Meta-analysis of the Impact of Nine Medication Classes on Falls in Elderly Persons

Gandelman, Jason; Ureste, Peter

doi:10.1007/978-3-030-94960-0_3

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…For instance, the long-term efficacy of BZD anxiolytics is yet unknown, hence their long-term usage is not advised for the treatment of anxiety disorders. In addition, long-term BZD usage has been linked to adverse effects, including cognitive decline [69], fractures from falls [70], and impaired driving [71]. A thorough knowledge of the dynamic interactions taking place within the dispersed networks underpinning anxiety is required before the brain circuits for anxiety disease can be fully appreciated.…”

Section: Discussionmentioning

confidence: 99%

Research on the neural circuits and treatment of anxiety

Cai

2023

TNS

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Anxiety disorders are widely recognized as one of the most widespread mental health conditions worldwide, which can have detrimental impacts on individuals, their families, and the broader communities they belong to. A clearer knowledge of the brain neural circuits linked to anxiety will be beneficial for early detection of at-risk individuals and the ability to take preventative interventions. Today, more specialized and individualized therapies for anxiety disorders have been developed as a result of neuroscientific research. The neural circuitry involves key brain regions like the amygdala, prefrontal cortex (PFC), anterior cingulate cortex (ACC), bed nucleus of the stria terminalis (BNST), and hippocampus, unraveling complex interactions contributing to anxiety pathogenesis. Treatment modalities are categorized as medicine and non-medicine approaches. This paper emphasizes the necessity for ongoing research to optimize therapeutic approaches and advocates combining pharmacological and non-medicine interventions for comprehensive anxiety disorder management, ultimately improving the well-being of affected individuals worldwide.

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Section: Discussionmentioning

confidence: 99%

Research on the neural circuits and treatment of anxiety

Cai

2023

TNS

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“…For the analysis, this confounding factor was inserted as a continuous variable. Other covariates were the number of falls in the last 12 months [ 81 ], the number of different types of medications consumed daily [ 82 , 83 ], and comorbidities [ 84 , 85 ]. All this information was obtained through face-to-face interviews.…”

Section: Methodsmentioning

confidence: 99%

The Effects of 12-Week Dual-Task Physical–Cognitive Training on Gait, Balance, Lower Extremity Muscle Strength, and Cognition in Older Adult Women: A Randomized Study

Nascimento

Maduro

Rios

et al. 2023

IJERPH

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This study aims to investigate the effects of dual-task physical–cognitive the training on body balance (BB), gait performance (GP), lower limb muscle strength (LEMS), and cognitive performance (CP) in a group of cognitively normal older adult women (n = 44; 66.20 ± 4.05 years). Of these, 22 were randomly allocated to the dual-task training (DT) group, and 22 participated in the control group (CG). Assessments were performed at baseline, after 12 weeks of intervention, and at the end of 12 weeks of follow-up, using the following instruments: Timed Up & Go (TUG), Timed Up & Go manual (TUGm), Timed Up & Go cognitive (TUGc), Balance Test (TEC), sit-to-stand test (STS), and verbal fluency test (VF). After 12 weeks of DT training, participants showed a significant time × group interaction in all motor assessments (BB, GP, LEMS), as well as in three cognitive tests (VF-grouping, VF-exchange, VF-total). No time–group interaction effect was indicated for the VF-category test. At all evaluation times, CG members maintained constant physical and cognitive performance. We conclude that 12 weeks of physical–cognitive DT training was effective in promoting BB, GP, and LEMS, as well as CP in cognitively normal older adult women, with lasting effects up to 12 weeks after the intervention.

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The impact of patient-facility language discordance on potentially inappropriate prescribing of antipsychotics in long-term care home in Ontario, Canada: a retrospective population health cohort study

Reaume,

Peixoto,

Pugliese

et al. 2024

BMC Geriatr

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Background Appropriate use of medication is a key indicator of the quality of care provided in long-term care (LTC). The objective of this study was to determine whether resident-facility language concordance/discordance is associated with the odds of potentially inappropriate prescribing of antipsychotics (PIP-AP) in LTC. Methods We conducted a population-based, retrospective cohort study of LTC residents in Ontario, Canada from 2010 to 2019. We obtained resident language from standardized resident assessments, and derived facility language by determining the proportion of residents belonging to each linguistic group within individual LTC homes. Using linked administrative databases, we identified all instances of PIP-AP during a 1-year follow-up period. PIP-AP was defined using the STOPP-START criteria, which have previously been shown to predict adverse clinical events such as emergency department (ED) visits and hospitalizations. The association between linguistic factors and PIP-AP was assessed using adjusted multivariable logistic regression analysis. Results We identified 198,729 LTC residents consisting of 162,814 Anglophones (81.9%), 6,230 Francophones (3.1%), and 29,685 Allophones (14.9%). The odds of PIP-AP of were higher for both Francophones (aOR 1.15, 95% CI 1.08–1.23) and Allophones (aOR 1.11, 95% CI 1.08–1.15) when compared to Anglophones. When compared to English LTC homes, French LTC homes had greater odds of PIP-AP (aOR 1.12, 95% CI 1.05–1.20), while Allophone homes had lower odds of PIP-AP (aOR 0.82, 95% CI 0.77–0.86). Residents living in language-discordant LTC homes had higher odds of PIP-AP when compared to LTC residents living in language-concordant LTC homes (aOR 1.07, 95% CI 1.04–1.10). Conclusion This study identified linguistic factors related to the odds of PIP-AP in LTC, suggesting that the linguistic environment may have an impact on the quality of care provided to residents. Supplementary Information The online version contains supplementary material available at 10.1186/s12877-024-05446-8.

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Meta-analysis of the Impact of Nine Medication Classes on Falls in Elderly Persons

Cited by 4 publications

References 5 publications

Research on the neural circuits and treatment of anxiety

Research on the neural circuits and treatment of anxiety

The Effects of 12-Week Dual-Task Physical–Cognitive Training on Gait, Balance, Lower Extremity Muscle Strength, and Cognition in Older Adult Women: A Randomized Study

The impact of patient-facility language discordance on potentially inappropriate prescribing of antipsychotics in long-term care home in Ontario, Canada: a retrospective population health cohort study

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