Meta-analysis of the effectiveness of prophylactic drug therapy in preventing supraventricular arrhythmia early after coronary artery bypass grafting

Kowey, Peter R.; Taylor, J.; Rials, Seth J.; Marinchak, Roger A.

doi:10.1016/0002-9149(92)90802-6

Cited by 220 publications

(61 citation statements)

References 19 publications

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“…Kaireviciute et al showed that digoxin does not show any benefit for POAF prophylaxis (OR 0.97, 95% CI 0.62 -1.49) 39 , just like in our study. A subgroup analysis in a meta-analysis of calcium-antagonists found that nondihydropyridines significantly suppressed post-surgery supraventricular arrhythmias (OR 0.62, 95% CI 0.41-0.93), but with a high heterogeneity (p = 0.03).…”

Section: Discussionsupporting

confidence: 80%

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

Vukićević¹,

Putnik²,

Potpara³

2016

Srce i krvni sudovi

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Section: Discussionsupporting

confidence: 80%

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

Vukićević¹,

Putnik²,

Potpara³

2016

Srce i krvni sudovi

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“…2 Beta-blocker prophylaxis reduces the incidence of AF post-CTS. 3,4 Despite beta-blocker use, the incidence of AF remains approximately 30% and could be due to inadequate dosing clinically and the withdrawal of beta-blockade before postoperative day 3. 2,[5][6][7] Amiodarone, sotalol, and biatrial pacing are acceptable alternative strategies.…”

mentioning

confidence: 99%

Intravenous Plus Oral Amiodarone, Atrial Septal Pacing, or Both Strategies to Prevent Post-Cardiothoracic Surgery Atrial Fibrillation: The Atrial Fibrillation Suppression Trial II (AFIST II)

et al. 2003

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Background-The effect of a hybrid intravenous and oral prophylactic amiodarone regimen on postcardiothoracic surgery (CTS) atrial fibrillation (AF) is unknown. The impact of active atrial septal pacing on post-CTS AF has not been well characterized. In addition, the effect of using both amiodarone and atrial septal pacing together to prevent atrial fibrillation is unknown. Methods and Results-Patients (nϭ160) were randomized to amiodarone or placebo and then to pacing or no pacing using a 2ϫ2 factorial design. All therapies began within 6 hours post-CTS. Amiodarone was given by intravenous infusion for the first 24 hours (1050 mg total) followed by oral therapy for 4 postoperative days (4800 mg total). Atrial septal pacing was given for 96 hours. Amiodarone reduced the risk of AF by 43% and the risk of symptomatic AF by 68% (Pϭ0.037 and Pϭ0.019) versus placebo. Atrial septal pacing did not reduce AF or symptomatic AF incidence versus no pacing. The risk of post-CTS AF in the patients receiving amiodaroneϩpacing was lower than the placeboϩno pacing and the placeboϩpacing groups (57.9% and 60.5% reductions, Pϭ0.047 and Pϭ0.040, respectively). Conclusions-Amiodarone given as both an intravenous and oral regimen is effective at reducing post-CTS AF but atrial septal pacing is ineffective. Combining amiodarone and pacing is better than placebo with or without pacing but not amiodarone alone.

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“…While the use of a pacemaker in the surgical procedure provides a protective effect for the patient, being 65 years of age or more predisposes have limited use due to its side effects and contraindications for some patients, and also because it needs to be initiated a few days before surgery. Despite the use of such a scheme, a significant incidence of this arrhythmia was observed in this population 3,9,10,22,23 .…”

Section: Discussionmentioning

confidence: 85%

“…Although prophylactic therapy with beta-adrenergic antagonists 3,4,[7][8][9] , amiodarone 3,10 , and sotalol 11 may reduce the incidence of postoperative atrial fibrillation after myocardial revascularization, this condition remains an important cause of prolonged hospital stay.…”

Section: Introductionmentioning

confidence: 99%

Influência da estimulação biatrial temporária externa na prevenção da fibrilação atrial no pós-operatório de revascularização miocárdica sem circulação extracorpórea

Silva¹,

Milani²,

Précoma³

et al. 2008

Arq. Bras. Cardiol.

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Meta-analysis of the effectiveness of prophylactic drug therapy in preventing supraventricular arrhythmia early after coronary artery bypass grafting

Cited by 220 publications

References 19 publications

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

Intravenous Plus Oral Amiodarone, Atrial Septal Pacing, or Both Strategies to Prevent Post-Cardiothoracic Surgery Atrial Fibrillation: The Atrial Fibrillation Suppression Trial II (AFIST II)

Influência da estimulação biatrial temporária externa na prevenção da fibrilação atrial no pós-operatório de revascularização miocárdica sem circulação extracorpórea

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