Meta‐analysis of survival based on resection margin status following surgery for recurrent rectal cancer

Abstract

Patients undergoing R0 resection have the greatest survival advantage following surgery for recurrent rectal cancer. There is a survival advantage for R1 over R2 resection, but there may be no benefit of R2 resection over palliative treatment.

240. Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: A single centre retrospective study

“…In our study the survival time of patients after R0 resection was longer in comparison to non-radical resection group. This finding is in agreement with the results of meta-analysis by Bhangu et al who found no survival benefit of macroscopically non-radical (R2) resection over non-resection (laparotomy) [21].…”

“…Radical (R0) resection of LR is associated with at least twice higher survival than in non-radical (R1/R2) resection and remains the treatment of choice [21,22]. The tumor-free resection margin is a favorable prognostic factor for improved local control and overall survival [19][20][21][23][24][25][26].…”

“…Postoperative complications vary from 15% to 68% [38]. The percentage of serious postoperative complications ranges from 27% to 81% [20,21,28,35]. The most common complication after IO(E)RT is small bowel obstruction (14%) and pelvic abscesses (12%) [17,20].…”

Treatment of Locally Recurrent Rectal Carcinoma in Previously (Chemo)Irradiated Patients

“…24 also, several studies have shown that complete surgical resections provide a significant survival advantage compared with incomplete resections. [11][12][13]15,17,19,21,[26][27][28][29][30][31][32] in the included studies, most recurrences were treated with chemoradiation instead of radiotherapy alone. in patients with PRC, chemoradiation results in better lC than radiotherapy alone, without a positive effect on os.…”

Is stereotactic body radiotherapy a treatment option for pelvic recurrences?

“…Hastaların sadece %20-30'unda R0 rezeksiyonlar başarılabilir. [6] Diğer taraftan %68 gibi yük-sek oranlara ulaşan ameliyat sonrası komplikasyon oranları bildirilmiştir. [7][8][9][10][11][12] Kemoterapi (KT) ve eksternal radyoterapi (EBRT) sadece palyatif fayda sağlamaktadır.…”