. Profiles of molecular genetic alterations have been established for several of these neoplasms and may facilitate the differential diagnosis. This review summarizes recent developments in the histopathological characterization, classification, and molecular pathology of neoplasms arising at the skull base.

show abstract

“…The exact role of progesterone is far from being fully elucidated despite the numerous published research paper on this topic. Surely, the majority of meningiomas express PR, which can be detected also by immunohistochemistry [26]. The fact that tumour growth is usually occurring in the luteal phase of menstrual cycle or in the second or third trimester of pregnancy, when progesterone plasma concentration is higher, suggests the role of sex hormones in the mechanism [27].…”

Section: Pathophysiological and Morphological Aspectsmentioning

confidence: 99%

Pathophysiology of meningioma growth in pregnancy

et al. 2017

View full text Add to dashboard Cite

AbstractMeningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanation is rooted in the complex physiological changes and hormonal differences during pregnancy. The increased meningioma growth observed in pregnancy is presumably the result of endocrine mechanisms. These include increase in progesterone, human placental lactogen (hPL) and prolactin (PRL) serum levels. In contrast, levels of pituitary hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic gonadotropin (hCG) produced by the placenta are decreasing in the mother prior to childbirth. Besides, vascular factors also play a crucial role. Peritumoral brain edema (PTBE), with well-known causative association with vascular endothelial growth factor (VEGF), can often be seen both with imaging and in the surgical specimens. Our aim is to assess published research on this topic including diagnostic and therapeutic guidelines, and to provide a clinically useful overview on the pathophysiology and biological behaviour of this rare complication of pregnancy.

show abstract

Meta-Analysis of Progestin and Estrogen Receptors in Human Meningiomas

Cited by 26 publications

References 9 publications

Increased risk of brain tumor in patients with Parkinson's disease: a nationwide cohort study in Taiwan

Increased risk of brain tumor in patients with Parkinson's disease: a nationwide cohort study in Taiwan

New developments in the pathology of skull base tumors

Pathophysiology of meningioma growth in pregnancy

Contact Info

Product

Resources

About