Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration

CFH,VEGFandHTRA1promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration

“…Possession of the high-risk A allele is associated with increased levels of the HTRA1 protein in drusen, retinal pigment epithelium and choroidal neovascular membranes of eyes with AMD 3 4. Chowers found no association between the HTRA1 promoter genotype and the visual acuity outcome or number of injections after PDT 24.…”

“…Polymorphisms in the promoter region of the HTRA1 (high-temperature requirement factor A-1) gene have been shown to increase susceptibility to AMD, especially the neovascular form, in Caucasian and other populations 3 4. Possession of the high-risk A allele is associated with increased levels of the HTRA1 protein in drusen, retinal pigment epithelium and choroidal neovascular membranes of eyes with AMD 3 4.…”

Genetic Association with Response to Intravitreal Ranibizumab for Neovascular Age-Related Macular Degeneration in the Han Chinese Population

“…Polymorphisms in the promoter region of the HTRA1 gene have been shown to increase susceptibility to AMD, especially the neovascular form, in both Caucasian and Asian populations [24,25]. Furthermore, 2 studies have suggested that there may be an association between treatment outcome with ranibizumab therapy and HTRA1 genetic variants for neovascular AMD in the Caucasian population [18,19].…”

Association between vascular endothelial growth factor +936 C/T gene polymorphism and age-related macular degeneration

“…14 Further associations have been found through metaanalyses, including the LOC387715/ HTRA1 gene, 50 the human high-temperature requirement A-1 gene -512 G/A 51 and rs11200638 in the promoter of HTRA1 gene. 52 A systematic review and meta-analysis of eight studies found strong evidence for an association between complement factor H and AMD, and indicated a multiplicative model (with each C allele increasing the odds of AMD by approximately 2.5-fold). 52 A meta-analysis from 15 case-control studies (8905 participants) indicated strong protective effects against AMD for the variant alleles of four SNPs in the CFB/C2 gene (rs9332739, rs547154, rs4151667 and rs641153).…”