Meta-analysis of the efficacy of the fentanyl iontophoretic transdermal system versus intravenous patient-controlled analgesia in postoperative pain management

Sinatra, Raymond S.; Viscusi, Eugene R.; Ding, Li; Danesi, Hassan; Grond, Stefan

doi:10.1517/14656566.2015.1054279

Cited by 14 publications

(5 citation statements)

References 13 publications

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“…However, for others, it was suggested that fentanyl was equally effective as morphine and was considered to be the opioid of choice. 9 , 12 , 13 So, the safety and efficacy of cancer pain treatment needs further exploration. The objective of this meta-analysis was to compare the safety and efficacy of fentanyl and morphine among cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Fentanyl Compared With Morphine among Adult Patients with Cancer: A Meta-Analysis

Manirakiza¹,

Irakoze

Manirakiza

et al. 2020

EAHRJ

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Background: Cancer pain is experienced by numerous patients; thus, the main pain-relieving opioid analgesics, fentanyl and morphine, are of great importance. However, their analgesic efficacy and safety are different among individuals and are still controversial. The aim of this study was to compare the safety and efficacy of fentanyl and morphine among patients with cancer. Methods: We performed a meta-analysis by searching PubMed and the Cochrane Library up to 01 April 2019. The search terms were fentanyl, morphine, opioids and cancer pain. All randomised controlled trials comparing fentanyl and morphine were included in the analysis. Results: Overall, the initial search identified 2970 published studies; among them, 9 studies were included in the efficacy analysis and 8 studies were included in the safety analysis. The oral morphine versus oral transmucosal fentanyl subgroup analysis showed a mean difference(MD)=0.47[Confidence interval(CI):0.35-0.58] with an overall effect, Z=8.10, P<.00001. The outcome of the oral morphine versus nasal/transdermal fentanyl subgroup indicated a MD=0.20[CI:0.3-0.37] with an overall effect, Z=2.24 and P=.02. For the oral morphine versus buccal/sublingual fentanyl subgroup, the analysis revealed a MD=1.80[CI:1.35-2.25] with an overall effect, Z=7.87 and P<.00001. The oral morphine versus other forms of fentanyl subgroup showed a MD=0.70[95%CI:0.34-1.06] with the test for the overall effect, Z=3.81 and P=.0001. Constipation, drowsiness, confusion and dry mouth were more common in the morphine group than in the fentanyl group, with a risk ratio=0.60[

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Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Fentanyl Compared With Morphine among Adult Patients with Cancer: A Meta-Analysis

Manirakiza¹,

Irakoze

Manirakiza

et al. 2020

EAHRJ

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“…4 Zunehmend setzten sich auch individualisierte, an die jeweilige patientenspezifische Situation angepasste therapeutische Strategien durch. 4 Optionen der patientenkontrollierten Analgesie (PCA) gewinnen an Bedeutung, auch vor dem Hintergrund neuer Verabreichungsformen [60,62,64,79,106,109,111,146]. 4 Es werden klare Grenzwerte für schmerztherapeutische Interventionen definiert.…”

Section: Introductionunclassified

Interdisziplinäres Positionspapier „Perioperatives Schmerzmanagement“

Likar

Jaksch

Aigmüller

et al. 2017

Schmerz

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Despite many positive developments, postoperative pain and its treatment is still not always given the necessary attention. Severe pain after surgical procedures affects a significant proportion of patients. This very fact is not only detrimental to the immediate recovery process, but can also form the basis for the development of chronic pain conditions.An adequate and effective management of perioperative pain requires appropriate organizational structures. This multidisciplinary paper which was initiated by the Austrian Society for Anaesthesiology and Intensive Care and the Austrian Pain Society and developed together with numerous specialist and professional societies dealing with the subject aims at supporting the organization of perioperative pain management structures and to make best use of proven concepts. Additional recommendations describe specific interventions for selected types of intervention.

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“…The efficacy and safety of the FITS in postoperative pain management have been demonstrated in several published placebo-and IV morphine PCA-controlled phase III clinical trials conducted with the original delivery system in patients undergoing orthopedic, abdominal, thoracic or pelvic surgery [72][73][74][75][76][77] . Meta-analyses have confirmed the efficacy of the FITS, including its EOC profile, compared with conventional PCA [78][79][80][81][82] .…”

Section: Fentanyl Iontophoretic Transdermal Systemmentioning

confidence: 90%

Non-invasive patient-controlled analgesia in the management of acute postoperative pain in the hospital setting

Morlion

Schäfer

Betteridge

et al. 2018

Current Medical Research and Opinion

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Evidence-based guidelines for acute postoperative pain management support the use of multimodal regimens in many situations. As effective and safe alternatives to conventional PCA, and with the added benefits of being non-invasive, easy to use and allowing early patient mobilization, the newer PCA systems may complement multimodal approaches, or potentially replace certain regimens, in hospitalized patients with acute postoperative pain.

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Meta-analysis of the efficacy of the fentanyl iontophoretic transdermal system versus intravenous patient-controlled analgesia in postoperative pain management

Cited by 14 publications

References 13 publications

Efficacy and Safety of Fentanyl Compared With Morphine among Adult Patients with Cancer: A Meta-Analysis

Efficacy and Safety of Fentanyl Compared With Morphine among Adult Patients with Cancer: A Meta-Analysis

Interdisziplinäres Positionspapier „Perioperatives Schmerzmanagement“

Non-invasive patient-controlled analgesia in the management of acute postoperative pain in the hospital setting

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