Meta-Analysis of the Effect of Proton Pump Inhibitors on Obstructive Sleep Apnea Symptoms and Indices in Patients with Gastroesophageal Reflux Disease

Rassameehiran, Supannee; Klomjit, Saranapoom; Hosiriluck, Nattamol; Nugent, Kenneth

doi:10.1080/08998280.2016.11929340

Cited by 14 publications

(19 citation statements)

References 27 publications

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“…In patients with mild OSA and documented GERD, rabeprazole 20 mg twice daily for 2 months improved not only upper airway abnormalities but also objective and subjective parameters of sleep quality . A meta‐analysis proposed that proton pump inhibitor (PPI) treatment may improve sleep quality without any effect on AHI . There has been no recent human‐based research regarding the effect of continuous positive airway pressure (CPAP) therapy on GER in OSA patients since the study by Tawk et al ., in which CPAP seemed to be effective in OSA patients with heartburn symptoms.…”

Section: Is There Any Causal Relationship Between Gerd and Osa?mentioning

confidence: 99%

Gastroesophageal reflux disease: recent advances and its association with sleep

2016

Annals of the New York Academy of Sciences

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Gastroesophageal reflux disease (GERD) is prevalent in Asia as well as in Western countries. Sleep disturbance and breathing disorders during sleep are becoming increasingly prevalent, and they are commonly associated with GERD. The relationship between GERD and obstructive sleep apnea (OSA) is still questionable, and it has expanded to include Barrett's esophagus. Nocturnal gastroesophageal reflux (nGER) symptoms might be clinically important in the explanation of this association. The therapy for reflux symptoms has resulted in improved subjective sleep parameters and enhanced sleep quality, thus supporting a direct relationship between GERD and sleep disturbance. This review discusses the epidemiology of sleep disturbances in GERD patients; the causative relationship between GERD and OSA, even though it remains an area of controversy; and the possible role of nGER in sleep problems. It also provides an update on the current state of knowledge linking GERD and sleep.

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Section: Is There Any Causal Relationship Between Gerd and Osa?mentioning

confidence: 99%

Gastroesophageal reflux disease: recent advances and its association with sleep

2016

Annals of the New York Academy of Sciences

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“…The Agency for Healthcare Research and Quality (AHRQ) concluded that PPIs were superior to H2 receptor antagonists for resolving GERD symptoms at four weeks and healing esophagitis at eight weeks [42]. The AHRQ observed no opposition between individual PPIs to reduce symptoms at eight weeks.…”

Section:  Proton Pump Inhibitorsmentioning

confidence: 99%

“…For symptom relief at four weeks, esomeprazole 20 mg was equivalent, but esomeprazole 40 mg superior to omeprazole 20 mg [41]. The impacts of PPI in obstructive sleep apnea in patients with GERD noticed a lack of definitive data [42].…”

Section:  Proton Pump Inhibitorsmentioning

confidence: 99%

Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease

Hassan¹

2020

IJMBS

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Background: Gastroesophageal reflux is defined as a common physiologic phenomenon encountered intermittently by a large population, especially following a feed. Gastroesophageal reflux disease (GERD) happens if the number of gastric juice that refluxes into the esophagus passes the accepted limit, making symptoms with or without correlated esophageal mucosal injury (i.e., esophagitis). Diagnosis and treatment guidelines of gastroesophageal reflux disease (GERD) were announced in 1995 and updated in 2005 and lastly reviewed in 2013 by the American College of Gastroenterology (ACG). These and other guidelines undergo periodic review. Advances continue to be made in GERD, leading us to review and revise previous guideline statements. Here we aimed to review the different updated guidelines of diagnosis and treatment of Gastroesophageal reflux disease (GERD). A web-based search utilizing the advanced characteristics of different databases like PubMed, Google Scholar, Embase, Scopus, and Cochrane electronic databases was carried out. Keywords: Gastroesophageal reflux disease (GERD), Updates, Guidelines, Diagnosis, and Treatment.

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“…For example, oesophageal reflux is clearly linked to huge variations in intrathoracic pressure during apnoeas and hypopnoeas, and it is plausible that proton pump inhibitors were used in this indication. Accordingly, a recent systematic review and meta‐analysis concluded that proton pump inhibitors might improve the quality of sleep in OSA patients with concomitant gastroesophageal reflux disease, without any effect on apnoea–hypopnoea indices . Along the same lines, OSA is highly prevalent in patients with multiple sclerosis and this might explain the pharmacovigilance signal observed for interferons.…”

Section: Nomenclature Of Targets and Ligandsmentioning

confidence: 99%