Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians

Zaso, Michelle J.; Goodhines, Patricia A.; Wall, Tamara L.; Park, Aesoon

doi:10.1093/alcalc/agz011

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…In fact, there is a lack of genomic studies in developing countries, especially investigating alcohol metabolizing enzyme genotypes in Caucasian samples. The majority of these studies have been conducted among Asian ethnicities or Asian descendants [55][56][57][58]. However, we were not able to find any significant genotypic association with abstinence in this trial.…”

Section: Discussioncontrasting

confidence: 61%

Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder

et al. 2021

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Background: The efficacy of naltrexone in the treatment of alcohol use disorder (AUD) has been associated with a set of variables not directly related with the expression of opioid receptors. All the variables have been found to be highly associated with AUD itself or more severe clinical levels of AUD. Objectives: Given the high association between alcohol metabolizing enzymes (AME) and the outcome of AUD, the present study aims to investigate the role of AME genotype variants in the treatment of AUD with naltrexone. Methods: We carried out a 12-week longitudinal clinical trial based on the treatment of AUD patients with naltrexone (N = 101), stratified by different alcohol metabolization genotypes. Genotyping was performed after the inclusion of the patients in the study, based on the individual presence of single nucleotide polymorphisms (SNPs) in the ADH (alcohol dehydrogenase)1B (ADH1B*2 and ADH1B*3), ADH1C (ADHC*1) and ALDH (aldehyde dehydrogenase) 2 (ALDH2*2) genes. The outcome of alcohol use has been monitored employing the timeline follow-back during the treatment. Results: The ADH1C*1 (Ile350Val, rs698) and ALDH2*2 (Glu504Lys, rs671) polymorphisms were associated with a better response to naltrexone treatment, whereas the ADH1B*3 (Arg370Cys, rs2066702) allelic variant showed a negative outcome. Conclusions: The present study explores a genomic setting for the treatment of AUD with naltrexone. According to our findings, the association between ADH1C*1 and ALDH2*2 variants and better outcomes suggests a successful treatment, whereas the ADH1B*3 mutated allele might lead to an unsuccessful treatment. Further studies should be performed to investigate the relationship between alcohol metabolizing genotypes, the family history of alcohol use disorders and the effect of naltrexone on the outcomes. Genotyping may be a valuable tool for precision-medicine and individualized approach, especially in the context of alcohol use disorders. The small number of subjects was the main limitation of the present study.

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Section: Discussioncontrasting

confidence: 61%

Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder

et al. 2021

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“…It is crucial to mention that findings from meta-analyses indicate the involvement of ALDH2 rs671 [ 108 , 109 , 110 ] and ADH1C rs698 [ 109 ] in Asian patients with AD, as well as the protective role of ADH1B rs1229984 against Asian AUD patients [ 109 , 110 , 111 ].…”

Section: Resultsmentioning

confidence: 99%

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

2022

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Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not fully elucidated. However, ethanol metabolism has been associated with increased oxidative stress through alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase metabolic pathways. We searched the PubMed and genome-wide association studies (GWAS) catalog databases to review the literature systematically and summarized the findings focusing on AUD and alcohol abstinence in relation to oxidative stress. In addition, we reviewed the ClinicalTrials.gov resource of the US National Library of Medicine to identify all ongoing and completed clinical trials that include therapeutic interventions based on antioxidants. The retrieved clinical and preclinical studies show that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.

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“…However, excessive production of acetate can lead to the inhibition of gluconeogenesis and fatty acid oxidation. [ 43 ] Hence, the consumption of alcohol can influence organ systems via its impact on nutrition or through the bioactivity of ethanol and its metabolites. Alcohol consumption is also related to skeletal health, fracture risk and osteoporosis, especially heavy drinking.…”

Section: Resultsmentioning

confidence: 99%

The relationship between healthy lifestyles and bone health

Sheng

Nüssler³

et al. 2021

Medicine

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Background Bone health, especially osteoporosis among ageing populations, has become an important topic for both clinical and basic researchers. The relationship between bone health and healthy lifestyles has been frequently discussed. The present study focuses on the relationship between bone health and healthy lifestyles among older adults, based on a global comparison. Methods This narrative review was performed by collecting clinical trials, basic research and reviews on lifestyle and bone health in PubMed database. Results Positive effects of physical activity and negative effects of malnutrition, alcohol abuse, and cigarette smoking on bone health were revealed. The relationship between bone health and drinking coffee and tea is still inconclusive. Moreover, the diversity of each region should be aware when considering healthy lifestyles to improve bone health. Conclusion Healthy lifestyles are highly related to bone health, and different lifestyles may have different influences on regions with a high risk of bone diseases. It is practical to acknowledge the diversity of economic, religious, environmental and geological conditions in each region when providing suitable and effective recommendations for healthy lifestyles that can improve overall bone health.

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Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians

Cited by 10 publications

References 39 publications

Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder

Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

The relationship between healthy lifestyles and bone health

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