Meta-analysis of the Relation Between the VDR Gene TaqIpolymorphism and Genetic Susceptibility to Prostate Cancer in Asian Populations

Guo, Yinlong; Shi, Zhou; Liu, Jun-Da; Lei, Ning; Chen, Qiuhong; Tang, Ying

doi:10.7314/apjcp.2012.13.9.4441

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…Some VDR meta-analyses have been published ( Touvier et al , 2011 ; Bai et al , 2012 ; Guo et al , 2012 ; Huang et al , 2013 ; Liu et al , 2013 ; Song and Lee, 2013 ; Wang et al , 2013 ; Xu et al , 2014 ), but differently from others, here we analyzed all cancer sites with a panel of different SNPs and we investigated sources of heterogeneity, including ethnicity, which seems to explain much of the between-study variation. The Huang group showed an overall 16% increased risk, increasing to 31% in African-American patients for Cdx2 SNP (variant homozygous condition versus the heterozygote plus the wild-type genotype) for any cancer.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis on vitamin D receptor and cancer risk

Serrano¹,

Gnagnarella

Raimondi

et al. 2016

European Journal of Cancer Prevention

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Vitamin D plays a significant role in our health, including cancer incidence and mortality. Vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) may affect its activity, influencing the risk of cancer. Several studies have investigated VDR SNPs, but the association with the risk of cancer is controversial. Here, we present a meta-analysis to assess the association of TaqI, ApaI, and Cdx2 SNPs with the risk of cancer. A systematic literature search was performed following a predefined protocol and using validated search strategies. This meta-analysis shows the summary odd ratio (SOR) overall, by cancer sites and by ethnicity. Up to January 2014, we identified 73 independent studies with 35 525 cases and 38 675 controls. The meta-analysis of Cdx2 gg versus GG showed a significant 12% increased risk for all cancers [SOR=1.12; 95% confidence interval (CI): 1.00–1.25]. The other SNPs analyzed did not show an overall significant association with the risk of cancer: SOR=0.98 (95% CI: 0.90–1.07) and 1.06 (95% CI: 0.95–1.19) for TaqI tt versus TT and ApaI aa versus AA, respectively. TaqI shows a significant 43% increased risk for colorectal cancer (SOR=1.43; 95% CI: 1.30–1.58 for tt vs. TT). Strong frequency variations are present among different ethnic groups. This meta-analysis showed an overall increased risk of cancer associated with Cdx2 SNP and a specific higher risk of colorectal cancer associated with the TaqI polymorphism. The VDR genotype might become more relevant when clustered in a specific haplotype, associated with other SNPs of genes involved in vitamin D metabolism, or for specific tumors and/or patient characteristics.

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Section: Discussionmentioning

confidence: 99%

Meta-analysis on vitamin D receptor and cancer risk

Serrano¹,

Gnagnarella

Raimondi

et al. 2016

European Journal of Cancer Prevention

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“…The vitamin D receptor has a number of common coding polymorphisms that have been investigated in association with LUTS or prostate cancer. One noncoding SNP in the 3′ region, rs731236, which is associated with increased serum vitamin D levels, may have a protective benefit against prostate cancer [45] , at least in some populations. In five studies in ethnically diverse populations of its association with LUTS [46–50] , there was a consistent protective effect of the minor allele, with a large pooled effect size (OR: 0.64; 95% CI, 0.49–0.83) and moderate heterogeneity (I 2 = 27.2%) ( Fig.…”

Section: Evidence Synthesismentioning

confidence: 99%

Systematic Review and Meta-analysis of Candidate Gene Association Studies of Lower Urinary Tract Symptoms in Men

et al. 2014

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ContextAlthough family studies have shown that male lower urinary tract symptoms (LUTS) are highly heritable, no systematic review exists of genetic polymorphisms tested for association with LUTS.ObjectiveTo systematically review and meta-analyze studies assessing candidate polymorphisms/genes tested for an association with LUTS, and to assess the strength, consistency, and potential for bias among pooled associations.Evidence acquisitionA systematic search of the PubMed and HuGE databases as well as abstracts of major urologic meetings was performed through to January 2013. Case-control studies reporting genetic associations in men with LUTS were included. Reviewers independently and in duplicate screened titles, abstracts, and full texts to determine eligibility, abstracted data, and assessed the credibility of pooled associations according to the interim Venice criteria. Authors were contacted for clarifications if needed. Meta-analyses were performed for variants assessed in more than two studies.Evidence synthesisWe identified 74 eligible studies containing data on 70 different genes. A total of 35 meta-analyses were performed with statistical significance in five (ACE, ELAC2, GSTM1, TERT, and VDR). The heterogeneity was high in three of these meta-analyses. The rs731236 variant of the vitamin D receptor had a protective effect for LUTS (odds ratio: 0.64; 95% confidence interval, 0.49–0.83) with moderate heterogeneity (I2 = 27.2%). No evidence for publication bias was identified. Limitations include wide-ranging phenotype definitions for LUTS and limited power in most meta-analyses to detect smaller effect sizes.ConclusionsFew putative genetic risk variants have been reliably replicated across populations. We found consistent evidence of a reduced risk of LUTS associated with the common rs731236 variant of the vitamin D receptor gene in our meta-analyses.Patient summaryCombining the results from all previous studies of genetic variants that may cause urinary symptoms in men, we found significant variants in five genes. Only one, a variant of the vitamin D receptor, was consistently protective across different populations.

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“…However, an updated meta-analysis for prostate cancer risk showed an association in Asian populations for TaqI [41], but FokI and BsmI in diverse populations showed no significant associations [42]. Lack of association has also been reported in colorectal cancer outcomes [43].…”

Section: Introductionmentioning

confidence: 99%

An Integrated Approach to Defining Genetic and Environmental Determinants for Major Clinical Outcomes Involving Vitamin D

Berlanga‐Taylor

Knight

2014

Mol Diagn Ther

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There is substantial genetic and epidemiological evidence implicating vitamin D in the pathogenesis of many common diseases. A number of studies have sought to define an association for disease with sequence variation in the VDR gene, encoding the ligand-activated nuclear hormone receptor for vitamin D. The results of such studies have been difficult to replicate and are likely to need to account for specific environmental exposures. Here, we review recent work that has begun to study the interactions between VDR gene polymorphisms, vitamin D blood levels, and complex disease susceptibility, notably in the context of major clinical outcomes. We highlight the challenges moving forward in this area and its importance for effective clinical translation of current research.

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Meta-analysis of the Relation Between the VDR Gene TaqIpolymorphism and Genetic Susceptibility to Prostate Cancer in Asian Populations

Cited by 9 publications

References 22 publications

Meta-analysis on vitamin D receptor and cancer risk

Meta-analysis on vitamin D receptor and cancer risk

Systematic Review and Meta-analysis of Candidate Gene Association Studies of Lower Urinary Tract Symptoms in Men

An Integrated Approach to Defining Genetic and Environmental Determinants for Major Clinical Outcomes Involving Vitamin D

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