Meta-analysis of Studies of Alcohol and Breast Cancer with Consideration of the Methodological Issues

Key, Jane; Hodgson, Susan; Omar, Rumana; Jensen, Tina Kold; Thompson, Simon G.; Boobis, Alan R.; Davies, Donald S.; Elliott, Paul

doi:10.1007/s10552-006-0011-0

Cited by 205 publications

(155 citation statements)

References 30 publications

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“…When the dose-response effect was measured an increased risk of 10% for each 10 g of ethanol/ day (RR 1.10, 95%CI 1.05-1.15) was observed. The risk remained regardless of the type of beverage consumed (beer, wine or spirits) (Key et al, 2006). Another study, after adjustment for smoking, showed a dose-response effect with a 7% increase in the risk of developing breast cancer for each 10g/day of alcohol consumed (p<0.001) (Hamajima et al, 2002).…”

Section: Alcohol Consumption and Risk Of Breast And Female Genital Ormentioning

confidence: 97%

“…Four publications were found (Table 3) evaluating the association between alcohol consumption and the risk of breast cancer (Hamajima et al, 2002;Key et al, 2006;Bagnardi et al, 2012;Seitz et al, 2012). A meta-analysis classified the articles in scores according to the degree of control for confounding.…”

Section: Alcohol Consumption and Risk Of Breast And Female Genital Ormentioning

confidence: 99%

“…Initially 14 articles were selected (Hamajima et al, 2002;Key et al, 2006;Moskal et al, 2007;Fillmore et al, 2009;Friberg et al, 2010;Islami et al, 2010;Mao et al, 2010;Uehara and Kiyohara, 2010;Bagnardi et al, 2011;Ferdiko et al, 2011;Sun et al, 2011;Tramacere et al, 2012). No publications were found regarding thyroid cancer.…”

Section: Introductionmentioning

confidence: 99%

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Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

Menezes¹,

Bergmann²,

Thuler³

2013

Asian Pacific Journal of Cancer Prevention

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This study aimed to discuss the consumption of alcohol as a risk factor for major cancers. We performed a search in the PubMed database, using the following inclusion criteria: meta-analysis published in English in the last 10 years that addressed the relationship between alcohol and the risk of developing cancer. The results indicate that moderate to heavy consumption of alcohol increases the risk of developing cancer of the oral cavity and pharynx, esophagus, stomach, larynx, colorectum, central nervous system, pancreas, breast and prostate. This review did not find any association between alcohol consumption and an increased risk of cancers of the lung, bladder, endometrium and ovary. It was also observed that alcohol consumption may be inversely related to thyroid cancer. Our systematic review has confirmed consumption of alcohol as a risk factor for the development of several types of cancer. Research (2007) report that there is convincing evidence linking the consumption of alcoholic beverages to cancers of the mouth, pharynx, larynx, esophagus, breast and bowel, the latter being only in men. In addition, there is a likely relationship between the consumption of alcoholic beverages and an increased risk of colon cancer and liver cancer in women.The preparation of this systemic review study is based on these considerations, with the aim of discussing the association between alcohol consumption and the main types of cancer. The expected contribution is the disclosure of consolidated information about this possible risk ratio, contributing to the establishment of strategies to prevent the occurrence of cancer. Materials and MethodsWe performed a systematic literature review of metaanalysis that was conducted to evaluate the association between alcohol consumption and cancer.The publications were identified in the PubMed bibliographic database, and used the following keywords: cancer, alcohol and meta-analysis. The first two were used as words that appeared on the title and the latter as the type of study chosen. We chose to establish a period of 10 years Raquel Ferreira de Menezes et al

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Section: Alcohol Consumption and Risk Of Breast And Female Genital Ormentioning

confidence: 97%

Section: Alcohol Consumption and Risk Of Breast And Female Genital Ormentioning

confidence: 99%

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Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

Menezes¹,

Bergmann²,

Thuler³

2013

Asian Pacific Journal of Cancer Prevention

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“…1,2 Over the years, numerous epidemiological studies have shown that increased alcohol consumption and binge-drinking are dose-dependently associated with the development of human breast cancers. [3][4][5][6][7][8][9] These findings have also been recapitulated using mouse animal models, where ethanol-fed mice showed increased rates of breast cancer tumor growth. 10 Importantly, alcohol consumption also significantly…”

Section: Introductionmentioning

confidence: 92%

Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism

et al. 2013

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“…Epidemiological studies conducted mainly in Western countries have shown that alcohol consumption is associated with an increased risk of breast cancer (Hamajima et al 2002;Key et al 2006), and it is now regarded as an established breast cancer risk factor (Baan et al 2007). Among the Japanese population, however, a qualitative review of the existing evidence has indicated that the association between alcohol consumption and breast cancer risk remains inconclusive (Nagata et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Alcohol Consumption and Breast Cancer Risk According to Hormone Receptor Status in Japanese Women: A Case-Control Study

Takizawa

Kawai

Kakugawa

et al. 2018

Tohoku J. Exp. Med.

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Alcohol consumption is a risk factor for breast cancer in Western countries, but few studies have evaluated the risk for Japanese women, who have a relatively low alcohol intake. This case-control study investigated the association of alcohol consumption with breast cancer risk according to estrogen-receptor and progesterone-receptor (ER/PgR) status in Japanese women. From female patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2011, 1,256 breast cancer cases (669 ER+/ PgR+, 162 ER+/PgR−, 21 ER−/PgR+, 305 ER−/PgR−, and 99 missing) and 2,933 controls were selected. Alcohol-related measures were assessed using a self-administered questionnaire. Unconditional logistic regression analysis was performed. Alcohol-related measures were not associated with breast cancer risk among the women overall. Moreover, no association was observed between ever drinking and the risk of a concordant receptor subtype (ER+/PgR+ or ER−/PgR−). Conversely, ever drinking was inversely associated with the risk of discordant subtype (ER+/PgR−, odds ratio (OR) = 0.63, 95% confidence interval (CI): 0.41-0.95; ER−/PgR+, OR = 0.44, 95% CI: 0.14-1.42). For ER+/PgR−, an inverse association with the amount of alcohol consumed per day was observed (P for trend = 0.04), and this inverse association was limited to premenopausal women. Alcohol consumption may have differential effects on concordant and discordant receptor subtypes of breast cancer. In view of the low frequency of discordant subtype in Japanese women and their relatively low alcohol intake, our findings may provide a clue for elucidating the etiology of breast cancer rather than for preventing discordant subtype.

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Meta-analysis of Studies of Alcohol and Breast Cancer with Consideration of the Methodological Issues

Cited by 205 publications

References 30 publications

Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism

Alcohol Consumption and Breast Cancer Risk According to Hormone Receptor Status in Japanese Women: A Case-Control Study

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