Meta-Analysis on the Effects of Electric Acupuncture on Neural Functional Recovery and Related Pathways of Rats after Spinal Cord Injury

Abstract

Background. Spinal cord injury (SCI) is a type of damage to the central nervous system (CNS) caused by various factors. The secondary injury of SCI is more complicated. Studies have found that electroacupuncture can help the recovery of nerve function during spinal cord injury. Therefore, this study explored the efficacy of electroacupuncture on complications after spinal cord injury through meta-analysis. Methods. Relevant literatures published from January 2010 to March 2022 were searched with “Electric acupuncture, Spinal cord injury, Neural functional recovery, Spinal cord injury in rats, Neuronal Signaling” as search words. The risk of bias of included references was analyzed and assessed using RevMan 5.3 software and Stata software. Heterogeneity between studies was assessed using the Q -test and heterogeneity ( I 2 ). Results. There was no heterogeneity among the study groups. The comparison on the therapeutic effects of electroacupuncture and conventional therapy suggested that electroacupuncture was more effective for nerve recovery after spinal cord injury than conventional therapy. It can better improve the recovery of motor function after spinal cord injury in rats. On the other hand, SCI+EA had a good inhibitory effect on the expression of RhoA protein signal in rats and had a positive effect on the signal pathway. Discussion. The results of meta-analysis confirmed that electroacupuncture was more effective than conventional therapy in inhibiting pathways.

Electroacupuncture-Modulated MiR-106b-5p Expression Enhances Autophagy by Targeting Beclin-1 to Promote Motor Function Recovery After Spinal Cord Injury in Rats

“…The affected individual’s resulting inability to work (labor) and the costs of long-term treatment impose a heavy financial burden on their family and the wider community [ 1 ]. Despite concerted efforts focused on SCIs in global terms, no effective breakthrough has yet been made toward a cure for the neurological dysfunction caused by an SCI [ 2 , 3 ]. Thus, it is imperative to further explore the pathophysiological mechanism of and to develop effective rehabilitation strategies for SCIs [ 4 ].…”

Electroacupuncture promotes the repair of the damaged spinal cord in mice by mediating neurocan‐perineuronal net

“…Many researchers have proved that EA can not only relieve neuropathological pain after SCI, 26 promote the repair of motor function of injury, 27 but also improve intestinal peristalsis 28 and bladder dysfunction 29 caused by injury. It plays a particular role in the process of neuronal repair post‐SCI 30–32 . However, the mechanism of EA therapy to improve the repair of nerve function after SCI is complex and diverse, which still needs further study.…”

“…It plays a particular role in the process of neuronal repair post‐SCI. 30 , 31 , 32 However, the mechanism of EA therapy to improve the repair of nerve function after SCI is complex and diverse, which still needs further study. This study first clarified the regulatory effect of PNN on inhibitory interneurons in SCI tissues by RNA‐seq analysis and suggested that NCAN may be an important factor for the action of PNN through a protein–protein interaction network.…”

Retracted: Meta‐Analysis on the Effects of Electric Acupuncture on Neural Functional Recovery and Related Pathways of Rats after Spinal Cord Injury

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”