Meta-Analysis of the Functional Neuroanatomy of Single-Word Reading: Method and Validation

Turkeltaub, Peter E.; Eden, Guinevere F.; Jones, Karen; Zeffiro, Thomas A.

doi:10.1006/nimg.2002.1131

Cited by 1,395 publications

(1,329 citation statements)

References 35 publications

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“…This combined approach identified 21 potential articles. As primary source data must be reported in standard stereotactic coordinates (either Talairach or MNI space) to be used in voxel-level quantitative meta-analyses [Laird et al, 2005a;Turkeltaub et al, 2002], only 17 articles could be included in the review. Of these articles, only those that reported coordinates from patients with schizophrenia alone (n ϭ 7) or coordinates from patient-control contrasts were included (n ϭ 6; total n ϭ 12; see Table I).…”

Section: Literature Searchmentioning

confidence: 99%

“…Activation likelihood estimation (ALE) is a relatively new method of quantitative meta-analysis of functional neuroimaging data developed by Turkeltaub et al [2002] and significantly expanded by Laird et al [2005a]. ALE is a voxel-based method for finding concordance within a neuroimaging literature that does not rely upon author-assigned anatomical labels [Laird et al, 2005b].…”

Section: Quantitative Meta-analysis Proceduresmentioning

confidence: 99%

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Beyond hypofrontality: A quantitative meta‐analysis of functional neuroimaging studies of working memory in schizophrenia

Glahn

Ragland

Abramoff

et al. 2005

Human Brain Mapping

557

393

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Abstract:Although there is considerable evidence that patients with schizophrenia fail to activate the dorsolateral prefrontal cortex (DLPFC) to the degree seen in normal comparison subjects when performing working memory or executive tasks, hypofrontality may be coupled with relatively increased activity in other brain regions. However, most imaging studies of working memory in schizophrenia have focused on DLPFC activity. The goal of this work is to review functional neuroimaging studies that contrasted patients with schizophrenia and healthy comparison subjects during a prototypical working memory task, the n-back paradigm, to highlight areas of hyper-and hypoactivation in schizophrenia. We utilize a quantitative metaanalysis method to review 12 imaging studies where patients with schizophrenia were contrasted with healthy comparison subjects while performing the n-back paradigm. Although we find clear support for hypofrontality, we also document consistently increased activation in anterior cingulate and left frontal pole regions in patients with schizophrenia compared to that in controls. These data suggest that whereas reduced DLPFC activation is reported consistently in patients with schizophrenia relative to healthy subjects, abnormal activation patterns are not restricted to this region, raising questions as to whether the pathophysiological dysfunction in schizophrenia is specific to the DLPFC and about the relationship between impaired performance and aberrant activation patterns. The complex pattern of hyper-and hypoactivation consistently found across studies implies that rather than focusing on DLPFC dysregulation, researchers should consider the entire network of regions involved in a given task when making inferences about the biological mechanisms of schizophrenia. Hum Brain Mapp 25:60 -69, 2005.

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Section: Literature Searchmentioning

confidence: 99%

Section: Quantitative Meta-analysis Proceduresmentioning

confidence: 99%

Beyond hypofrontality: A quantitative meta‐analysis of functional neuroimaging studies of working memory in schizophrenia

Glahn

Ragland

Abramoff

et al. 2005

Human Brain Mapping

557

393

View full text Add to dashboard Cite

show abstract

“…It should also be possible to conduct searches for sets of coordinates, so that it is possible to search for networks (i.e., find papers that report activations within a set of locations). In addition, we consider it important that quantitative meta-analyses (Chein et al, 2002;Laird et al, 2005a;Turkeltaub et al, 2002;Wager & Smith, 2003) be included in the database and it be possible to restrict searches to these types of papers. This would allow for the identification of relevant papers on a meta-level.…”

Section: How To Search?mentioning

confidence: 99%

Lost in localization: The need for a universal coordinate database

Derrfuß

Mar

2009

NeuroImage

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“…There has been a large body of research using meta‐analytical approaches in the field of single‐word recognition (Jobard, Crivello, & Tzourio‐Mazoyer, 2003; Martin, Schurz, Kronbichler, & Richlan, 2015; Taylor, Rastle, & Davis, 2013; Turkeltaub, Eden, Jones, & Zeffiro, 2002). In general, our results were in agreement with previous findings that ventral regions, such as the VOT, MTG, and IFG, are activated during single word processing.…”

Section: Discussionmentioning

confidence: 99%

A meta‐analysis of functional magnetic resonance imaging studies of eye movements and visual word reading

Zhou

Shu

2017

Brain and Behavior

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IntroductionThe pattern of eye movements during reading is substantially correlated with linguistic factors. While there have been a large number of studies on the neural mechanisms of eye movements and word reading separately, a limited number of studies have compared the activation patterns of these two processes and discussed the associations of their corresponding brain regions within the framework of naturalistic reading.MethodsThis study conducted a meta‐analysis of the existing functional magnetic resonance imaging literature on prosaccades and visual word reading using the activation likelihood estimation algorithm.ResultsOur main finding was that, although prosaccades and word reading mainly activated dorsal and ventral brain areas, respectively, they both activated the left precentral gyrus (PreCG), left superior parietal lobe, right PreCG, right lingual gyrus, and bilateral medial frontal gyrus.ConclusionThese findings provide new insights into cognitive processes involved with naturalistic reading, which requires both eye movements and word reading.

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Meta-Analysis of the Functional Neuroanatomy of Single-Word Reading: Method and Validation

Cited by 1,395 publications

References 35 publications

Beyond hypofrontality: A quantitative meta‐analysis of functional neuroimaging studies of working memory in schizophrenia

Beyond hypofrontality: A quantitative meta‐analysis of functional neuroimaging studies of working memory in schizophrenia

Lost in localization: The need for a universal coordinate database

A meta‐analysis of functional magnetic resonance imaging studies of eye movements and visual word reading

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