Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation

Silagy, Christopher; Mant, David; Fowler, G. Herbert; Lodge, Mark

doi:10.1016/s0140-6736(94)90933-4

Cited by 417 publications

(173 citation statements)

References 10 publications

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“…These findings confirmed those of an earlier meta-analysis (N ϭ 11 studies), which found that smokers with the active patch were over 3 times more likely to be abstinent at short term (i.e., 3-10 weeks) and more than twice as likely to remain abstinent at long term (i.e., 24 -52 weeks) than smokers treated with placebo patches (Po, 1993). Silagy, Mant, Fowler, and Lodge (1994) conducted a metaanalysis on the efficacy of the four forms of NRT available at the time and included 53 trials: nicotine gum (n ϭ 42), patch (n ϭ 9), spray (n ϭ 1), and inhaler (n ϭ 1). Silagy et al (1994) found that all forms of NRT were significantly more effective than placebo or no treatment.…”

Section: Nicotine Replacement Therapy (Nrt): Purpose and Efficacymentioning

confidence: 99%

Meta-Analysis of the Efficacy of Nicotine Replacement Therapy for Smoking Cessation: Differences Between Men and Women.

Cepeda-Benito¹,

Reynoso²,

Erath³

2004

Journal of Consulting and Clinical Psychology

257

151

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Gender differences in the efficacy of nicotine replacement therapies (NRTs) were examined in a meta-analytical review of 90 effect sizes obtained from a sample of 21 double-blind, placebo-controlled randomized studies. Although NRT was more effective for men than placebo at 3-month, 6-month, and 12-month follow-ups, the benefits of NRT for women were clearly evident only at the 3-and 6-month follow-ups. Giving NRT in conjunction with high-intensity nonpharmacological support was more important for women than men. That is, NRT and low support were efficacious for women at only short-term follow-up, and men benefited from NRT at all the follow-ups regardless of the intensity of the adjunct support. The results suggest that long-term maintenance of NRT treatment gains decrease more rapidly for women than men.

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Section: Nicotine Replacement Therapy (Nrt): Purpose and Efficacymentioning

confidence: 99%

Meta-Analysis of the Efficacy of Nicotine Replacement Therapy for Smoking Cessation: Differences Between Men and Women.

Cepeda-Benito¹,

Reynoso²,

Erath³

2004

Journal of Consulting and Clinical Psychology

257

151

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“…Overall abstinence rates were comparable to those achieved in previous studies. [16][17][18] The logistic regression models for the treatment and follow-up phase are shown in Table 1. Smokers carrying the OPRM1 Asp40 variant were significantly more likely to be abstinent at the end of the treatment phase (OR ¼ 1.79, 1.05-3.06, P ¼ 0.03).…”

Section: Treatment Outcomementioning

confidence: 99%

The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial

et al. 2004

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To determine whether the functional mu-opioid receptor (OPRM1) Asn40Asp variant predicts the comparative efficacy of different forms of NRT, we conducted a clinical trial of transdermal nicotine (TN) vs nicotine nasal spray (NS) in 320 smokers of European ancestry. Smokers carrying the OPRM1 Asp40 variant (n ¼ 82) were significantly more likely than those homozygous for the Asn40 variant (n ¼ 238) to be abstinent at the end of treatment, and reported less mood disturbance and weight gain. The genotype effect on treatment outcome was most pronounced among smokers receiving TN, particularly during the 21 mg dose phase. Smokers who carry the OPRM1 Asp40 variant are likely to have a favorable response to TN and may benefit from extended therapy with the 21 mg dose.

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“…16 To simplify the analysis, only one type of NRT (patches) was evaluated as nicotine patches and gum were largely comparable both in terms of effectiveness 28 and local cost. Bupropion with counselling as an aid in smoking cessation has also been found to be effective compared with placebo.…”

Section: Varying Intensities Of Counselling With Pharmacotherapymentioning

confidence: 99%

Cost effectiveness analysis of smoking cessation interventions

Shearer

Shanahan

2006

Australian and New Zealand Journal of Public Health

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Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation

Cited by 417 publications

References 10 publications

Meta-Analysis of the Efficacy of Nicotine Replacement Therapy for Smoking Cessation: Differences Between Men and Women.

Meta-Analysis of the Efficacy of Nicotine Replacement Therapy for Smoking Cessation: Differences Between Men and Women.

The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial

Cost effectiveness analysis of smoking cessation interventions

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