Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern

Suhren, Jan-Theile; Meinardus, Andre; Hussein, Kais; Schaumann, Nora

doi:10.1016/j.placenta.2021.10.010

Cited by 48 publications

(62 citation statements)

References 50 publications

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“…Consistent with previous reports [2,4,11], over half of the placentas in our study had no significant gross or microscopic abnormalities. A minority of the placentas demonstrated MVM (22.6%) and/or AIUI (24.3%), and these placental findings were typically classified as mild.…”

Section: Discussionsupporting

confidence: 93%

“…Since the initiation of our study, there have been increasing reports on the effects of SARS-CoV-2 on the placenta. In a recent meta-analysis of these placental studies [2], no histological findings in the placenta were specific for COVID-19. Moreover, all studies to date have shown the incidence of trans-placental viral transmission to be very rare and when there is SARS-CoV-2 infection of the placenta, no specific viral changes have been noted [2].…”

Section: Introductionmentioning

confidence: 99%

“…In a recent meta-analysis of these placental studies [2], no histological findings in the placenta were specific for COVID-19. Moreover, all studies to date have shown the incidence of trans-placental viral transmission to be very rare and when there is SARS-CoV-2 infection of the placenta, no specific viral changes have been noted [2]. However, a recent small study [3] demonstrated that placentas positive for SARS-CoV-2 via RNA ISH demonstrated chronic histocytic intervillositis, perivillous fibrin deposition, and trophoblastic necrosis.…”

Section: Introductionmentioning

confidence: 99%

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The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies

Ward¹,

Cornaby²,

Kato

et al. 2022

Preprint

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Introduction: The effect of SARS-CoV-2 infection on pregnant mothers, the placenta, and infants is not fully understood and sufficiently characterized. Methods: We performed a retrospective, observational cohort study in Chapel Hill, NC of 115 mothers with SARS-CoV-2 and singleton pregnancies from December 1, 2019 to May 31, 2021. We performed a chart review to document the infant weight, length, head circumference, survival, congenital abnormalities, and hearing loss, maternal complications, and placental pathology classified by the Amsterdam criteria. Results: The average infant weight, length, and head circumference were all within the normal range for gestational age, the infants had no identifiable congenital abnormalities, and all infants and mothers survived. Only one infant (0.870%) became infected with SARS-CoV-2. Moderate and severe maternal COVID-19 were associated with increased caesarean section, premature delivery, infant NICU admission, and maternal respiratory failure, and were more likely in Type 1 (p=0.0055) and Type 2 (p=0.0285) diabetic mothers. Most placentas (n=63, 54.8%) showed normal or non-specific findings, while a subset had mild maternal vascular malperfusion (n=26, 22.6%) and/or mild microscopic ascending intrauterine infection (n=28, 24.3%). Discussion: Most mothers with SARS-CoV-2 and their infants had a routine clinical course. Maternal SARS-CoV-2 infection was not associated with intrauterine fetal demise, infant death, congenital abnormalities, or hearing loss. Infant infection with SARS-CoV-2 was rare and not via the placenta. Most placentas had non-specific findings and a subset showed mild maternal vascular malperfusion and/or mild microscopic ascending intrauterine infection, which were not associated with maternal COVID-19 severity.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies

Ward¹,

Cornaby²,

Kato

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…All the placentas in this study underwent medical pathology review, and we found a range of histopathologic findings. However, none of the findings differed significantly with respect to SARS-CoV-2 IgG serology status, which is consistent with some studies on Covid-19 and placenta pathology [39,51].…”

Section: Discussionsupporting

confidence: 91%

Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes

Lesseur

Jessel

Ohrn

et al. 2022

Preprint

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Introduction: Maternal SARS-CoV-2 infection during pregnancy is associated with adverse pregnancy outcomes and can have effects on the placenta, even in the absence of severe disease or vertical transmission to the fetus. This study aimed to evaluate histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy. Methods: We performed a study of 45 pregnant participants from the Generation C prospective cohort study at the Mount Sinai Health System in New York City. We compared histologic features and the expression of 48 immune and trophoblast genes in placentas delivered from 15 SARS-CoV-2 IgG antibody positive and 30 IgG SARS-CoV-2 antibody negative mothers. Statistical analyses were performed using Fisher exact tests, Spearman correlations and linear regression models. Results: The median gestational age at the time of SARS-CoV-2 IgG serology test was 35 weeks. Two of the IgG positive participants also had a positive RT-PCR nasal swab at delivery. 82.2% of the infants were delivered at term (≥37 weeks), and gestational age at delivery did not differ between the SARS-CoV-2 antibody positive and negative groups. No significant differences were detected between the groups in placental histopathology features. Differential expression analyses revealed decreased expression of two trophoblast genes (PSG3 and CGB3) and increased expression of three immune genes (CXCL10, TLR3 and DDX58) in placentas delivered from SARS-CoV-2 IgG positive participants. Discussion: SARS-CoV-2 infection during pregnancy is associated with gene expression changes of immune and trophoblast genes in the placenta at birth which could potentially contribute to long-term health effects in the offspring.

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“…All studies to date have shown the incidence of trans -placental viral transmission to be very rare and when there is SARS-CoV-2 infection of the placenta, no specific viral changes have been noted [ 14 ]. However, a recent small study [ 15 ] demonstrated that placentas positive for SARS-CoV-2 via RNA ISH demonstrated chronic histiocytic intervillositis, perivillous fibrin deposition, and trophoblastic necrosis.…”

Section: Introductionmentioning

confidence: 99%

The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies

et al. 2022

View full text Add to dashboard Cite

Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern

Cited by 48 publications

References 50 publications

The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies

The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies

Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes

The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies

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