Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

Deng, Peng; Wu, Junchao

doi:10.17235/reed.2016.4176/2015

Cited by 20 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We identified 20 risk and 14 protective factors for CD, as well as 16 risk and 14 protective factors for UC. As shown in Tables 1 and 2 and Figures 2 and 3, factors (6 risk and 5 protective factors for CD, 3 risk and 5 protective factors for UC) that had common effects on both the populations were mostly in accordance with previous results 2,30‐35 . Furthermore, there were several factors associated with CD or UC either for Western or Eastern populations only, not for the whole population, suggesting that geographical and ethnic variations may have influenced IBD development.…”

Section: Discussionsupporting

confidence: 88%

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Zhao

Feng

Ben‐Horin

et al. 2021

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary Background While the incidence of inflammatory bowel disease (IBD) has stabilised in the West, it is still increasing in several newly industrialised countries. Aims To investigate whether the environmental and dietary risk factors for IBD differ between Eastern and Western populations Methods We systematically searched PubMed, Embase, and Web of Science for studies published from inception through June 30, 2020. Data were pooled using a random effects model. Results Overall, 255 studies were assessed. We identified 25 risk factors for IBD, seven of which were noted in both Eastern and Western populations: family history of Crohn's disease [CD] or ulcerative colitis [UC], former smoking (CD/UC), smoking (CD), appendicectomy (CD), tonsillectomy (CD), meat and meat products (CD), and vitamin D deficiency (UC). The remaining factors, including urban living, current smoking, antibiotics, oral contraceptives, caesarean section, isotretinoin, total energy, fat, cholesterol, fatty acids and their sub‐classifications, eggs, and soft drinks, were associated with an increased risk of IBD in Western or Eastern populations only. We identified 21 protective factors for IBD, among which eight were common in the East and West: farm animals (CD/UC), Helicobacter pylori infection (CD/UC), multiple births (CD), physical activity (CD), history of breastfeeding (CD), pets (UC), current smoking (UC), and coffee intake (UC). Ten factors conferred protection against IBD in Western populations only, whereas eight factors conferred protection against IBD in Eastern populations only. Conclusions Numerous environmental and dietary factors influenced the development of IBD in both Western and Eastern populations, whereas certain factors influenced IBD risk differently in these populations.

show abstract

Section: Discussionsupporting

confidence: 88%

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Zhao

Feng

Ben‐Horin

et al. 2021

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…b) Figure 3. The impact of appendectomy on the rate of Ulcerative colitis In the present review, appendectomy was lower among patients with ulcerative colitis in agreement with a previous study that included nineteen studies assessing both the risk of developing ulcerative colitis and the time course of the disease in addition to appendiceal orifice inflammation (Deng & Wu, 2016). The current analysis assessed both ulcerative colitis and Crohn's disease.…”

Section: Resultssupporting

confidence: 88%

Appendectomy Impact on Inflammatory Bowel Diseases: A Meta-Analysis

Alghamdi¹,

Alhazmi²

2021

World J Environ Biosci

View full text Add to dashboard Cite

The observed higher rate of appendectomy despite the success of the conservative (non-surgical) approach might be due to the lack of awareness. The cecal appendix is not merely rudimentary because of its role on the gut microbiota and the host immune system. This metaanalysis aimed to assess the association of appendectomy at baseline with inflammatory bowel diseases. The PubMed, Cochrane library, and Google Scholar databases were systematically searched for relevant articles. The keywords used were inflammatory bowel disease, appendicitis, appendectomy, gut lymphoid tissue, Crohn's disease, ulcerative colitis with protean " AND " or " OR " . No limitation was applied to the time of publication. Out of the 622 references found, 32 full texts were screened, and only eight studies fulfilled the inclusion and exclusion criteria. There were fifteen cohorts from eight studies (five were published in Europe, two were from Asia, and one from South America with 9703 participants and 1150 events). The overall effects showed a negative impact of appendectomy on the rate of Crohn's disease, odd ratio,

show abstract

“…31 Conversely, a strong protective effect was found toward UC (OR, 0.39; 95% CI, 0.29-0.52) ( Figure 2 and Supplementary Tables 1 and 2). [32][33][34] Individuals with a first-degree relative diagnosed with appendicitis are at reduced risk of UC, particularly when there is a family predisposition to UC. 87 Tonsillectomy.…”

Section: Surgeriesmentioning

confidence: 99%

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

et al. 2019

View full text Add to dashboard Cite

Our study protocol was registered with PROSPERO (registration number: CRD42018112214). We followed a standardized methodology 7 and report findings according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (ie, PRISMA) 8 and Meta-analyses of Observational Studies in Epidemiology (ie, MOOSE) 9 recommendations. Search Strategy We systematically searched PubMed, Embase, and Scopus from inception through September 28, 2018, to identify metaanalyses of studies assessing the association between environmental factors and IBD. Search terms included inflammatory bowel disease, Crohn's disease, or ulcerative colitis, combined with systematic review or meta-analysis. We excluded conference abstracts, letters, editorials, and articles published in languages other than English. The reference lists of the identified meta-analyses were screened for additional eligible articles. No other restrictions were imposed.

show abstract

Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis

Cited by 20 publications

References 23 publications

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Appendectomy Impact on Inflammatory Bowel Diseases: A Meta-Analysis

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

Contact Info

Product

Resources

About