Meta-analysis reveals gut microbiome and functional pathway alterations in response to resistant starch

Chen, Ruimin; Zhang, Chengcheng; Fusheng, Xu; Yu, Leilei; Tian, Fang; Chen, Wei; Zhai, Qixiao

doi:10.1039/d3fo00845b

Cited by 10 publications

(5 citation statements)

References 67 publications

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“…Based on this, we speculate that the EVs isolated from plasma in our study may partly have come from intestinal bacteria. Among them, Bacteroidetes had a higher abundance ratio in the EBF group, while Firmicutes butyrate-producing Agatobacterium and Eubacterium rectal-derived EVs had a higher abundance ratio in the EBF group, which is consistent with previous reports of different gut microbiome profiles [ 43 , 44 ]. In their study, Heo et al [ 41 ] found that the microbiota that caused significant differences between the IBD group and the control group differed in the fecal microbiome and gut microbe-derived EVs.…”

Section: Discussionsupporting

confidence: 91%

Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance

Hu,

Hong,

et al. 2024

J Ovarian Res

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Introduction This study investigated changes in plasma microbial-derived extracellular vesicles (EVs) in patients with polycystic ovary syndrome and insulin resistance (PCOS-IR) before and after metformin treatment, and aimed to identify bacterial taxa within EVs that were biologically and statistically significant for diagnosis and treatment. Methods The case–control study was conducted at Xiamen Chang Gung Hospital, Hua Qiao University. Plasma samples were collected from five PCOS-IR patients of childbearing age before and after 3 months of metformin treatment, and the samples were sequenced. The diversity and taxonomic composition of different microbial communities were analyzed through full-length 16 S glycosomal RNA gene sequencing. Results After metformin treatment, fasting plasma glucose levels and IR degree of PCOS-IR patients were significantly improved. The 16 S analysis of plasma EVs from metformin-treated patients showed higher microbial diversity. There were significant differences in EVs derived from some environmental bacteria before and after metformin treatment. Notably, Streptococcus salivarius was more abundant in the metformin-treated group, suggesting it may be a potential probiotic. Discussion The study demonstrated changes in the microbial composition of plasma EVs before and after metformin treatment. The findings may offer new insights into the pathogenesis of PCOS-IR and provide new avenues for research.

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Section: Discussionsupporting

confidence: 91%

Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance

Hu,

Hong,

et al. 2024

J Ovarian Res

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“…In the present study, the Shannon index was significantly decreased after daily RS intake, while the Chao1 index showed no obvious change. We speculated the possible reason was that RS fermented in the colon to produce plenty of SCFAs, thus lowering the pH value in the intestinal lumen that provides more favorable conditions for the growth of beneficial bacteria and suppresses the growth of some gram-negative bacteria and pathogenic bacteria in the gut [22], leading to an unchanged Chao1 index. At the same time, some bacteria are less able to utilize RS and relatively reduced after RS intake; therefore, this relatively specialized nature of the community responding to RS may decrease the Shannon index [50].…”

Section: Discussionmentioning

confidence: 99%

“…Previous works have performed meta-analyses to explore the effects of RS supplementation on glycemic control [18], bowel function [19], inflammatory biomarkers [20], and serum cholesterol levels [21]. Recently, Chen et al revealed that a lower gut microbial α-diversity and higher relative abundance of Ruminococcus, Agathobacter, Faecalibacterium, and Bifidobacterium were observed at the endpoint after RS intake in comparison to the baseline [22]. However, the different effects of placebo and RS on human gut microbiota have not been systematically reviewed through meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

Effect of resistant starch supplementation on the diversity and composition of human gut microbiota: A systematic review and meta-analysis

Xu,

Kong,

et al. 2024

Food Science and Human Wellness

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Resistant starch (RS) has attracted much researchers' attention because of its health-beneficial effects. Gut microbiota obviously shapes human health, but the effects of RS supplementation on the changes of human gut microbiota remain unclear. This observational meta-analysis aimed to reveal the effects of RS intake on alpha diversity and composition of gut microbiota through meta-analysis. Two independent authors systematically searched articles from inception until February 2023 on four electronic databases. Twenty-four highly relevant trials were included conforming to Preferred Reporting Items for Systematic reviews and Meta-Analysis protocol, and a total of 816 individuals were included. Significant heterogeneity analyses revealed that RS intake notably decreased Shannon index (WMD: -0.11; 95% CI: -0.21, -0.01), and stimulated the composition of health promoting bacteria genera,

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“…RS appeared to impact mechanisms related to carbohydrate and lipid metabolism. Notably, different RS types were found to alter differently microbiome responses ( 57 ).…”

Section: Methodsmentioning

confidence: 99%

Harnessing the power of resistant starch: a narrative review of its health impact and processing challenges

Baptista,

Dessalles,

Illner

et al. 2024

Front. Nutr.

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Starch is a primary energy storage for plants, making it an essential component of many plant-based foods consumed today. Resistant starch (RS) refers to those starch fractions that escape digestion in the small intestine and reach the colon where they are fermented by the microflora. RS has been repeatedly reported as having benefits on health, but ensuring that its content remains in food processing may be challenging. The present work focuses on the impact RS on health and explores the different processes that may influence its presence in foods, thus potentially interfering with these effects. Clinical evidence published from 2010 to 2023 and studying the effect of RS on health parameters in adult populations, were identified, using PUBMED/Medline and Cochrane databases. The search focused as well on observational studies related to the effect of food processes on RS content. While processes such as milling, fermentation, cooking and heating seem to have a deleterious influence on RS content, other processes, such as cooling, cooking time, storage time, or water content, may positively impact its presence. Regarding the influence on health parameters, there is a body of evidence suggesting an overall significant beneficial effect of RS, especially type 1 and 2, on several health parameters such as glycemic response, insulin resistance index, bowel function or inflammatory markers. Effects are more substantiated in individuals suffering from metabolic diseases. The effects of RS may however be exerted differently depending on the type. A better understanding of the influence of food processes on RS can guide the development of dietary intake recommendations and contribute to the development of food products rich in RS.

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Meta-analysis reveals gut microbiome and functional pathway alterations in response to resistant starch

Abstract: Resistant starch (RS) has the ability to improve the structure of gut microbiota, regulate glucolipid metabolism and maintain the health of the human body, and has been extensively studied by...

Cited by 10 publications

References 67 publications

Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance

Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance

Effect of resistant starch supplementation on the diversity and composition of human gut microbiota: A systematic review and meta-analysis

Harnessing the power of resistant starch: a narrative review of its health impact and processing challenges

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