Meta-analysis of the relationship between depression and diabetic retinopathy

Wu, Chao; You, Zhipeng

doi:10.4066/biomedicalresearch.29-17-2963

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…From 1,834 initial hits, 663 duplicates were automatically removed, leaving 1171 titles and abstracts to be assessed. After retrieving and assessing 51 full text articles following title and abstract review, 11 systematic reviews [5,7,8,[28][29][30][31][32][33][34][35] with meta-analyses were included with a total of 16 independent outcomes, with a total of 413,142 participants (median participants per outcome 7,266). Table 2 shows descriptive statistics of included studies and Supplementary Table 2 shows a list of full text studies that were assessed and excluded, with justifications.…”

Section: Searchmentioning

confidence: 99%

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Associations between diabetic retinopathy, mortality, disease, and mental health: an umbrella review of observational meta-analyses

2022

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Background Diabetic retinopathy is a complication of diabetes affecting the eyes and can lead to blindless if left untreated. Several significant risk factors have been reported for DR, of which several can be classified as some form of disease. Furthermore, several systematic reviews have reported associations between several types of mortality and DR. Numerous meta-analyses have pooled the data on these factors, however, a systematic evaluation of these meta-analytic relationships is lacking. In this study, therefore, we performed an umbrella review of systematic reviews of meta-analyses for mortality, diseases and DR, grading the credibility of evidence. Methods A comprehensive database search for observational meta-analyses was conducted from inception until 29/04/2022 against pre-published inclusion criteria. For each meta-analytic outcome, a random-effects meta-analysis was re-conducted, stratifying by study design (and type of DR where possible) of included studies. Several statistical variables, including publication bias, heterogeneity, excess significance bias, and prediction intervals were used to grade the credibility of significant evidence from I to IV, using the recommendations from the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria. Results Of the 1,834 initial results, 11 systematic reviews with meta-analyses were included covering 16 independent outcomes (total participants = 299,655; median participants per outcome: 7,266; median individual studies per outcome = 5). Overall, 10/16 outcomes (62.5%) yielded significant results, most of which were graded as ‘highly suggestive’ (Grade II) evidence. DR was associated with all-cause and cardio-vascular mortality, obstructive sleep apnoea, depression eating disorders, and several forms of cognitive impairment. Conclusions Results show highly suggestive evidence for associations between health outcomes and/or conditions and DR. Public health professionals and practitioners should note these findings when developing and/or reviewing public health polices.

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Section: Searchmentioning

confidence: 99%

“…Several systematic reviews with accompanying metaanalyses have been conducted examining associations between DR and wide range of conditions, including different types of mortality [5,6], mental health conditions [7], and other diseases [8] not typically associated with diabetes (e.g. obstructive sleep apnoea).…”

Section: Introductionmentioning

confidence: 99%

Associations between diabetic retinopathy, mortality, disease, and mental health: an umbrella review of observational meta-analyses

2022

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Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies

Trott

Smıth

Veronese

et al. 2021

Eye

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Importance: Globally, 2.2 billion people live with some form of vision impairment and/or eye disease. To date, most systematic reviews examining associations have focused on a single eye disease and there is no systematic evaluation of the relationships between eye diseases and diverse physical and mental health outcomes. Moreover, the strength and reliability of the literature is unclear.Objective: We performed an umbrella review of observational studies with meta analyses for any physical and/or mental comorbidities associated with eye disease. For each association, random-effects summary effect size, heterogeneity, small-study effect, excess significance bias and 95% prediction intervals were calculated, and used to grade significant evidence from convincing to weak. Findings: 34 studies were included covering 58 outcomes. No outcomes yielded convincing evidence, six outcomes yielded highly suggestive results (cataract positively associated with type 2 diabetes, open-angled glaucoma positively associated with myopia and diabetes, diabetic retinopathy positively associated with cardiovascular disease and cardiovascular mortality, and retinopathy of prematurity positively associated with chorioamnionitis), eight outcomes yielded suggestive results (diabetic retinopathy positively associated with all-cause mortality and depression, diabetic macular oedema positively associated with dyslipidaemia, cataract positively associated with gout, nuclear sclerosis positively associated with all-cause mortality, open angled glaucoma positively associated with migraine and hypertension, and age-related macular degeneration positively associated with diabetes), and 18 outcomes yielded weak evidence.

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Meta-analysis of the relationship between depression and diabetic retinopathy

Cited by 2 publications

References 24 publications

Associations between diabetic retinopathy, mortality, disease, and mental health: an umbrella review of observational meta-analyses

Associations between diabetic retinopathy, mortality, disease, and mental health: an umbrella review of observational meta-analyses

Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies

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